Anti Folate

Question 0

Sulfonamides moa

Answer 0

Inbit dihydropteroate SYNTHASE

Question 1

Structural analogs of paba

Answer 1

Sulfonamides

Question 2

Oral, absorbable short acting sulfonamide

Answer 2

Sulfisoxazole

Question 3

Sulfisoxazole use

Answer 3

used almost exclusively for UTI

Question 4

Oral, absorbable intermediate acting sulfonamide

Answer 4

Sulfadiazine

Sulfamethoxazole

Question 5

Oral, absorbable long acting sulfonamide

Answer 5

Sulfadoxine

Question 6

Oral, non absorbable sulfonamide

Answer 6

Sulfasalazine

Question 7

Topical sulfonamides

Answer 7

Sodium sulfacetamide
Malenide acetate
Silver sulfadiazine

Question 8

Sulfadiazine + pyrimethamine + folinic acid

Answer 8

Toxoplasmosis

Leishmaniasis

Question 9

Sulfadoxine + pyrimethamine

Answer 9

Malaria tx

Question 10

Trimethoprim + sulfamethoxazole

Answer 10

DOC for pneumocystis jiroveci pneumonia
Toxoplasmosis
Nocardiosis

Question 11

Sulfasalazine use

Answer 11

Not absorbed, acts locally, so use in GI lesions like ulcerative colitis and enteritis

Question 12

Topical tx for bacterial conjunctivitis and trachoma

Answer 12

Sodium sulfacetamide

Question 13

Topical sulfonamide that inhibits carbonic anhydrase causing met acidosis

Answer 13

Mafenide acetate

Question 14

Topical sulfonamide for burn wounds

Answer 14

Silver sulfadiazine

Question 15

Causes stevens johnson syndrome

Answer 15

Sulfonamides

Question 16

Other adrs of sulfonamides

Answer 16

Crystalluria, hematuria, obstruction
Hematopoiesis influence
Kernicterus
Bleeding with warfarin interaction

Question 17

Combination ratio of trimethoprim and sulfonamides

Answer 17

1:5

less tri needed because it is more lipid soluble

Question 18

Sequential synergistic blockade exhibited by

Answer 18

Trimethoprims when it follows sulfonamides

Question 19

Synthetic fluorinated analogs of nalidixic acid

Answer 19

Fluoroquinolones

Question 20

Fluoroquinolones MOA

Answer 20

Inhibits bacterial topoisomerase II (dna gyrase) and topoisomerase IV (separation of replicated dna into daughter cells)

Question 21

First gen fluoroquinolone

Answer 21

Nalidixic acid

Question 22

Second gen fluoroquinolone

Answer 22

Norfloxacin

Question 23

Third gen fluoroquinolone

Answer 23

Ciprofloxacin
Levofloxacin
Ofloxacin

Question 24

Fourth gen fluoroquinolone

Answer 24

Moxifloxacin

Question 25

Fluoroquinolone with 3 hr half life

Answer 25

Norfloxacin | Ciprofloxacin

Question 26

Fluoroquinolone with 10 hr half life

Answer 26

Perfloxacin | Fleroxacin

Question 27

Fluoroquinolone with long half life

Answer 27

Sparfloxacin Levofloxacin Moxifloxacin Trovafloxacin

Question 28

L isomer of ofloxacin

Answer 28

Levofloxacin

Question 29

Fluoroquinolone pulled out bc lots if cardiovascular adrs

Answer 29

Gatifloxacin

Question 30

DOC px and tx anthrax

Answer 30

Ciprofloxacin

Question 31

Fluoroquinolone for gonococcal and chlamydia

Answer 31

Ciprofloxacin and levofloxacin

Question 32

Fluoroquinolone for drug resistant tb and atypical mycobacterium

Answer 32

Cipro Levo Moxi

Question 33

Respiratory quinolones

Answer 33

Levo Gati Gemi Moxi

Question 34

Gatifloxacin adrs

Answer 34

Qt prolongation, torsades de point Hyper and hypogly Inhibit collagen synthesis, tendinitis

Question 35

Protozoan infections with metronidazole as DOC

Answer 35

Entamoeba histolytica Giardia lambia Trichomonas vaginalis

Question 36

Anaerobic infections with metronidazole as DOC

Answer 36

Bacteroides fragilis Clostridium difficile Giardia vaginalis

Question 37

With the ff adrs - metallic taste, brown black urine, disulfiram like

Answer 37

Metronidazole

Question 38

Antibiotics for h pylori ulcers

Answer 38

Amoxicillin Clarithromycin Tetracycline Metronidazole