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Pharma > PHARMA antipsychotics > Flashcards

PHARMA antipsychotics Flashcards

1
Q

1 Chlorpromazine (Aliphatic)

A

A Phenothiazine Derivatives Antipsychotic

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2
Q

2 Thioridazine (Piperidine)

A

A Phenothiazine Derivatives Antipsychotic

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3
Q

3 Fluphenazine (Piperazine)

A

A Phenothiazine Derivatives Antipsychotic

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4
Q

1 Haloperidol

A

B Butyrophenone Derivatives Antipsychotic

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5
Q

1 Thiothixene

A

C Thioxanthene Derivative Antipsychotic

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6
Q

1 Pimozide

A

D Miscellaneous Structures Antipsychotic

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7
Q

2 Molindone

A

D Miscellaneous Structures Antipsychotic

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8
Q

1 Clozapine

A

E Atypical Antipsychotic

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9
Q

2 Asenapine

A

E Atypical Antipsychotic

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10
Q

3 Olanzapine

A

E Atypical Antipsychotic

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11
Q

4 Quetiapine

A

E Atypical Antipsychotic

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12
Q

5 Zotepine

A

E Atypical Antipsychotic

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13
Q

6 Paliperidone

A

E Atypical Antipsychotic

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14
Q

7 Risperidone

A

E Atypical Antipsychotic

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15
Q

8 Ziprasidone

A

E Atypical Antipsychotic

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16
Q

9Aripiprazole

A

E Atypical Antipsychotic

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17
Q

10 Sertindole

A

E Atypical Antipsychotic

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18
Q

Earliest to peak

A

Risperidone 1-1.5 hrs

19
Q

Shortest half life

A

Risperidone 3-4 hrs

20
Q

Highest Vd

A

Olanzapine 10-20 L/kg

21
Q

Highest protein binding

A

Ziprasidone >99%

22
Q

MOA of antipsychotics

A

antagonist or partial agonist at D2 dopamine receptors

23
Q

Mesolimbic-Mesocortical Pathway

A

behavior and psychosis

24
Q

Nigrostriatal Pathway

A

coordination of voluntary movement

25
Q

Tuberoinfundibular Pathway

A

inhibition of prolactin secretion

26
Q

Medullary Periventricular Pathway

A

may be involved in eating behavior

27
Q

Incertohypothalamic Pathway

A

appears to regulate the anticipatory motivational phase of copulatory behavior in rats

28
Q

orthostatic hypotension, impaired ejaculation, deposits in lens

A

Chlorpromazine

29
Q

deposits in retina; slightest EPS

A

Thiodiazine

30
Q

tardive dyskinesia

A

Fluphenazine

31
Q

no weight gain

A

Loxapine

32
Q

severe EPS; cardiotoxicity (torsades)

A

Haloperidol

33
Q

EPS

A

D2

34
Q

Sedation

A

a1 H1

35
Q

Anticholinergic

A

M1

36
Q

Orthostatic hypotension

A

a1

37
Q

Weight gain

A

5HT

38
Q

Anti emesis

A

Prochlorperazine

39
Q

Pruritus

A

Quetiapine

40
Q

Neurolept Anesthesia

A

Droperidol + Fentanyl

41
Q

1 Carbamazepine

A

Anticonvulsant under Mood Stabilizing Drugs

42
Q

2 Valproic Acid

A

Anticonvulsant under Mood Stabilizing Drugs

43
Q

Carbamazepine MOA

A

inositol inhibition

44
Q

Valproic Acid MOA

A

inositol inhibition; GSK-3 inhibition

Pharma (20 decks)

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