PHARMA anti Virals

Question 0

Blocker of penetration

Answer 0

Interferon alpha

Question 1

Blockers of viral attachment and entry

Answer 1

ENMADOPA
Enfuviritide
Maraviroc
Doconasol 
Palivizuma

Question 2

Blocks uncoating

Answer 2

Amantidine
Rimantidine
(Anti influenzas)

Question 3

Blockers of nuckeid acid synthesis

Answer 3

NRTIs
NNRTIs
Acyclovir
Foscarnet

Question 4

Blockers of late protein synthesis and processing

Answer 4

Protease inhibitors
Ritonavir
Indinavir

Question 5

Blocker of viral release

Answer 5

Neuraminidase inhibitors
Zanavidir
Oselnativir ??

Question 6

Monophosphorylated by thymidine kinase

Answer 6

Acyclovir
Valacyclovir
Famciclovir

Question 7

Acyclovir moa

Answer 7

Competitive inhibition of viral dna polymerase

Chain termination

Question 8

L valyl ester ofadcyclovir with higher bioavailability

Answer 8

Valacyclovir

Question 9

Prodrug of penciclovir that DOES NOT cause chain termination

Answer 9

Famciclovir

Question 10

Topical cream that prevents viral entry

Answer 10

Doconasol

Question 11

Phosphorykated intracellularly by HOST ENZYMES, competes with thymidine triphosphate

Answer 11

Trifluridine

Question 12

Trifluridine use

Answer 12

Keratoconjunctivitis

Keratitis

Question 13

Three anti cmv agents

Answer 13

Ganciclovir
Foscarnet
Cidofovir

Question 14

Phosphorylated by viral PHOSPHOTRANSRASE, fir cmv inducing retinitis

Answer 14

Ganciclovir

Question 15

Not an antimetabolite, blocks pyrophosphate binding sites of enzymes

Answer 15

Foscarnet

Question 16

With activity against tk- strains

Answer 16

Trifluridine
Foscarnet
Cidofovir

Question 17

Cytosine nucleotide analog, potent inhibitor and substrate for viral dna polymerase

Answer 17

Cidofovir

Question 18

Structural analogs that cause COMPETITIVE inhibition of hiv 1 reverse transcriptase

Answer 18

NRTIs

Question 19

5 examples of NRTIs

Answer 19

Zidovudine - prototype
Didanosine - pancreatitis
Zalcitabine - neutropenia
Stavudine - myelosuppression less than azt
Lamivudine - for hepa B

Question 20

Binds directly to reverse transcriptase in an ALLOSTERIC MANNER

Answer 20

NNRTIs

Question 21

2 examples of nnrtis

Answer 21

Delavirdine

Nevirapine

Question 22

Protease inhibitors

Answer 22

Ritonavir

Indinavir

Question 23

PI that increases effect of dronabinol

Answer 23

Ritonavir

Question 24

PI with lesssdideedffects

Answer 24

Indinavir

Question 25

Protease inhibitor side effect

Answer 25

Fat redistribution

Question 26

Entry inhibitors / fusion inhibitors

Answer 26

Enfuvirtide | Maraviroc

Question 27

Binds to gp41 subunit of envelope glycoprotein, can be given SQ

Answer 27

Enfuviritide

Question 28

CCR5 Receptor antagonist, tropism testing needed

Answer 28

Maraviroc

Question 29

Integrase strand transfer inhibitor

Answer 29

Raltegravir

Question 30

HAART A

Answer 30

AZT / zidovudine | D4T / Stavudine

Question 31

HAART B

Answer 31

``` Didanosine Zalcitabine Lamivudine Emtricitabine Abacavir ```

Question 32

HAART C

Answer 32

A PI - ritonavir indinavir | Nnrti - nevirapine delavirdine

Question 33

Anti hepa B and their analogs

Answer 33

``` LATTE-CATAG Lamivudine Adefovir Telbivudine Tenofovir Entecavir ```

Question 34

For hep c and RSV (?)

Answer 34

Ribavirin

Question 35

Amantidine rimantidine moa

Answer 35

Anti influenza - blocks the m2 proton ion channel of the virus oarticke - INHIBIT UNCOATING

Question 36

Neuraminidase inhibitors - preventing RELEASE

Answer 36

Zanavir | Oseltamavir

Question 37

Oseltamavir vs zanamivir

Answer 37

Oseltamavir ORAL | zanavir INHALATIONAL