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Pharmacology > ANS pt 2 - slides 18+ > Flashcards

ANS pt 2 - slides 18+ Flashcards

1
Q

what explains some of the adverse effects associated with non-selective beta blockers

A

unwanted blockade of beta 2 receptors instead of the targeted beta 1

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2
Q

what are two mixed-acting sympathomimetics that can be used to treat nasal congestion

A

ephedrine
pseudoephedrine

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3
Q

name an alpha 2 antagonist

A

yohimbine

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4
Q

what are beta 1 antagonists used to treat

A

hypertension
angina
arrhythmias

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5
Q

what is the action of alpha 1 antagonists

A

reduces vasoconstriction and peripheral resistance

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6
Q

name 4 uses of alpha 1 agonists

A

control superficial bleeding
reduces congestion
mydirasis
hypotensive emergencies

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7
Q

how do you treat toxicity of amphetamine

A

acidification of urine

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8
Q

what is a use of clonidine (alpha 2 agonist)

A

antihypertensive

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9
Q

what are the 3 kinds of indirect acting sympathomimetics

A

displacement drugs

inhibit reuptake of NE from synapse

Inhibit NE breakdown in neurons

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10
Q

adverse effects of beta 1 blockade

A

bradycardia
HF
hypotension

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11
Q

what are some adverse effects of amphetamine

A

insomina
irritability
psychosis
anorexia
tacchycardia
dependance
tolerance

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12
Q

name 7 uses for beta antagonists

A

angina
hypertension
HF
post MI
arrhythmias
stage fright/anxiety
migrane prophylaxis

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13
Q

what is the mechanism of adrenergic antagonists

A

generally reversible blockade of adrenergic receptors

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14
Q

what is an adverse effect of alpha 1 agonists

A

excessive inc in BP

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15
Q

what is a reversible non-selective alpha antagonist

A

phentolamine

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16
Q

what receptors can dopamine bind to

A

Dopamine receptors
alpha 1
beta 1
beta 2

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17
Q

what type of drug is propranolol

A

non-selective beta antagonist

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18
Q

what is the use of mirabegron

A

reduce urinary urgency/incontinence

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19
Q

what are 3 uses of amphetamine

A

stimulates CNS
treat ADD
decrease appetite

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20
Q

what kind of drug is yohimbine

A

alpha 2 antagonist

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21
Q

what receptors can adrenaline bind to

A

alpha and beta adrenergic receptors

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22
Q

what’s a example of a beta 1 agonist

A

dobutamine

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23
Q

name an alpha 1 agonist

A

phenylephrine

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24
Q

what is a use for dobutamine (beta 1 agonist)

A

treat acute heart failure

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25
Q

what is the effect of salbutamol

A

dilates bronchi

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26
Q

how do displacement drugs work

A

stimulate release of stored NA from vesicles into the synapse

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27
Q

what is the use of alpha 1 antagonists

A

treats hypertension

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28
Q

adverse effects of beta 2 blockage

A

bronchoconstriction
inhibition of hepatic glycogenolysis

inhibition of hypoglycemia symptoms

inhibiton of lipolysis

inhibition of peripheral vasodilation of BVs

29
Q

what receptors can noradrenaline bind to

A

alpha 1,2
beta 1

30
Q

name 3 alpha 1 antagonists

A

prazosin
terazosin
doxazosin

31
Q

what is the name for the NE-secreting tumour

A

pheochromocytoma

32
Q

what is isoproterenol

A

non selective adrenergic agonist

33
Q

what is the effect of dobutamine

A

inc HR
inc force of contraction

34
Q

what is a example of a alpha 2 agonist

35
Q

what are 3 adverse effects of salbutamol

A

palpitations
termor
hyperglycemia

36
Q

name 2 uses of yohimbine

A

erectile dysfunction
lipolytic agent (low evidence)

37
Q

what kind of drug is phentolamine

A

reversible non-selective alpha antagonist

38
Q

what is the non selective adrenergic agonist and what receptors does it work on

A

isoproterenol
beta 1 and beta 2

39
Q

name a non-selective beta antagonist

A

propranolol

40
Q

what are the uses of non-selective alpha antagonists

A

treating NE secreting tumour

41
Q

3 things should you be aware of before administering epi

A

arrhythmias
hypertension
diabetes

42
Q

what two drugs inhibit reuptake of NE from synapse

A

cocaine
tricyclic antidepressants

43
Q

name 4 uses for epi

A

treat anaphylactic shock
cardiac arrest
control bleeding

limits diffusion of medication by local vasoconstriction

44
Q

prazosin
terazosin
doxazosin are what kind of drugs

A

alpha 1 antagonists

45
Q

what kind of drug is phenylephrine

A

alpha 1 agonist (adrenergic)

46
Q

what type of drug is mirabegron

A

beta 3 agonist

47
Q

what type of drug is salbutamol

A

beta 2 agonist

48
Q

what is a example of a beta 3 agonist

A

mirabegron

49
Q

what is an irreversible non-selective alpha antagonist

A

phenoxybenzamine

50
Q

what is the use of salbutamol

A

relieves asthma caused by bronchospasm

51
Q

what is the action of yohimbine

A

can inc perfusion of certain tissues

52
Q

what is an example of a beta 2 agonist

A

salbutamol

53
Q

what is dobutamine

A

beta 1 agonist

54
Q

what is the effect of alpha 2 agonists

A

less NA release - less sympathetic effects

55
Q

name an adverse effect of alpha 1 antagonists

A

orthostatic hypotension
+reflex inc in HR

56
Q

what drugs inhibits NE breakdown in neurons

57
Q

what kind of drug is phenoxybenzamine

A

an irreversible non-selective alpha antagonist

58
Q

what does phenylephrine do (a1 agonist)

A

vasoconstriction - inc BP
other a1 effects

59
Q

what are 2 adverse effects of beta 1 agonists

A

arrhythmias
tachycardia

60
Q

what is a pheochromocytoma

A

NE-secreting tumour

61
Q

how does clonidine work

A

presynaptic negative feedback that results in decreased NA release

62
Q

what are some adverse effects of clonidine
(and other alpha 2 agonists)

A

hypotension
xerostomia
sedation

63
Q

what is the effect of miragbegron

A

relaxation of detrusor muscle

64
Q

what are 3 beta 1 antagonists

A

metoprolol
atenolol
bisoprolol

65
Q

what are some adverse effects of blockage of all 3 beta receptors

A

sedation
lethargy
erectile dysfunction
nightmaress

66
Q

what is clonidine

A

alpha 2 agonist

67
Q

what are the 3 actions of beta 1 antagonists

A

dec HR and contractility
dec renin secretion
dec activation of renin-angiotensin-aldosterone system

68
Q

what are some adverse effects of yohimbine

A

tachycardia
hypertension
hypoglycemia

Pharmacology (12 decks)

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