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Pharma > Pharma Thyroid > Flashcards

Pharma Thyroid Flashcards

0
Q

Synthetic thyroid preparations

A

Levothyroxine
Liothyronine
Liotrix

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1
Q

Thyroid deprivation in early life

A

Cretinism

Dwarfism

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2
Q

Thyroid hormone clinical use

A

Obesity
Abnormal vaginal bleeding
Depression

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3
Q

Preparation of choice fir thyroid replacement

A

Synthetic levothyroxine

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4
Q

Liothyronine ae

A

Cardiotoxicity

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5
Q

Dessicated thyroid disadvantages

A

Protein antigenicity

Product instability

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6
Q

Thioamides

A

Ptu
Methimazole
Carbimazole

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7
Q

Methimazole

A

Ten times more potent than ptu

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8
Q

Metimazole prodrug

A

Carbimazole

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9
Q

Thiamazole

A

Metimazole na completely absorbed, once a day dosing

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10
Q

Congenital aplasia crutis??

A

Side effect of methimazole

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11
Q

Methimazole side effect ?

A

Maculopapular pruritic rash

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12
Q

Most dangerous complication of methimazole

A

Agranulocytosis

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13
Q

Anion inhibitors MOA

A

block uptake of iodide

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14
Q

Potassium perchlorate clinical use

A

Iodide induced hyperthyroidism

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15
Q

Jod basedow phenomenon

A

When iodides can induce hyperthyroidism (unpredictable effect)

16
Q

Iodide main moa

A

Inhibit hormone release

17
Q

What to use for radiation emergencies

A

Iodides

18
Q

Iodide toxicity

A

Acneiform rash

19
Q

Beta blockers without isa

A

Propanolol
Metoprolol
Atenolol

20
Q

Diagnostic of hashimotos thyroiditis

A

Antithyroid antibodies

21
Q

Levothyroxine dose

A

1.7 mcg per kg per day, OD

22
Q

Thyrotoxicity

A

In elderly.. Atrial fibrillation and accelerated osteoporosis

23
Q

Large doses of iodine inhibit iodide organification

A

Wolff Chaikoff block

Pharma (20 decks)

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