Pharmacodynamics

Question 1

Pharmacodynamics is?

Answer 1

What the drug (chemical) does to the body

Question 2

Drugs work in what 4 ways?

Answer 2

1) Replace missing chemicals
2) Stimulate particular cells
3) Slow down or inhibit cells
4) Interfere with foreign cells

Question 3

Drugs exert their effects on the body by binding to what 4 various proteins?

Answer 3

1) receptors
2) enzymes
3) ion channels
4) carrier ( transporter ) molecules

Question 4

What is a protein receptor?

Answer 4

A substance that fits precisely and can interact with it ( key and lock )

Question 5

What is affinity?

Answer 5

The interaction between the drug and the binding site

Question 6

What is specificity?

Answer 6

Combining with one particular receptor

Question 7

What is an agonist drug?

Answer 7

Mimics

Question 8

What is an antagonist drug?

Answer 8

Blocks

Question 9

What is a competitive antagonist?

Answer 9

Competes with the agonist for the binding site

Question 10

What is a non-competitive antagonist?

Answer 10

Binds to a site other than the agonist binding site

Question 11

What is an alpha receptor?

Answer 11

Associated with mainly increased contractibility of vascular smooth muscle and intestinal relaxation

Question 12

What is a beta-receptor?

Answer 12

Associated with vasodilation and relaxation of non intestinal smooth muscle and cardiac stimulation

Question 13

Beta blockers are a class of drugs which work by blocking what?

Answer 13

Beta receptors

Question 14

What effect would beta blockers have on cardiac muscle?

Answer 14

Reduces sympathetic influences on heart activity and makes the heart beat more slowly

Question 15

What do NSAIDS ( non-steroidal anti inflammatory drugs ) block?

Answer 15

The activity of an enzyme by inhibiting the enzyme COX that is responsible for the formation of some important chemical mediators

Question 16

What are Acetylcholinesterase inhibitors?

Answer 16

Used to improve or stabilise the symptoms of Alzheimer’s disease

Question 17

Pharmacodynamics can be defined as

Answer 17

How the drug exerts it’s effects on the body

Question 18

An antagonist for a receptor will block..

Answer 18

The receptor and inhibits the response of the endogenous ligand

Question 19

A compete or enzyme inhibitor will?

Answer 19

Block the active site of an enzyme

Question 20

Calcium channel blockers act as?

Answer 20

Vasodilator by blocking the intracellular calcium required for the contraction of arteriolar smooth muscle

Question 21

Calcium channel blockers will?

Answer 21

1) lower blood pressure
2) slow the heart down
3) reduces the force of contraction in cardiac smooth muscle

Question 22

Sodium channels block?

Answer 22

Sensation of pain

Question 23

Channel blocks prevents the sensation of pain by blocking nerve impulses, how?

Answer 23

Inhibiting sodium influx through sodium channels in the nerve cell membrane