Chemo pt 1 Flashcards
what are the two sulfonamides we learned about
sulfamethoxazole
sulfasalazine
what are the three diuretics that are sulfonamides
hydrochlorothiazide
furosemide
adcetazolamide
Describe gram negative bacteria
less peptidoglycan layer
third outer membrane composed of phospholipids
name some drugs associated with SJS
sulfonamides
anti-seizure
allopurinol (gout)
NSAIDs (oxicams)
what is the name of the insulin secretion promoting sulfonylureas drug
glyburide
What are the adverse effects of folate antagonists
hypersensitivity
crystalluria
pregnancy (low folate levels)
what is an adverse effect of trimethoprim
hyperkalemia
what is folate necessary for
synthesis of nucelotides and some amino acids
how does trimethoprim work
inhibits downstream reaction where (DHF) folate is turned into activated folate (THF)
what is the anti-inflammatory sulfonamide
celecoxib (COX-2 inhibitor)
Describe gram positive bacteria
thick cell wall
thick peptidoglycan layer
how do sulfonamides work
they resemble PABA and compete with the bacteria to make folate
what sulfonamide is not well absorbed PO
sulfasalazine
what is it called when you mix trimethoprims and sulfonamides
co-trimoxazole
what are folate antagonists used to treat
UTIs
Skin absecesses
what are the 2 types of folate antagonists
sulfonamides
trimethoprim
most bacteria synthesize folate from what precursor
PABA
