NSAIDs Flashcards
NSAIDs stands for ____
and inhibits ___ ___
non-steroidal anti-inflammatory drugs
prostaglandin cyclooxygenase
positive effects of nsaids:
decrease sensitivity of painreceptors, body temp, cramps, platelet aggregation(aspirin)
negative effects of nsaids
reduce stomach mucus
renal vasoconstriction
primary use of nsaids:
reduce risk of ischemic strokes and MIs
decrease inflammation
pain fever
dysmenorrhea
adverse effects of nsaids
ulcers
renal failure
asthma attack
reduce ace inhibitors
COX 1 stimulates _____
COX 2 stimulates _____
most nsaids inhibit both
production of mucous lining
inflammatory response
oldest nsaid: \_\_\_ primary adverse effect: \_\_\_\_ children can get \_\_\_ syndrome not effective for \_\_\_\_\_ inhibits synthesis of \_\_\_\_ \_\_ buffered form: combined with base enteric coated: dissolves in small intestine
Aspirin (acetylsalicylic acid) ulcer Reyes dysmenorrhea thromboxane A2
Aspirin in low doses reduces risk of ___
MI
nsaid more effective in treating dysmenorrhea: ____
ibuprofen
long lasting nsaid
naproxen
other otc nsaid
ketoprofen
prescription nsaid
most efficacious
highest incidence of ulcers
short term after surgery
ketorolac
treats gout
indocin
cox 2 inhibitors:
on market: ___
not on market: ___ and ___
Celebrex
bextra
vioxx
cox 2 inhibitors do not provide protection against ___
mortality rate was too high
considered “Sulfadrug” – can cause rash and sun sensitivity
MI’s
drug that is analgesic and antipyretic, but NOT anti-inflammatory: ____
does NOT cause ulcer
high dose can cause hepatic necrosis
converted into ___ ____ that are detoxified by ____
acetaminophen
free radicals
glutathione
Rheumatoid arthritis drugs are called DMARD ______
disease modifying antirheumatic drugs
DMARD that is an antagonist of folic acid: ____
can treat Lupus
adverse effects: nausea, vomit,diarrhea
methotrexate
____ : DMARD steroid may be used during acute attack. causes edema
Prednisone
DMARD antibodies that bind TNF (tumor necrosis factor)
decrease ability to respond to infections
Enbrel, Humira
eye drop used for glaucoma
Latanprost
____ family used to treat migraines
similar to serotonin, act as serotonin agonists
first one on market: ____
triptan
sumatriptan
