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Pharm > Nervous system drugs > Flashcards

Nervous system drugs Flashcards

1
Q

inhibition of the electrical conduction down the axon produces _____

A

anesthesia

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2
Q

____ is a general inhalation anesthetic that is very flammable, not used in US

A

ether

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3
Q

____ is a general anesthetic that causes heart arrhythmias and liver damage, not used in US

A

Chloroform

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4
Q

_____ is fluorinated ether, non-flammable and no liver damage

A

Sevofluorane

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5
Q

______ is the neurotransmitter at the ganglia of BOTH sympathetic and parasympathetic nervous systems
bind to ______ receptors at the ganglia
binds to _____ receptors at the post-ganglionic parasympathetic neuron

A

Acetylcholine
nicotinic
muscarinic

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6
Q

drugs that activate post-ganglionic parasympathetic muscarinic receptors are called ______ agonists/antagonists

A

cholinergic

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7
Q

acetylcholine is terminated by _______

A

acetylcholinesterase

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8
Q

______ is the neurotransmitter at the post-ganglionic sympathetic neuron

A

norepinephrine

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9
Q

Norepinephrine is terminated by resorption into the _____ neuron, then eventually inactivated by _______ ____ and ____ _____ _____

A

afferent
monoamine oxidase (MAO)
catechol orthomethyl transferase (COMT)

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10
Q

_____ is a sympathetic neurotransmitter that is released by the _____ _____
inactivated by _______ _____

A

Epinephrine
adrenal medulla
monoamine oxidase

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11
Q

Norepinephrine and epinephrine bind _____ receptors

A

adrenergic

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12
Q 
effects of parasympathetic stimulation at Cholinergic receptors:
pupil \_\_\_\_
heart rate \_\_\_\_
broncho-\_\_\_\_\_
bladder \_\_\_\_\_
salivation
erection
A

constricts
decreases
constriction
voiding

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13
Q 
effects of sympathetic stimulation at Adrenergic receptors:
pupil \_\_\_\_\_
heart rate \_\_\_\_\_
vaso-\_\_\_\_\_
broncho-\_\_\_\_\_
skin vaso-\_\_\_\_\_
GI vaso-\_\_\_\_\_
ejaculation
A 
dilates
increases
dilation
dilation
constriction
constriction
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14
Q

______ acts on all four types of adrenergic receptors

______ acts on all but B2

A

epinephrine

norepinephrine

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15
Q

_____ is a cholinergic agonist that stimulates contraction of detrusor muscle
stimulates _____ post-op or post-partum

A

Bethanecol

urination

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16
Q

_____ inhibitors increase ACh by blocking its inactivation
found in insecticides and nerve gas
can cause muscular and respiratory paralysis

A

cholinesterase

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17
Q

_____ is a cholinergic antagonist used to increase heart rate, and an antidote for poisoning

A

Atropine

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18
Q

the plant ____ _____ is a natural source of Atropine

A

bella donna

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19
Q

_____ _____ is an anticholinergic antagonist given by inhaler for COPD
used in combo with Albuterol to make Combivent

A

Atrovent

20
Q

_____ is an antispasmodic used to treat nocturia, incontinence
available as patch

A

oxybutynin

21
Q

newer antispasmodic to compete with oxybutynin: _______

A

Detrol

22
Q

Norepinephrine and epinephrine have similar ________ structure
rapidly metabolized in ____ and ___ ____
undergo the ____ ____ effect

A

catecholamine
liver
GI tract
first pass

23
Q

epinephrine given by inhalation

used for anaphylactic shock

A

Primatene mist

24
Q

_____ is used as a nasal decongestant
cause vaso-_____
now behind the counter because it can be converted into _____

A

Pseudoephedrine
constriction
methamphetamine

25
Q

many formulas are replacing pseudoephedrine with ______

A

phenylephrine

26
Q

_____ is the isomer of pseudoephedrine, found in Chinese herb Mahuang

A

Ephedrine

27
Q

____ and _____ are synthetic versions of epinephrine, now common street drugs
injected as crystal or smoked in free base form

A

Amphetamine

methylamphetamine

28
Q

when meth users hallucinate about bugs crawling on their skin: _____

A

formication

29
Q

___ and ____ are popular rave drugs, ecstasy

Schedule 1

A

MDA

MDMA

30
Q

____ is a shrub grown in Yemen that contains ______

A

Khat

Cathinone

31
Q

____ ____ are synthetic versions of cathinone

A

bath salts

32
Q

____ is used to treat ADHD

Schedule 2

A

Ritalin

33
Q

pure enantiomer of Ritalin: _____

A

Focalin

34
Q

_____ is used for ADHD and is commonly abused

Schedule 2

A

Adderall

35
Q

_____ was officially approved for treating narcolepsy, shift work sleep disorder , off label for ADHD

A

Modafinil

36
Q

B1: ___
B2: ___
A1:___

A

heart
lungs
skin, etc

37
Q

_____ is a B2 agonist that prevents premature parturition

A

Terbutaline

38
Q

_____ and ____ are A1 blockers that cause peripheral vaso-____ and are used for BPH which stands for: ____ ____ ____
alternative to TURP which stands for: ____ ____ ____ ____

A 
Cardura
Flomax
dilation
benign prostate hypertrophy
trans-urethral resection of the prostate
39
Q

_____ was one of the first anti-hypertensive drugs, acts on CNS
frequently causes depression

A

Reserpine

40
Q

_____ is used for treating muscle spasms

acts on CNS

A

Cyclobenzaprine

41
Q

ACh stimulates __-polarization, which stimulates the release of ___ and causes contraction

A

de

Ca+2

42
Q

neuromuscular blocker _____ binds to ACh receptors and prevents repolarization
given IV for surgery
AE: sore muscles

A

Succinylcholine

43
Q

_____ is a neuromuscular blocker that is used on the arrow tips by South American natives
not safe for surgery

A

Tubocurarine

44
Q

______ can be found in patches for smoking cessation called: _____, _____, _____

A

Nicoderm
Habitrol
Prostep

45
Q

____ is a partial nictone agonist that has a bad rep from lawsuits about suicide

A

Chantix

46
Q

____ is a seed/leaf chewed in Southeast Asia
stimulates nicotine receptors
dark red saliva

A

Betel

Pharm (17 decks)

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