Pharmacodynamics Flashcards
name some physical changes that drugs can cause
changes in surface tension
lubrification
adsorption
name some chemical changes that drugs can cause
neutralization
pH change
body fluid changes
affinity
force of attraction between receptor and drug
force of attraction between receptor and drug
affinity
selectivity
degree to which a drug acts on a given target relative to other sites
degree to which a drug acts on a given target relative to other sites
selectivity
agonism
when a drug has affinity for a receptor, and binding HAS a pharmacological response
antagonism
when a drug has affinity for a receptor and binding HAS NO pharmacological response
what is the dose response curve
the relationship between the size of a dose and the intensity of the response produced
what 3 things does the dose-response curve determine
min drug to be used
max response possible
how much to inc the dosage by to produce the desired inc in response
efficacy
the largest effect a drug can produce
potency
the amount of drug that must be given to elicit an effect
the largest effect a drug can produce
efficacy
the amount of drug that must be given to elicit an effect
potency
when is therapeutic drug monitoring important
when drugs have a small margin of safety
