PHARMA antipsychotics Flashcards
1 Chlorpromazine (Aliphatic)
A Phenothiazine Derivatives Antipsychotic
2 Thioridazine (Piperidine)
A Phenothiazine Derivatives Antipsychotic
3 Fluphenazine (Piperazine)
A Phenothiazine Derivatives Antipsychotic
1 Haloperidol
B Butyrophenone Derivatives Antipsychotic
1 Thiothixene
C Thioxanthene Derivative Antipsychotic
1 Pimozide
D Miscellaneous Structures Antipsychotic
2 Molindone
D Miscellaneous Structures Antipsychotic
1 Clozapine
E Atypical Antipsychotic
2 Asenapine
E Atypical Antipsychotic
3 Olanzapine
E Atypical Antipsychotic
4 Quetiapine
E Atypical Antipsychotic
5 Zotepine
E Atypical Antipsychotic
6 Paliperidone
E Atypical Antipsychotic
7 Risperidone
E Atypical Antipsychotic
8 Ziprasidone
E Atypical Antipsychotic
9Aripiprazole
E Atypical Antipsychotic
10 Sertindole
E Atypical Antipsychotic
Earliest to peak
Risperidone 1-1.5 hrs
Shortest half life
Risperidone 3-4 hrs
Highest Vd
Olanzapine 10-20 L/kg
Highest protein binding
Ziprasidone >99%
MOA of antipsychotics
antagonist or partial agonist at D2 dopamine receptors
Mesolimbic-Mesocortical Pathway
behavior and psychosis
Nigrostriatal Pathway
coordination of voluntary movement
Tuberoinfundibular Pathway
inhibition of prolactin secretion
Medullary Periventricular Pathway
may be involved in eating behavior
Incertohypothalamic Pathway
appears to regulate the anticipatory motivational phase of copulatory behavior in rats
orthostatic hypotension, impaired ejaculation, deposits in lens
Chlorpromazine
deposits in retina; slightest EPS
Thiodiazine
tardive dyskinesia
Fluphenazine
no weight gain
Loxapine
severe EPS; cardiotoxicity (torsades)
Haloperidol
EPS
D2
Sedation
a1 H1
Anticholinergic
M1
Orthostatic hypotension
a1
Weight gain
5HT
Anti emesis
Prochlorperazine
Pruritus
Quetiapine
Neurolept Anesthesia
Droperidol + Fentanyl
1 Carbamazepine
Anticonvulsant under Mood Stabilizing Drugs
2 Valproic Acid
Anticonvulsant under Mood Stabilizing Drugs
Carbamazepine MOA
inositol inhibition
Valproic Acid MOA
inositol inhibition; GSK-3 inhibition