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Pharma > PHARMA anti Virals > Flashcards

PHARMA anti Virals Flashcards

0
Q

Blocker of penetration

A

Interferon alpha

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1
Q

Blockers of viral attachment and entry

A 
ENMADOPA
Enfuviritide
Maraviroc
Doconasol 
Palivizuma
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2
Q

Blocks uncoating

A

Amantidine
Rimantidine
(Anti influenzas)

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3
Q

Blockers of nuckeid acid synthesis

A

NRTIs
NNRTIs
Acyclovir
Foscarnet

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4
Q

Blockers of late protein synthesis and processing

A

Protease inhibitors
Ritonavir
Indinavir

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5
Q

Blocker of viral release

A

Neuraminidase inhibitors
Zanavidir
Oselnativir ??

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6
Q

Monophosphorylated by thymidine kinase

A

Acyclovir
Valacyclovir
Famciclovir

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7
Q

Acyclovir moa

A

Competitive inhibition of viral dna polymerase

Chain termination

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8
Q

L valyl ester ofadcyclovir with higher bioavailability

A

Valacyclovir

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9
Q

Prodrug of penciclovir that DOES NOT cause chain termination

A

Famciclovir

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10
Q

Topical cream that prevents viral entry

A

Doconasol

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11
Q

Phosphorykated intracellularly by HOST ENZYMES, competes with thymidine triphosphate

A

Trifluridine

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12
Q

Trifluridine use

A

Keratoconjunctivitis

Keratitis

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13
Q

Three anti cmv agents

A

Ganciclovir
Foscarnet
Cidofovir

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14
Q

Phosphorylated by viral PHOSPHOTRANSRASE, fir cmv inducing retinitis

A

Ganciclovir

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15
Q

Not an antimetabolite, blocks pyrophosphate binding sites of enzymes

A

Foscarnet

16
Q

With activity against tk- strains

A

Trifluridine
Foscarnet
Cidofovir

17
Q

Cytosine nucleotide analog, potent inhibitor and substrate for viral dna polymerase

A

Cidofovir

18
Q

Structural analogs that cause COMPETITIVE inhibition of hiv 1 reverse transcriptase

A

NRTIs

19
Q

5 examples of NRTIs

A 
Zidovudine - prototype
Didanosine - pancreatitis
Zalcitabine - neutropenia
Stavudine - myelosuppression less than azt
Lamivudine - for hepa B
20
Q

Binds directly to reverse transcriptase in an ALLOSTERIC MANNER

A

NNRTIs

21
Q

2 examples of nnrtis

A

Delavirdine

Nevirapine

22
Q

Protease inhibitors

A

Ritonavir

Indinavir

23
Q

PI that increases effect of dronabinol

A

Ritonavir

24
Q

PI with lesssdideedffects

A

Indinavir

25
Q

Protease inhibitor side effect

A

Fat redistribution

26
Q

Entry inhibitors / fusion inhibitors

A

Enfuvirtide

Maraviroc

27
Q

Binds to gp41 subunit of envelope glycoprotein, can be given SQ

A

Enfuviritide

28
Q

CCR5 Receptor antagonist, tropism testing needed

A

Maraviroc

29
Q

Integrase strand transfer inhibitor

A

Raltegravir

30
Q

HAART A

A

AZT / zidovudine

D4T / Stavudine

31
Q

HAART B

A 
Didanosine
Zalcitabine
Lamivudine
Emtricitabine
Abacavir
32
Q

HAART C

A

A PI - ritonavir indinavir

Nnrti - nevirapine delavirdine

33
Q

Anti hepa B and their analogs

A 
LATTE-CATAG
Lamivudine
Adefovir
Telbivudine
Tenofovir
Entecavir
34
Q

For hep c and RSV (?)

A

Ribavirin

35
Q

Amantidine rimantidine moa

A

Anti influenza - blocks the m2 proton ion channel of the virus oarticke - INHIBIT UNCOATING

36
Q

Neuraminidase inhibitors - preventing RELEASE

A

Zanavir

Oseltamavir

37
Q

Oseltamavir vs zanamivir

A

Oseltamavir ORAL

zanavir INHALATIONAL

Pharma (20 decks)

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