Pharmacodynamics

Question 1

Pharmaco-______ is how a drug produces its effect

Answer 1

dynamics

Question 2

drugs that activate receptors are _____ while drugs that block receptors are _____
can be partial

Answer 2

agonist

antagonist

Question 3

drugs stimulate or block by ____ ______ or binding to a ____ _____

Answer 3

competitive inhibition

membrane protein

Question 4

drug dose phase #__ : drug is metabolized faster than it can bind to receptors, no effect

Answer 4

1

Question 5

drug dose phase #__ : dosage is increased, response increases

Answer 5

2

Question 6

drug dose phase #__: receptors are saturated and effects are reduced

Answer 6

3

plateau effect

Question 7

drugs that active a receptor more effectively are more ______

Answer 7

efficacious

Question 8

drugs that act at low dosages are very ____

Answer 8

potent

Question 9

_____ tolerance occurs when the number of receptors decreases

Answer 9

Pharmacodynamic

Question 10

______ tolerance occurs when enzyme synthesis is increased, specifically CYT P450, glucuronyl transferase

Answer 10

Metabolic

Question 11

_____ dependence occurs when displays withdrawal symptoms

Answer 11

Physical

Question 12

_____ dependence occurs when no physical symptoms are observed but compulsion to obtain the drug exists

Answer 12

Psychological

Question 13

when two drugs are taken together and the results are added: ____ effect
when the results are multiplied: _____ effect

Answer 13

additive

synergistic

Question 14

competition for inactivation occurs when multiple drugs are being taking and the enzyme ____ ____ is saturated
rate of inactivation is slowed, effects of drug increases

Answer 14

CYT P450

Question 15

_____ juice inactivates enzymes

Answer 15

grapefruit

Question 16

regular administration of drugs stimulates the ___ to make more enzymes, leading to faster inactivation and decreased efficacy
this is called enzyme _____
ex: alcohol

Answer 16

liver

induction

Question 17

Non-polar drugs bind to ___ ____ for blood transport

ex: warfarin

Answer 17

serum albumin