Antidepressants

Question 1

depression is due to low levels of 3 monoamine neurotransmitters in the brain: ____ ____, and ____

Answer 1

norepinephrine, serotonin, and dopamine

Question 2

using multiple drugs at once is called ____

Answer 2

polypharmacy

Question 3

using one drug is called _____

Answer 3

monotherapy

Question 4

the two most common tricyclic antidepressants (TCA’s) are ____ and ____

Answer 4

amitriptyline

imipramine

Question 5

TCA’s prevent reuptake of ___ and ____ at afferent neurons, raising the levels of these

Answer 5

serotonin

norepinephrine

Question 6

some adverse effects of TCA’s:

Answer 6

orthostatic hypotension
dry mouth
sedation

Question 7

unlabeled use of TCA’s:

Answer 7

prophylactic treat of migraines

Question 8

earliest antidepressants on the market, no longer prescribed: ____ ______

Answer 8

MAO inhibitors

monoamine oxidase

Question 9

SSRI stands for:

Answer 9

Selective Serotonin Reuptake Inhibitor

Question 10

most commonly prescribed family of antidepressants:

Answer 10

SSRI’s

Question 11

two major advantages of SSRI’s or TCA’s

Answer 11

less adverse effects

higher TI

Question 12

SSRI’s increase ____ rates in teens

Answer 12

suicide

Question 13

SSRI’s can also treat:

Answer 13

OCD
generalized anxiety disorder
panic attacks

Question 14

first SSRI on the market: _____
AE: sexual dysfunction, nausea
long half life
inhibits CYT P450

Answer 14

Prozac

Question 15

other SSRI’s similar to Prozac, but shorter half lives and less inhibition f CYT P450

Answer 15

Paxil, Zoloft, Citalopram

Question 16

Pure S isomer of citalopram: _____
fewer side effects
(Citalopram is the racemic mixture)

Answer 16

Escitalopram

Question 17

Insomnia and anxiety from SSRI’s can be reduce by adding a ____ such as _____

Answer 17

TCA

amitriptyline

Question 18

high doses of SSRI’s can cause: ____ ____ syndrome

stopping SSRI’s abruptly may cause ____ ____ syndrome

Answer 18

excess serotonin

serotonin discontinuation

Question 19

SARI stands for:

Answer 19

Serotonin Antagonist and Reuptake Inhibitor

Question 20

the only SARI: _____
also used as sedative for insomnia
AE: very sedating

Answer 20

Trazodone (the one in the book)

Question 21

SNRI stands for:

Answer 21

Serotonin and Norepinephrine Reuptake Inhibitor

Question 22

the SNRI _____ claims less agitation than SSRIs

difficult withdrawal symptoms

Answer 22

Venlafaxine

Question 23

metabolite of the SNRI Venlafaxine: ______

Answer 23

Desvenlafaxine

Question 24

SNRI that is very potent: ______

also treats fibromyalgia and diabetic neuropathic pain

Answer 24

Duloxetine(Cymbalta)

Question 25

NDRI stands for:

Answer 25

Norepinephrine and Dopamine Reuptake Inhibitors

Question 26

the only NDRI: _____

the same drug under a different name is used for aiding smoking cessation: _____

Answer 26

bupropion

Zyban

Question 27

Bipolar patients with rapid mood changes are called: rapid ____
slow changes: slow _____
elevated moods: ____ bipolar
high anxiety: ____ bipolar

Answer 27

cyclers
cyclers
euphoric
dysphoric

Question 28

____ ____ used to be drug of choice for bipolar, not anymore due to low TI and lots of effects.
works best in ___ ____ cyclers
AE: polyuria

Answer 28

Lithium Carbonate

euphoric slow

Question 29

Anti-seizure meds used for bipolar:
1.
2.
3.

Answer 29

Valproic acid
Carbamazepine
Oxcarbamazepine

Question 30

Atypical anti-psychotic meds used for bipolar:
1.
2.
3.
4.

Answer 30

Olanzapine
Seroquel
Abilify
Risperdal

Question 31

SSRI’s can be used as appetite suppressant for weight loss
Fenfluramine combined with phentermine: ______
Pure form of fenfluramine: ______

Answer 31

fen-phen

Redux