PHARMA endocrine Drugs

Question 0

Complex of rhIGF 1 and rhIGFBP 3

Answer 0

Mecasermin

Question 1

Growth hormone side effect

Answer 1

Pseudotumor cerebri (intracranial hpn)
Scoliosis in children
Hyperglycemia

Question 2

Most important side effect of Mecasermin

Answer 2

Hypoglycemia

Question 3

Tx for GH resistant cases

Answer 3

Mecasermin

Question 4

Novel GH receptor antagonist, for small gh-secreting adenomas

Answer 4

Pegvisomant (withpolyethyleneglycol)

Question 5

Somatostatin analog

Answer 5

Octreotide

Question 6

Advantage of octreotide vs somatostatin

Answer 6

Octreotide lasts 30x longer

Question 7

Octreotide clinical use

Answer 7

For hormone secreting tumors

Question 8

Diagnostic method to localize neuroendocrine tumors ha ing sst receptor

Answer 8

Somatostatin receptor scintigraphy

Question 9

Other use of octreotide

Answer 9

Aute esophageal varices

Question 10

Approved tx of acromegaly

Answer 10

Lanreotide

Question 11

Human menopausal gonadotropins

Answer 11

Menotropins

Question 12

urofollitropin

Answer 12

FSH

Question 13

Lutropin alfa

Answer 13

Recombinant human LH

Question 14

Choriogonadotropin alfa

Answer 14

Rh cg

Question 15

Gonadotropin clinical use

Answer 15

Anovulation
Female infertility
Hypogonadotropic hypogonadism male infertility
Assisted reproductive therapy

Question 16

Alternative for ovulation induction

Answer 16

Clomiphene

Question 17

Conventional therapy for male infertility

Answer 17

HCG

HMG

Question 18

Characteristics of ovarian hyperstimulation syndrome

Answer 18

Ovarian enlargement
Ascites
Hypovolemia

Question 19

Gnrh pulsatile vs sustained non pulsatile

Answer 19

Pulsatile - stimulate fsh and lh

Sustained non pulsatile - inhibit fsh and lh, for gonadal and ovarian suppression

Question 20

Acetate salt of synthetic human gnRH, pulsatile release

Answer 20

Gonadorelin

Question 21

Synthetic analogs of gnrh

Answer 21

Longer half life

Question 22

Biphasic response to continuous gonadorelin

Answer 22

Flare during first 7-10 days
Then
Receptor down regulation

Question 23

Clinical use of gonadotropin AND gonadorelin

Answer 23

Prevent premature lh surge and ovulation

Etc

Question 24

Endometriosis treatment

Answer 24

Leuprolide and sometng

Question 25

Uterine leiomyomata (fibrosis) treatment

Answer 25

Continuois gnrh agonist with iron supplement for 3-6 months

Question 26

Prostate cancer treatment

Answer 26

Continuous gnrh agonist AND flutamide (androgen antagonist)

Question 27

How to prevent tumor flare of trstosterone

Answer 27

Biclutamide (androgen antagonist)

Question 28

Preferred tx of breast cancer after mastectomy

Answer 28

Tamoxifen in premenopausal

Aromatase inhibitors in postmenopausal

Question 29

Controversial adjuvant tx for breast ca

Answer 29

Ovarian suppression or ovarian ablation

Question 30

Treatment for central precociouspuberty

Answer 30

Leuprolide
Histrelin
Nafarelin

Question 31

Gonadorelin toxicity

Answer 31

Something and Blindness

Question 32

gonadorelin analog in nasal form

Answer 32

Nafarelin

Question 33

Ganirelix

Cetrorelix

Answer 33

Controlled ovarian hyperstimulation

Question 34

Dextrirrlix???

Answer 34

Prostate cancer

Question 35

Dopamine agonists na ergot derivatives

Answer 35

Bromocriptine

Cabergoline

Question 36

Non ergot dopamine agonist

Answer 36

Quinagolide

Question 37

Dopamine agonist with longest duration of action

Answer 37

Cabergoline

Question 38

Dopamine agonist toxicity

Answer 38

Erythromelalgia etc

Question 39

Oxytocin effect at high concentrations

Answer 39

Weak adh action

Question 40

Oxytocin

Answer 40

toxicityexcessive uterine contraction
Excessive Fluid retention
Hypotension

Question 41

Oxytocin antagonist

Answer 41

Atosiban

Question 42

Long acting synthetic analog of vasopressin

Answer 42

Desmopressin

Question 43

Clinical use of desmopressin

Answer 43

Nocturnal enuresis in px with diabetes insipidus

Question 44

Vasopressin antagonist

Answer 44

Conivaptan

Tolvaptan