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PHARMA anti Cancer Drugs Flashcards

0
Q

Determines the maximum growth rate of a tumr, not drug sensitivity

A

Cell cycle time

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1
Q

Proteins in control of cell growth

A 
Class i - growth factors
Class ii - Receptors for gf and hormones
Class iii - Intracellular signal transducers
Class iv - Nuclear transcription factors
Class v - Cell cycle control proteins
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2
Q

2 ways to classify drugs

A

1) cell cycle specificity

2) mechanism of action

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3
Q

Drugs specific on mitosis

A

Taxanes, vincas, anti microtubule inhibitor

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4
Q

G1 specific drugs

A

AsparaginSe

Prednisone

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5
Q

G1 s specific

A

Etoposide

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6
Q

G1 s specific

A

Cladribine

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7
Q

S lhase specific

A

Antimetabolites

Hydroxyurea

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8
Q

G2 specific

A

Bleomycin

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9
Q

Antimetabolites

A 
Capecitabine 
cladribine
 cutarabine 
fludarabine 
gemcitabine
Etc
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10
Q

Antitumor antibiotic

A

Bleomycin

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11
Q

Vinca alkaloids

A

Vinblastine vincristine vinorelbine

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12
Q

Epipodophyllotoxins

A

Etoposide teniposide

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13
Q

Taxanes

A

Paclitaxel docetaxel

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14
Q

Alkylating agents (non cell cycle specific)

A 
Busulfan
Carmustine
Cyclophosphamide
Lomustine
Mechlorethamine
Melohalan
Thiotep
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15
Q

Anthracyclines (non cell cycle specific)

A

DaunoRUBICIN
DoxoRUBICIN
EpiRUBICIN
Mitoxantrone

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16
Q

Antitumor antibiotics (non cell cycle specific)

A

Dactinomycin mitomycin

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17
Q

Campothecins (non cell cycle specific)

A

Irinotecan

Topotecan

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18
Q

Platinum analogs (non cell cycle specific)

A

CarboPLATIN
cisPLATIN
oxaliPLATIN

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19
Q

Anti parasitic drug combined with anti cancers to enhance biochemical effect

A

Levamisole

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20
Q

Nephrotoxic -

A

Methotrexate
Cisplatin
Streptozocin

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21
Q

Reduce when there is hepatic impairment

A

Vinca and ??

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22
Q

4 general adverse effects of all a ti cancer

A

Nausea vomiting
Mucositis stomatitis
Baldness
Myelosuppression

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23
Q

Alkylating agents

A 
Nitrogen mustard
Ethylenimine
Alkyl sulfonate
Triazene 
Platinum
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24
Q

Niyrosoureas

A

CarMUSTINE
loMUSTINE
seMUSTINE
Streptozocin - newest

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25
Q

Anti metabolites

A

Anti folic a id, antipurine, Nti pyrimidines

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26
Q

Antibiotics

A 
Anthracyclines - rubicin
DactinoMYCIN
plicamycin
Mitomycin
Bleomycin
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27
Q

Hormonal

A

Tamoxifen
Flutamidd
Gnrh Agonists
Aromatase inhibitors

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28
Q

Natural produ ts

A

Vinca alkaloids
Epipodophyllotoxin
Camptothecins
Taxanes

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29
Q

Misc

A

Amifostine
Hydroxyurea
Etc

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30
Q

Alkylating agents MOA

A

Nucleotides to DNA
Attachment of alkyl groups to DNA bases to form fragmented DNA s

Can also form cross bridges and cause mispairing

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31
Q

With direct vessicant effects

A

Alkylating agents esp nitrogen mustards.. Can damage tissues so give drug very slowly

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32
Q

Alkylating agents na irritant

A

Cisplatin

Dacarbazine

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33
Q

Cyclophosphamide clinical use

A

Breast, leukemias

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34
Q

Chlorambucil

A

Chronic lymphocytic leukemia

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35
Q

Busulfan

A

Chronic myeloid leukemia

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36
Q

Oxaliplatin

A

Colon CA

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37
Q

Hematopoietic toxicity of cyclophosphamide ifosfamide

A

Platelet sparing

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38
Q

Hematopoietic toxicity of busulfan

A

Relative lymphocyte sparing

39
Q

Carboplastin Hematopoietic toxicity of

Cisplatin.

A

More of platelets

40
Q

Cyclophosphamide GIT ae

41
Q

Busulfan AE

A

Interstitial pneumonitis, fibrosis

42
Q

Cyclophosphamide ae

43
Q

Nephrotoxic alkylating agents

A

Cysplatin
Carboplatin
Cyclophosphamide

44
Q

Ototoxic

A

Cisplatin

Carboplatin IRREVERSIBLE

45
Q

Neuropathy AE

A

Cisplatin

Oxaliplatin REVERSIBLE

46
Q

NITROSOUREAS moa

A

Bifunctional alkylating agent capable of alkylation and carbamoylation

47
Q

Only one that can pass BBB in great amounts, with delayed myelosuppressive AEs..

A

Nitrosoureas

48
Q

Nitrosourea na irritant and pulmonary side effects

A

Carmustine

49
Q

For insulin secreting islet cell pancreatic carcinoma non hodgkins lymphoma

50
Q

anti folate example

A

Methotrexate

51
Q

Pyrimidine analogs

A

Fluoroura capecitabine

52
Q

Anti ppurine

A

Thioguanine

Mercaptopurine

53
Q

Antimetabolites with both oral and iv preps

A

Methotrexate

Mercaptopurine

54
Q

Methotrexate

A

Acute lymphocytic leukemia

55
Q

Mercaptopurine

A

Childhood acute leukemia

56
Q

5FU

A

Breast and colorctal

57
Q

Cytarabine

A

Acute myelogenous leukemia

58
Q

Methotrexate ae

A

Megaloblastic anemia

59
Q

Methotrexate 5FU and Cytarabine AE

A

Megaloblastic anemia

60
Q

Act primarily through their effect on microtubular protein wti ha resultant metaphase arrest and inhibition of mitosis

A

Natural products (mitotic disrupters)

61
Q

Most common AE of natural products

A

AREFLEXIA (neurotoxic)

62
Q

Vincristine use

63
Q

Microtubule polymer stabilizers

A

Taxanes - paclitaxel, docetaxel

64
Q

Toxicity of microtubule polymer stanilizer

A

Bone marrow suppression

65
Q

Paclitaxel use

66
Q

Epipodophyllotoxins MOA

A

Topoisomerase ii inhibitors

67
Q

Topoisomerase iii nhibitors AE

68
Q

Etoposide use

69
Q

Teniposide use

A

Acute lymphoblastic leukemia

70
Q

Camptothecins use

A

Inhibit topoisomerase i

71
Q

Topootecan use

72
Q

Irinotecan

A

Colorectal ca

73
Q

Most common anthracycline antibiotic

A

Doxorubicin

74
Q

Antibiotic that can cross bbb a little

75
Q

Antibiotics ae doxorubicin daunorubicin

A

Cardiotoxicity

76
Q

Bleomycin ae

A

Pulmonary fibrosis

77
Q

Plicamycin

A

Hepatotoxicity

78
Q

Antibiotics moa

A

Blocks dna to rna

79
Q

Doxorubicin use

80
Q

Androgen antagonist

81
Q

Estrogen antagonist

82
Q

Aromatase inhibitor

A

Anastrozole

83
Q

Gnrh inhibitor

A

Leuprolide

84
Q

Peptide hormone inhibitor

A

Octreotide

85
Q

Tampxifen

86
Q

Flutamide

A

Prostatic ca

87
Q

Anastrozole

A

advanced er pr + ?

88
Q

Flutamide ae

A

Hot flashes impotence libido

89
Q

Fluoxymestetone

A

Chooestatic jaundice

90
Q

Cytoprotective from effects of cisplatin

A

Amifostine

91
Q

Colon cancer drug combinations

A

Folfiri
Folfox
Capeox
Capeox wi th or without bevacizumab

92
Q

Leukemia ALL drug combi

A

Vincristine and prednisone

Efc

93
Q

Breast drug combi

A

CAF
AC
CMFP
Etc

94
Q

Lung drug combi

A

Etoppside plus cisplatin

95
Q

Aml combi

A

Cytarabine daunorubicin

96
Q

Helps prevent heart damage

A

Dexrazoxaone??

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