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Cell Wall Inhibitors Flashcards

0
Q

Penicillin moa

A

Inhibit transpeptidation (cross linking of peptide side chain with pentaglycine bridges in cell wall)

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1
Q

3 classifications of penicillins

A

Penicillins
Anti staph penicillins
Extended spectrum penicillins

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2
Q

Penicillin nucleus

A

6 amino penicillinic acid nucleus

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3
Q

Penicillin whose absorption is not impaired by food intake

A

Amoxicillin

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4
Q

Penicillin na excreted in the bile

A

Nafcillin

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5
Q

Penicillins nae xcreted ink idney and bile

A

Oxacillin, dicloxacillin and colxacillin

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6
Q

No longer used because of acute tubular necrosis

A

Methicillin

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7
Q

Oral form of penicillin

A

Penicillin v

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8
Q

For Mild to moderate staph infections

A

Isoxazolyl oenicillins - oxacillin, cloxacillin and dicloxacillin

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9
Q

For serious staph infections

A

Oxacillin (in higher doses) and nafcillin

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10
Q

Repository forms of penicillin

A

Benzathine penicillin

Procaine penicillin

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11
Q

4 beta lactamase resistant penicillins

A 
Nafcillin
Oxacillin
Dicloxacillin
Methicillin
(Cloxacillin)
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12
Q

4 extended spectrum penicillins

A

Aminopenicillins - amoxicillin, ampicillin, carboxypenicillin ureidopenicillin

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13
Q

Penicillin for shigellosis

A

Ampicillin

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14
Q

First anti pseudomonal carboxypenicillin, now obsolete

A

Carbenicillin

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15
Q

Anti pseudomonal penicillins

A 
Carboxypenicillin
Ureidopenicillin (use with aminoglycosides
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16
Q

Amoxicillin + clavulanic acid

A

Augmentin

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17
Q

Ampicillin + clavulanic acid

A

Co amoxiclav

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18
Q

Benzathine 1.2 M units is for?

A

Beta hemolytic strep pharyngitis

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19
Q

Benzathine 2.0 M units

A

Syphilis

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20
Q

Cephalosporin nucleus

A

7-aminocephalosporanic acid

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21
Q

First generation cephalosporins

A

CefAZOLin
CefALEXin
(Azole si alex)

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22
Q

Second gen cephalosporin

A

Cefuroxime
Cefoxitin
Cefmetazole
Cefotetan

23
Q

Third generation cephalosporin

A 
Cefixime
Ceftriaxone
Cefotaxime
Ceftazidime
Cefoperazone
Ceftizoxime
24
Fourth gen cephalosporin
Cefepime
25
Methylthiotetrazole group of cephalosporins
CefAMANDOle CefMETazole CefOTEtan CefOPERAzone Amando met ote (at the) opera
26
Anti pseudomonal third gen cephalo
Ceftazidime | CefOPERAzone
27
Ceftizoxime clinical use
B. Fragilis
28
DOC for gonorrhea
Cefixime oral | Ceftriaxone parenteral
29
Adverse effects of methylthiotetrazole group
Hypoprothrombinemia Bleeding Disulfiram like rxns
30
Monobactams spectrum of activity is limited to
Gram neg rods
31
Monobactam given to allergic to penicillin
Aztreonam
32
3 suicidal inhibitors
Clavulanic acid Sulbactam Tazobactam
33
Can stand alone if you want to treat difficult infections
Carbapenems
34
Doc for enterobacter infection
Carbapenem
35
4 carbapenems
Doripenem Imipenem Meropenem Ertapenem
36
Doc for surgical prophylaxis alternative to antistaph penicillins
Imipenem
37
Active only on gram positive except for flavobacterium
Vancomycin
38
4 glycopeptide antibiotics
Vancomycin Teicoplanin Telavancin Dalbavancin
39
Vancomycin indication
For mrsa staph infection
40
Vancomycin only route of administration
Via IV only because it is poorly absorbed
41
2nd doc for c difficile enterocolitis
Vancomycin
42
Vancomycin adr
Red neck syndrome due to histamine release
43
Longer half life than vancomycin but same moa
Teicoplanin
44
Chemically modified vancomycin
Telavancin
45
Chemically modified teicoplanin
Dalbavancin
46
For simple LUTI even for pregnant
Fosfomycin
47
Fosfomycin moa
Inhibits enolpyruvTe transferase
48
Daptomycin moa
Calcium dependent lipid tail insertion forming porin channels that cause k efflux and cell death
49
Moa is to interfere with dephosphorylation in cycling of lipid carrier (c55 isoprenyl pyrophosphate)
Bacitracin
50
Bacitracin use
For surface lesions with mixed flora, topical
51
Inhibits alanine racemase and ligase enzymes
Cycloserine
52
Cycloserine adr
Dose related cns toxicity
53
Third gen cephalosporins that cant cross bbb
Cefoperazone | Cefixime
54
Difference of cephazolin and cephalexin
CephAZOLin is IV | CephALEXin is oral
55
The only second gen cephalosporin that can cross bbb
Cefuroxime axetil
56
Second gen ceph for peritonitis, diverticulitis and anaerobes
Cephamycins -- ceFOXitin, cefOTEtan, cefMETazole

Pharma (20 decks)

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