NSAIDs

Question 1

NSAIDs stands for ____

and inhibits ___ ___

Answer 1

non-steroidal anti-inflammatory drugs

prostaglandin cyclooxygenase

Question 2

positive effects of nsaids:

Answer 2

decrease sensitivity of painreceptors, body temp, cramps, platelet aggregation(aspirin)

Question 3

negative effects of nsaids

Answer 3

reduce stomach mucus

renal vasoconstriction

Question 4

primary use of nsaids:

Answer 4

reduce risk of ischemic strokes and MIs
decrease inflammation
pain fever
dysmenorrhea

Question 5

adverse effects of nsaids

Answer 5

ulcers
renal failure
asthma attack
reduce ace inhibitors

Question 6

COX 1 stimulates _____
COX 2 stimulates _____
most nsaids inhibit both

Answer 6

production of mucous lining

inflammatory response

Question 7

oldest nsaid: \_\_\_
primary adverse effect: \_\_\_\_
children can get \_\_\_ syndrome
not effective for \_\_\_\_\_
inhibits synthesis of \_\_\_\_ \_\_
buffered form: combined with base
enteric coated: dissolves in small intestine

Answer 7

Aspirin (acetylsalicylic acid)
ulcer
Reyes
dysmenorrhea
thromboxane A2

Question 8

Aspirin in low doses reduces risk of ___

Answer 8

MI

Question 9

nsaid more effective in treating dysmenorrhea: ____

Answer 9

ibuprofen

Question 10

long lasting nsaid

Answer 10

naproxen

Question 11

other otc nsaid

Answer 11

ketoprofen

Question 12

prescription nsaid
most efficacious
highest incidence of ulcers
short term after surgery

Answer 12

ketorolac

Question 13

treats gout

Answer 13

indocin

Question 14

cox 2 inhibitors:
on market: ___
not on market: ___ and ___

Answer 14

Celebrex
bextra
vioxx

Question 15

cox 2 inhibitors do not provide protection against ___
mortality rate was too high
considered “Sulfadrug” – can cause rash and sun sensitivity

Answer 15

MI’s

Question 16

drug that is analgesic and antipyretic, but NOT anti-inflammatory: ____
does NOT cause ulcer
high dose can cause hepatic necrosis
converted into ___ ____ that are detoxified by ____

Answer 16

acetaminophen
free radicals
glutathione

Question 17

Rheumatoid arthritis drugs are called DMARD ______

Answer 17

disease modifying antirheumatic drugs

Question 18

DMARD that is an antagonist of folic acid: ____
can treat Lupus
adverse effects: nausea, vomit,diarrhea

Answer 18

methotrexate

Question 19

____ : DMARD steroid may be used during acute attack. causes edema

Answer 19

Prednisone

Question 20

DMARD antibodies that bind TNF (tumor necrosis factor)

decrease ability to respond to infections

Answer 20

Enbrel, Humira

Question 21

eye drop used for glaucoma

Answer 21

Latanprost

Question 22

____ family used to treat migraines
similar to serotonin, act as serotonin agonists
first one on market: ____

Answer 22

triptan

sumatriptan