Parkinson's drugs

Question 1

movement disorders from Parkinson’s are called ______ and include tremors, rigidity

Answer 1

dyskinesias

Question 2

Parkinson’s is due to a lack of ____ in the ____ of the brain, which controls extra-pyramidal movements

Answer 2

dopamine

striatum

Question 3

Dopamine is produced by _____ ____ cells in the brain

Answer 3

substantia nigra

Question 4

Dopamine cannot be given itself because it does not cross the ____ _____ ____

Answer 4

blood brain barrier (BBB)

Question 5

The enzyme ____ ________ converts the drug L-DOPA into dopamine

Answer 5

DOPA decarboxylase

Question 6

the drug L-DOPA is always combined with _______, which inhibits the DOPA decarboxylase enzyme outside of the BBB
L-DOPA + carbidopa = ______

Answer 6

carbidopa

Sinemet

Question 7

adverse effects of L-dopa/carbidopa (Sinemet):

Answer 7

GI disturbance

on/off efficacy

Question 8

drugs that imitate the action of dopamine: _____and _____

Answer 8

Mirapex

Requip

Question 9

the drug _____ inhibits type B MAO. this prevents dopamine metabolism
AE: nausea and xerostomia

Answer 9

Selegiline

Question 10

the drug _____ promotes the release of dopamine from the striatum
used to reduce flu symptoms

Answer 10

Amantadine