Pharma Thyroid Flashcards
Synthetic thyroid preparations
Levothyroxine
Liothyronine
Liotrix
Thyroid deprivation in early life
Cretinism
Dwarfism
Thyroid hormone clinical use
Obesity
Abnormal vaginal bleeding
Depression
Preparation of choice fir thyroid replacement
Synthetic levothyroxine
Liothyronine ae
Cardiotoxicity
Dessicated thyroid disadvantages
Protein antigenicity
Product instability
Thioamides
Ptu
Methimazole
Carbimazole
Methimazole
Ten times more potent than ptu
Metimazole prodrug
Carbimazole
Thiamazole
Metimazole na completely absorbed, once a day dosing
Congenital aplasia crutis??
Side effect of methimazole
Methimazole side effect ?
Maculopapular pruritic rash
Most dangerous complication of methimazole
Agranulocytosis
Anion inhibitors MOA
block uptake of iodide
Potassium perchlorate clinical use
Iodide induced hyperthyroidism
Jod basedow phenomenon
When iodides can induce hyperthyroidism (unpredictable effect)
Iodide main moa
Inhibit hormone release
What to use for radiation emergencies
Iodides
Iodide toxicity
Acneiform rash
Beta blockers without isa
Propanolol
Metoprolol
Atenolol
Diagnostic of hashimotos thyroiditis
Antithyroid antibodies
Levothyroxine dose
1.7 mcg per kg per day, OD
Thyrotoxicity
In elderly.. Atrial fibrillation and accelerated osteoporosis
Large doses of iodine inhibit iodide organification
Wolff Chaikoff block