PHARMA anti Cancer Drugs Flashcards
Determines the maximum growth rate of a tumr, not drug sensitivity
Cell cycle time
Proteins in control of cell growth
Class i - growth factors Class ii - Receptors for gf and hormones Class iii - Intracellular signal transducers Class iv - Nuclear transcription factors Class v - Cell cycle control proteins
2 ways to classify drugs
1) cell cycle specificity
2) mechanism of action
Drugs specific on mitosis
Taxanes, vincas, anti microtubule inhibitor
G1 specific drugs
AsparaginSe
Prednisone
G1 s specific
Etoposide
G1 s specific
Cladribine
S lhase specific
Antimetabolites
Hydroxyurea
G2 specific
Bleomycin
Antimetabolites
Capecitabine cladribine cutarabine fludarabine gemcitabine Etc
Antitumor antibiotic
Bleomycin
Vinca alkaloids
Vinblastine vincristine vinorelbine
Epipodophyllotoxins
Etoposide teniposide
Taxanes
Paclitaxel docetaxel
Alkylating agents (non cell cycle specific)
Busulfan Carmustine Cyclophosphamide Lomustine Mechlorethamine Melohalan Thiotep
Anthracyclines (non cell cycle specific)
DaunoRUBICIN
DoxoRUBICIN
EpiRUBICIN
Mitoxantrone
Antitumor antibiotics (non cell cycle specific)
Dactinomycin mitomycin
Campothecins (non cell cycle specific)
Irinotecan
Topotecan
Platinum analogs (non cell cycle specific)
CarboPLATIN
cisPLATIN
oxaliPLATIN
Anti parasitic drug combined with anti cancers to enhance biochemical effect
Levamisole
Nephrotoxic -
Methotrexate
Cisplatin
Streptozocin
Reduce when there is hepatic impairment
Vinca and ??
4 general adverse effects of all a ti cancer
Nausea vomiting
Mucositis stomatitis
Baldness
Myelosuppression
Alkylating agents
Nitrogen mustard Ethylenimine Alkyl sulfonate Triazene Platinum
Niyrosoureas
CarMUSTINE
loMUSTINE
seMUSTINE
Streptozocin - newest
Anti metabolites
Anti folic a id, antipurine, Nti pyrimidines
Antibiotics
Anthracyclines - rubicin DactinoMYCIN plicamycin Mitomycin Bleomycin
Hormonal
Tamoxifen
Flutamidd
Gnrh Agonists
Aromatase inhibitors
Natural produ ts
Vinca alkaloids
Epipodophyllotoxin
Camptothecins
Taxanes
Misc
Amifostine
Hydroxyurea
Etc
Alkylating agents MOA
Nucleotides to DNA
Attachment of alkyl groups to DNA bases to form fragmented DNA s
Can also form cross bridges and cause mispairing
With direct vessicant effects
Alkylating agents esp nitrogen mustards.. Can damage tissues so give drug very slowly
Alkylating agents na irritant
Cisplatin
Dacarbazine
Cyclophosphamide clinical use
Breast, leukemias
Chlorambucil
Chronic lymphocytic leukemia
Busulfan
Chronic myeloid leukemia
Oxaliplatin
Colon CA
Hematopoietic toxicity of cyclophosphamide ifosfamide
Platelet sparing
Hematopoietic toxicity of busulfan
Relative lymphocyte sparing
Carboplastin Hematopoietic toxicity of
Cisplatin.
More of platelets
Cyclophosphamide GIT ae
Severe NV
Busulfan AE
Interstitial pneumonitis, fibrosis
Cyclophosphamide ae
Alopecia
Nephrotoxic alkylating agents
Cysplatin
Carboplatin
Cyclophosphamide
Ototoxic
Cisplatin
Carboplatin IRREVERSIBLE
Neuropathy AE
Cisplatin
Oxaliplatin REVERSIBLE
NITROSOUREAS moa
Bifunctional alkylating agent capable of alkylation and carbamoylation
Only one that can pass BBB in great amounts, with delayed myelosuppressive AEs..
Nitrosoureas
Nitrosourea na irritant and pulmonary side effects
Carmustine
For insulin secreting islet cell pancreatic carcinoma non hodgkins lymphoma
Strepto??
anti folate example
Methotrexate
Pyrimidine analogs
Fluoroura capecitabine
Anti ppurine
Thioguanine
Mercaptopurine
Antimetabolites with both oral and iv preps
Methotrexate
Mercaptopurine
Methotrexate
Acute lymphocytic leukemia
Mercaptopurine
Childhood acute leukemia
5FU
Breast and colorctal
Cytarabine
Acute myelogenous leukemia
Methotrexate ae
Megaloblastic anemia
Methotrexate 5FU and Cytarabine AE
Megaloblastic anemia
Act primarily through their effect on microtubular protein wti ha resultant metaphase arrest and inhibition of mitosis
Natural products (mitotic disrupters)
Most common AE of natural products
AREFLEXIA (neurotoxic)
Vincristine use
ALL
Microtubule polymer stabilizers
Taxanes - paclitaxel, docetaxel
Toxicity of microtubule polymer stanilizer
Bone marrow suppression
Paclitaxel use
Breast ca
Epipodophyllotoxins MOA
Topoisomerase ii inhibitors
Topoisomerase iii nhibitors AE
Diarrhea
Etoposide use
Lung ca
Teniposide use
Acute lymphoblastic leukemia
Camptothecins use
Inhibit topoisomerase i
Topootecan use
Lung
Irinotecan
Colorectal ca
Most common anthracycline antibiotic
Doxorubicin
Antibiotic that can cross bbb a little
Bleomycin
Antibiotics ae doxorubicin daunorubicin
Cardiotoxicity
Bleomycin ae
Pulmonary fibrosis
Plicamycin
Hepatotoxicity
Antibiotics moa
Blocks dna to rna
Doxorubicin use
Marami
Androgen antagonist
Flutamide
Estrogen antagonist
Tamoxifen
Aromatase inhibitor
Anastrozole
Gnrh inhibitor
Leuprolide
Peptide hormone inhibitor
Octreotide
Tampxifen
Breast ca
Flutamide
Prostatic ca
Anastrozole
advanced er pr + ?
Flutamide ae
Hot flashes impotence libido
Fluoxymestetone
Chooestatic jaundice
Cytoprotective from effects of cisplatin
Amifostine
Colon cancer drug combinations
Folfiri
Folfox
Capeox
Capeox wi th or without bevacizumab
Leukemia ALL drug combi
Vincristine and prednisone
Efc
Breast drug combi
CAF
AC
CMFP
Etc
Lung drug combi
Etoppside plus cisplatin
Aml combi
Cytarabine daunorubicin
Helps prevent heart damage
Dexrazoxaone??