PHARMA WEEK 1 Flashcards
is the study of drugs and its origin, chemical structure, preparation, administration, action, metabolism and excretion.
Pharmacology
art of preparing, compounding, and dispensing drugs. It also refers to the place where drugs are prepared and dispensed
PHARMACY
a person licensed to prepare and dispense drugs to make up prescriptions.
PHARMACIST
PHARMACOLOGY STUDY
Clinical pharmacology
Toxicology
Pharmacy
a person licensed to prepare and dispense drugs and make up prescriptions
Pharmacist
is a specialist who often guides the physician in prescribing drugs.
CLINICAL PHARMACIST
TOPICAL MEDICATIONS
Transdermal Patch
Can be used for self administration
Disadvantage: causes discomfort
RECTUS FEMORIS
● Rapid absorption for adults
● Cannot administer more than 1 ml.
Deltoid
CONTRAINDICATED:
● children under 3 y/o
● Increased risk of striking the SCIATIC NERVE
Dorsogluteal
Site of choice for 1 y/o and younger
● Infants with fully developed gluteal
muscles
Ventrogluteal
4 primary reason for giving drugs parenterally:
- Unable to take oral drugs
- Need a drug that acts rapidly
- Need a constant blood level of the drug
- Need drugs such as Insulin, which are not made in an oral form.
Most common route
ORAL MEDICATION
OBSERVE THE TEN RIGHTS
- Right Client
- Right Medication
- Right Dose
- Right Time
- Right Route
- Right Client Education
- Right Documentation
- Right to Refuse
- Right Assessment
- Right Evaluation
one several drugs mixed with a firm base such as gelatin and shaped for insertion into the body; the base dissolves gradually at body temperature, releasing the drug.
Suppository
a semipermeable membrane shaped in the form of a disc patch that contains a drug to be absorbe through the skin over a long period of tin
Transdermal patch
a medication mixed with alcohol, oil, or soapy emollient and applied to the skin.
Liniment
a non-greasy, semi solid preparation used on the skin.
Cream
a preparation like an ointment, but thicker and stiff, that penetrates the skin less than an ointment
Paste
a semisolid preparation of one or more drugs used for application to the skin less than an ointment.
Ointment
a medication in a liquid suspension applied to the skin.
Lotion
a clear or translucent semi solid that liquefies when applied to the skin.
Gel or jelly
a finely ground drug or drugs; some are used internally, other externally.
Powder
one or more drugs mixed with a cohesive material, in oval, round, or flattened shapes.
Pill
a flat, round, or oval preparation that dissolves and releases a drug when held in the mouth.
Lozenge (troche)
a powdered drug compressed into a hard small disc
Tablet
a gelatinous container to hold a drug in powder, liquid, or oil form.
Capsule
a solid form, shaped like a capsule, coated and easily swallowed.
Caplet
an aqueous solution of sugar often used to disguise unpleasant tasting drugs
Syrup
a concentrated form of a drug made from vegetables or animals.
Extract
a sweetened and aromatic solution of alcohol used as a vehicle for medicinal agents.
Elixir
one or more drugs finely divided in a liquid such as water.
Aqueous suspension
one or more drugs dissolved in water.
Aqueous solution
a liquid, powder, or foam deposited in a thin layer on the skin by air pressure.
Aerosol spray of foam
is a compilation of the package insert information from drugs used in this country, along with some drug advertising.
Physician’s Drug Reference (PDR)
has drug monographs organized alphabetically and includes nursing implications and patient teaching points.
Nursing Drug Guide (NDG)
contains all of the chemical and study information that led to the drug’s approval.
Package inserts
identifies the brand and generic names for the drug, the drug dosage, the expiration date, and special drug warnings.
Drug Labels
Individual drugs that represent groups of drugs are called
Prototype drugs
responsible for safeguarding public health & safety Protecting the public health through the enforcement of its standards.
FDA
drugs with abuse potential
Controlled Substances
are drugs no longer protected by patent and can be produced by companies other than the one that developed it.
Generic drugs
drugs are available without a prescription and are deemed safe when used as directed.
Over-the-counter (OTC)
are drugs that have been discovered but are not financially viable and therefore have not been “adopted” by any drug company.
Orphan drugs
> drugs approved for marketing by FDA > continues evaluation
PHASE 4
> chemicals cleared for large-scale clinical studies > some chemicals may not advance further in the next phase due to the following criteria:
PHASE III
> chemicals cleared for limited clinical studies
some may not further proceed with the evaluation due to the following criteria
less effective than expected
are too toxic
produce unacceptable side effects
have a low benefit-to-risk ratio
are not as effective as available drugs
test potential drugs on patients who have the disease the drugs are designed to treat.
Phase II
> chemicals cleared for human testing, there are significant therapeutic benefits.
testing done on healthy male subjects
companies begin developing a brand name >test potential drugs on healthy human subjects.
Phase I
= testing done on laboratory performed in animals
= tests efficacy and toxicity, at different doses, it predicts whether the drug will cause harm to humans.
PRECLINICAL TRIAL
series of scientific tests to evaluate the actual therapeutic and toxic effects of chemicals
DRUG EVALUATION
the branch of science concerned with the nature, effects, and detection of poisons.the measurement and analysis of potential toxins, intoxicating or banned substances, and prescription medications present in a person’s body
Toxicology
the practice of monitoring the effects of medical drugs after they have been licensed for use especially in order to identify and evaluate previously unreported adverse reactions.
Pharmacovigilance
the study of the therapeutic uses and effects of drugs. Beneficial and adverse effects of drugs.
Pharmacotherapeutics
the branch of knowledge concerned with medicinal drugs obtained from plants or other natural resources
Pharmacognosy
The study of drug movement throughout the body. How the body deals with medications. Actions and side effects of medications in patients.
Pharmacokinetics
Refers to how a medicine changes the body the branch of pharmacology concerned with mechanisms of drug action and the relationships between drug concentration and responses in the body.
Pharmacodynamics
occurs when two different drugs increase the action of one or another drug.
SYNERGISTIC EFFECT
when two of the same types of drug increase the action of each other
ADDITIVE EFFECT
increasing the effect of drug
POTENTIATING EFFECT
decreasing the effect of drug
INHIBITING EFFECT
occurs when the administration of one drug before, at the same time as, or after another drug alters the effect of one or both drugs.
• may be beneficial or harmful.
DRUG INTERACTION
exists in person with unusually low physiologic response to a drug
Drug Tolerance
- immunologic reaction to drug or hypersensitivity
- should have skin test for IV drugs
- should ask patient for allergy in oral drugs
- if the pt. have many food allergy then ask the doc.
Drug Allergy
deleterious effects of a drug resulting from over dosage, ingestion of external use drug, and accumulation on the blood stream
Drug Toxicity
also referred as the secondary effect (unintended effect)
Side Effect
- Also referred as the desired effect (primary effect intended)
Therapeutic Effect
written direction for the preparation and administration of drugs.
PRESCRIPTION
is a substance administered for the diagnosis, cure, treatment, or relief of symptoms or for prevention of disease.
MEDICATION
Name that describes the atomic or chemical structure.
Chemical Name
Name given by the manufacturer of the drug
Brand Name or Trade Name
Name approved by the Medical or Pharmaceutical Associations in the original country of manufacture and is adopted by all countries
Generic or Nonproprietary Name
- Are chemicals that alter physiochemical processes in body cell.
- They can stimulate or inhibit normal cellular functions.
- Used interchangeably with medicines.
Drug Definition
Drug
Father of American Pharmacology
John Jacob Abel
(first isolated morphine from opium, injected himself and three other friends with huge doses (100mg)
Fredrich Serturner
study their effects in animals
Pharmacologists
isolates specific substances from complex mixtures
Early 1800s
- Chemists
First recorded reference to the word pharmacology.
Pharmacologia sen Manuductio and Materia Medicum
Archives of remedies on a document known as
Erb’s Papyrus
a 40- volume compendium of plant remedies dating to 2700 B.C.
Pen Tsao (great herbal)
Earliest surviving “prescriptions” on clay tablets in 3000 B.C.
Babylonians