Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharma > PHARMA endocrine Drugs > Flashcards

PHARMA endocrine Drugs Flashcards

0
Q

Complex of rhIGF 1 and rhIGFBP 3

A

Mecasermin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Growth hormone side effect

A

Pseudotumor cerebri (intracranial hpn)
Scoliosis in children
Hyperglycemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Most important side effect of Mecasermin

A

Hypoglycemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Tx for GH resistant cases

A

Mecasermin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Novel GH receptor antagonist, for small gh-secreting adenomas

A

Pegvisomant (withpolyethyleneglycol)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Somatostatin analog

A

Octreotide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Advantage of octreotide vs somatostatin

A

Octreotide lasts 30x longer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Octreotide clinical use

A

For hormone secreting tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Diagnostic method to localize neuroendocrine tumors ha ing sst receptor

A

Somatostatin receptor scintigraphy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Other use of octreotide

A

Aute esophageal varices

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Approved tx of acromegaly

A

Lanreotide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Human menopausal gonadotropins

A

Menotropins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

urofollitropin

A

FSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Lutropin alfa

A

Recombinant human LH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Choriogonadotropin alfa

A

Rh cg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Gonadotropin clinical use

A

Anovulation
Female infertility
Hypogonadotropic hypogonadism male infertility
Assisted reproductive therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Alternative for ovulation induction

A

Clomiphene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Conventional therapy for male infertility

A

HCG

HMG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Characteristics of ovarian hyperstimulation syndrome

A

Ovarian enlargement
Ascites
Hypovolemia

19
Q

Gnrh pulsatile vs sustained non pulsatile

A

Pulsatile - stimulate fsh and lh

Sustained non pulsatile - inhibit fsh and lh, for gonadal and ovarian suppression

20
Q

Acetate salt of synthetic human gnRH, pulsatile release

A

Gonadorelin

21
Q

Synthetic analogs of gnrh

A

Longer half life

22
Q

Biphasic response to continuous gonadorelin

A

Flare during first 7-10 days
Then
Receptor down regulation

23
Q

Clinical use of gonadotropin AND gonadorelin

A

Prevent premature lh surge and ovulation

Etc

24
Q

Endometriosis treatment

A

Leuprolide and sometng

25
Q

Uterine leiomyomata (fibrosis) treatment

A

Continuois gnrh agonist with iron supplement for 3-6 months

26
Q

Prostate cancer treatment

A

Continuous gnrh agonist AND flutamide (androgen antagonist)

27
Q

How to prevent tumor flare of trstosterone

A

Biclutamide (androgen antagonist)

28
Q

Preferred tx of breast cancer after mastectomy

A

Tamoxifen in premenopausal

Aromatase inhibitors in postmenopausal

29
Q

Controversial adjuvant tx for breast ca

A

Ovarian suppression or ovarian ablation

30
Q

Treatment for central precociouspuberty

A

Leuprolide
Histrelin
Nafarelin

31
Q

Gonadorelin toxicity

A

Something and Blindness

32
Q

gonadorelin analog in nasal form

A

Nafarelin

33
Q

Ganirelix

Cetrorelix

A

Controlled ovarian hyperstimulation

34
Q

Dextrirrlix???

A

Prostate cancer

35
Q

Dopamine agonists na ergot derivatives

A

Bromocriptine

Cabergoline

36
Q

Non ergot dopamine agonist

A

Quinagolide

37
Q

Dopamine agonist with longest duration of action

A

Cabergoline

38
Q

Dopamine agonist toxicity

A

Erythromelalgia etc

39
Q

Oxytocin effect at high concentrations

A

Weak adh action

40
Q

Oxytocin

A

toxicityexcessive uterine contraction
Excessive Fluid retention
Hypotension

41
Q

Oxytocin antagonist

A

Atosiban

42
Q

Long acting synthetic analog of vasopressin

A

Desmopressin

43
Q

Clinical use of desmopressin

A

Nocturnal enuresis in px with diabetes insipidus

44
Q

Vasopressin antagonist

A

Conivaptan

Tolvaptan

Pharma (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions