PHARMA antipsychotics Flashcards by aura a

Q

1 Chlorpromazine (Aliphatic)

A

A Phenothiazine Derivatives Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

2 Thioridazine (Piperidine)

A

A Phenothiazine Derivatives Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

3 Fluphenazine (Piperazine)

A

A Phenothiazine Derivatives Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

1 Haloperidol

A

B Butyrophenone Derivatives Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

1 Thiothixene

A

C Thioxanthene Derivative Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

1 Pimozide

A

D Miscellaneous Structures Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

2 Molindone

A

D Miscellaneous Structures Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

1 Clozapine

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

2 Asenapine

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

3 Olanzapine

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

4 Quetiapine

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

5 Zotepine

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

6 Paliperidone

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

7 Risperidone

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

8 Ziprasidone

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

9Aripiprazole

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

10 Sertindole

A

E Atypical Antipsychotic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Earliest to peak

A

Risperidone 1-1.5 hrs

Q

Shortest half life

A

Risperidone 3-4 hrs

Q

Highest Vd

A

Olanzapine 10-20 L/kg

Q

Highest protein binding

A

Ziprasidone >99%

Q

MOA of antipsychotics

A

antagonist or partial agonist at D2 dopamine receptors

Q

Mesolimbic-Mesocortical Pathway

A

behavior and psychosis

Q

Nigrostriatal Pathway

A

coordination of voluntary movement

Tuberoinfundibular Pathway

inhibition of prolactin secretion

Medullary Periventricular Pathway

may be involved in eating behavior

Incertohypothalamic Pathway

appears to regulate the anticipatory motivational phase of copulatory behavior in rats

orthostatic hypotension, impaired ejaculation, deposits in lens

Chlorpromazine

deposits in retina; slightest EPS

Thiodiazine

tardive dyskinesia

Fluphenazine

no weight gain

Loxapine

severe EPS; cardiotoxicity (torsades)

Haloperidol

EPS

D2

Sedation

a1 H1

Anticholinergic

M1

Orthostatic hypotension

a1

Weight gain

5HT

Anti emesis

Prochlorperazine

Pruritus

Quetiapine

Neurolept Anesthesia

Droperidol + Fentanyl

1 Carbamazepine

Anticonvulsant under Mood Stabilizing Drugs

2 Valproic Acid

Anticonvulsant under Mood Stabilizing Drugs

Carbamazepine MOA

inositol inhibition

Valproic Acid MOA

inositol inhibition; GSK-3 inhibition