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Pharma > Anti Folate > Flashcards

Anti Folate Flashcards

0
Q

Sulfonamides moa

A

Inbit dihydropteroate SYNTHASE

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1
Q

Structural analogs of paba

A

Sulfonamides

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2
Q

Oral, absorbable short acting sulfonamide

A

Sulfisoxazole

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3
Q

Sulfisoxazole use

A

used almost exclusively for UTI

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4
Q

Oral, absorbable intermediate acting sulfonamide

A

Sulfadiazine

Sulfamethoxazole

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5
Q

Oral, absorbable long acting sulfonamide

A

Sulfadoxine

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6
Q

Oral, non absorbable sulfonamide

A

Sulfasalazine

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7
Q

Topical sulfonamides

A

Sodium sulfacetamide
Malenide acetate
Silver sulfadiazine

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8
Q

Sulfadiazine + pyrimethamine + folinic acid

A

Toxoplasmosis

Leishmaniasis

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9
Q

Sulfadoxine + pyrimethamine

A

Malaria tx

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10
Q

Trimethoprim + sulfamethoxazole

A

DOC for pneumocystis jiroveci pneumonia
Toxoplasmosis
Nocardiosis

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11
Q

Sulfasalazine use

A

Not absorbed, acts locally, so use in GI lesions like ulcerative colitis and enteritis

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12
Q

Topical tx for bacterial conjunctivitis and trachoma

A

Sodium sulfacetamide

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13
Q

Topical sulfonamide that inhibits carbonic anhydrase causing met acidosis

A

Mafenide acetate

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14
Q

Topical sulfonamide for burn wounds

A

Silver sulfadiazine

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15
Q

Causes stevens johnson syndrome

A

Sulfonamides

16
Q

Other adrs of sulfonamides

A

Crystalluria, hematuria, obstruction
Hematopoiesis influence
Kernicterus
Bleeding with warfarin interaction

17
Q

Combination ratio of trimethoprim and sulfonamides

A

1:5

less tri needed because it is more lipid soluble

18
Q

Sequential synergistic blockade exhibited by

A

Trimethoprims when it follows sulfonamides

19
Q

Synthetic fluorinated analogs of nalidixic acid

A

Fluoroquinolones

20
Q

Fluoroquinolones MOA

A

Inhibits bacterial topoisomerase II (dna gyrase) and topoisomerase IV (separation of replicated dna into daughter cells)

21
Q

First gen fluoroquinolone

A

Nalidixic acid

22
Q

Second gen fluoroquinolone

A

Norfloxacin

23
Q

Third gen fluoroquinolone

A

Ciprofloxacin
Levofloxacin
Ofloxacin

24
Q

Fourth gen fluoroquinolone

A

Moxifloxacin

25
Q

Fluoroquinolone with 3 hr half life

A

Norfloxacin

Ciprofloxacin

26
Q

Fluoroquinolone with 10 hr half life

A

Perfloxacin

Fleroxacin

27
Q

Fluoroquinolone with long half life

A

Sparfloxacin
Levofloxacin
Moxifloxacin
Trovafloxacin

28
Q

L isomer of ofloxacin

A

Levofloxacin

29
Q

Fluoroquinolone pulled out bc lots if cardiovascular adrs

A

Gatifloxacin

30
Q

DOC px and tx anthrax

A

Ciprofloxacin

31
Q

Fluoroquinolone for gonococcal and chlamydia

A

Ciprofloxacin and levofloxacin

32
Q

Fluoroquinolone for drug resistant tb and atypical mycobacterium

A

Cipro
Levo
Moxi

33
Q

Respiratory quinolones

A

Levo
Gati
Gemi
Moxi

34
Q

Gatifloxacin adrs

A

Qt prolongation, torsades de point
Hyper and hypogly
Inhibit collagen synthesis, tendinitis

35
Q

Protozoan infections with metronidazole as DOC

A

Entamoeba histolytica
Giardia lambia
Trichomonas vaginalis

36
Q

Anaerobic infections with metronidazole as DOC

A

Bacteroides fragilis
Clostridium difficile
Giardia vaginalis

37
Q

With the ff adrs - metallic taste, brown black urine, disulfiram like

A

Metronidazole

38
Q

Antibiotics for h pylori ulcers

A

Amoxicillin
Clarithromycin
Tetracycline
Metronidazole

Pharma (20 decks)

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