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Pharma > Cell Wall Inhibitors > Flashcards

Cell Wall Inhibitors Flashcards

0
Q

Penicillin moa

A

Inhibit transpeptidation (cross linking of peptide side chain with pentaglycine bridges in cell wall)

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1
Q

3 classifications of penicillins

A

Penicillins
Anti staph penicillins
Extended spectrum penicillins

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2
Q

Penicillin nucleus

A

6 amino penicillinic acid nucleus

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3
Q

Penicillin whose absorption is not impaired by food intake

A

Amoxicillin

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4
Q

Penicillin na excreted in the bile

A

Nafcillin

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5
Q

Penicillins nae xcreted ink idney and bile

A

Oxacillin, dicloxacillin and colxacillin

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6
Q

No longer used because of acute tubular necrosis

A

Methicillin

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7
Q

Oral form of penicillin

A

Penicillin v

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8
Q

For Mild to moderate staph infections

A

Isoxazolyl oenicillins - oxacillin, cloxacillin and dicloxacillin

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9
Q

For serious staph infections

A

Oxacillin (in higher doses) and nafcillin

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10
Q

Repository forms of penicillin

A

Benzathine penicillin

Procaine penicillin

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11
Q

4 beta lactamase resistant penicillins

A 
Nafcillin
Oxacillin
Dicloxacillin
Methicillin
(Cloxacillin)
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12
Q

4 extended spectrum penicillins

A

Aminopenicillins - amoxicillin, ampicillin, carboxypenicillin ureidopenicillin

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13
Q

Penicillin for shigellosis

A

Ampicillin

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14
Q

First anti pseudomonal carboxypenicillin, now obsolete

A

Carbenicillin

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15
Q

Anti pseudomonal penicillins

A 
Carboxypenicillin
Ureidopenicillin (use with aminoglycosides
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16
Q

Amoxicillin + clavulanic acid

A

Augmentin

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17
Q

Ampicillin + clavulanic acid

A

Co amoxiclav

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18
Q

Benzathine 1.2 M units is for?

A

Beta hemolytic strep pharyngitis

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19
Q

Benzathine 2.0 M units

A

Syphilis

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20
Q

Cephalosporin nucleus

A

7-aminocephalosporanic acid

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21
Q

First generation cephalosporins

A

CefAZOLin
CefALEXin
(Azole si alex)

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22
Q

Second gen cephalosporin

A

Cefuroxime
Cefoxitin
Cefmetazole
Cefotetan

23
Q

Third generation cephalosporin

A 
Cefixime
Ceftriaxone
Cefotaxime
Ceftazidime
Cefoperazone
Ceftizoxime
24
Q

Fourth gen cephalosporin

A

Cefepime

25
Q

Methylthiotetrazole group of cephalosporins

A

CefAMANDOle
CefMETazole
CefOTEtan
CefOPERAzone

Amando met ote (at the) opera

26
Q

Anti pseudomonal third gen cephalo

A

Ceftazidime

CefOPERAzone

27
Q

Ceftizoxime clinical use

A

B. Fragilis

28
Q

DOC for gonorrhea

A

Cefixime oral

Ceftriaxone parenteral

29
Q

Adverse effects of methylthiotetrazole group

A

Hypoprothrombinemia
Bleeding
Disulfiram like rxns

30
Q

Monobactams spectrum of activity is limited to

A

Gram neg rods

31
Q

Monobactam given to allergic to penicillin

A

Aztreonam

32
Q

3 suicidal inhibitors

A

Clavulanic acid
Sulbactam
Tazobactam

33
Q

Can stand alone if you want to treat difficult infections

A

Carbapenems

34
Q

Doc for enterobacter infection

A

Carbapenem

35
Q

4 carbapenems

A

Doripenem
Imipenem
Meropenem
Ertapenem

36
Q

Doc for surgical prophylaxis alternative to antistaph penicillins

A

Imipenem

37
Q

Active only on gram positive except for flavobacterium

A

Vancomycin

38
Q

4 glycopeptide antibiotics

A

Vancomycin
Teicoplanin
Telavancin
Dalbavancin

39
Q

Vancomycin indication

A

For mrsa staph infection

40
Q

Vancomycin only route of administration

A

Via IV only because it is poorly absorbed

41
Q

2nd doc for c difficile enterocolitis

A

Vancomycin

42
Q

Vancomycin adr

A

Red neck syndrome due to histamine release

43
Q

Longer half life than vancomycin but same moa

A

Teicoplanin

44
Q

Chemically modified vancomycin

A

Telavancin

45
Q

Chemically modified teicoplanin

A

Dalbavancin

46
Q

For simple LUTI even for pregnant

A

Fosfomycin

47
Q

Fosfomycin moa

A

Inhibits enolpyruvTe transferase

48
Q

Daptomycin moa

A

Calcium dependent lipid tail insertion forming porin channels that cause k efflux and cell death

49
Q

Moa is to interfere with dephosphorylation in cycling of lipid carrier (c55 isoprenyl pyrophosphate)

A

Bacitracin

50
Q

Bacitracin use

A

For surface lesions with mixed flora, topical

51
Q

Inhibits alanine racemase and ligase enzymes

A

Cycloserine

52
Q

Cycloserine adr

A

Dose related cns toxicity

53
Q

Third gen cephalosporins that cant cross bbb

A

Cefoperazone

Cefixime

54
Q

Difference of cephazolin and cephalexin

A

CephAZOLin is IV

CephALEXin is oral

55
Q

The only second gen cephalosporin that can cross bbb

A

Cefuroxime axetil

56
Q

Second gen ceph for peritonitis, diverticulitis and anaerobes

A

Cephamycins – ceFOXitin, cefOTEtan, cefMETazole

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