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Pharma > PHARMA antidepressants > Flashcards

PHARMA antidepressants Flashcards

1
Q

Main classes of antidepressants

A

A Selective Serotonin Reuptake Inhibitor (SSRIs); B Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs); C Tricyclics (TCAs) (pramines & -tryptylines); D 5-HT2 Antagonists (-zodones); E Tetracyclics/Unicyclics; F Monoamine Inhibitors (MAOIs)

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2
Q

1 Citalopram

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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3
Q

2 Escitalopram

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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4
Q

3 Fluoxentine*

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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5
Q

4 Fluvoxamine

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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6
Q

5 Paroxentine

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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7
Q

6 Sertraline

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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8
Q

7 Vilazodone

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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9
Q

MOA of SSRIs

A

Selective blockage of SERT, little effect in NET and beta adrenergic receptors

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10
Q

SSRI with longest half life

A

Fluoxentine

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11
Q

SSRI with highest bioavailability

A

FluVoxamine (bioaVailability)

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12
Q

SSRI with highest volume of distribution

A

Paroxentine

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13
Q

SSRI na potent inhibitor of CYP206, with higest drug interactions

A

FluvoXamine & ParoXentine (with X = enzyme inhibitor)

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14
Q

SSRI that causes weight GAIN and cardial septal defect

A

Paroxentine

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15
Q

SSRI that causes dizziness and paresthesias

A

Sertraline and Paroxentine

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16
Q

SSRI adverse effect related to reproduction

A

sexual dysfunction

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17
Q

SSRI that significantly improves anxiety symptoms

A

Citalopram

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18
Q

Most potent SSRI

A

Escitalopram

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19
Q

SSRI that causes weight LOSS

A

Fluoxentine

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20
Q

Clinical use of Fluvoxamine (SSRI)

A

used in OCD and panic disoders

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21
Q

Clinical use of Paroxentine (SSRI)

A

anticholinergic function; sedating

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22
Q

SSRI na taken with food to increase absorption, causes nausea

A

Sertraline

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23
Q

1 Duloxetine* class

A

B Serotonin-Norepinephrine Reuptake inhibitors (SnRIs)

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24
Q

2 Milnacipran class

A

B Serotonin-Norepinephrine Reuptake inhibitors (SnRIs)

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25
Q

3 Venlafaxine class

A

B Serotonin-Norepinephrine Reuptake inhibitors (SnRIs)

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26
Q

4 Desvenlafaxine class

A

B Serotonin-Norepinephrine Reuptake inhibitors (SnRIs)

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27
Q

MOA of SNRIs

A

moderate selective blockade of SERT and NET

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28
Q

Half life of Venlaxagine and Desvenlaxagine (SNRIs)

A

11-12 hours, short half life but dosing is still OD

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29
Q

SNRI shortest t1/2 & highest bioavailability

A

Milnacipran

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30
Q

SNRI na highest volume of distribution & most protein-bound; once daily dosing

A

Duloxetine

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31
Q

SNRI na lowest protein binding

A

Venlafaxine and Desvenlafaxine

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32
Q

SNRI na conugated

A

Desvenlafaxine

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33
Q

Most common adverse effects of SNRI

A

Anticholinergic like dry mouth, constipation, urinary retention, blurred vision, confusion

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34
Q

SNRI that causes cardiac toxicity

A

Venlafaxine

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35
Q

SNRI that causes hepato toxicity

A

Duloxentine

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36
Q

Contraindication of SNRI

A

MAOIs

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37
Q

SNRI that elevates TCA levels

A

Duloxentine

38
Q

Clinical use of Duloxentine (SNRI)

A

Urinary stress incontinence

39
Q

Clinical use of Venlafaxine and Desvenlafaxine

A

Vasomotor symptoms of menopause

40
Q

1 Imipramine*

A

C Tricyclic

41
Q

2 Clomipramine*

A

C Tricyclic

42
Q

3 Desipramine

A

C Tricyclic

43
Q

4 Trimipramine

A

C Tricyclic

44
Q

5 Amitryptyline

A

C Tricyclic

45
Q

6 Nortriptyline

A

C Tricyclic

46
Q

7 Protryptyline

A

C Tricyclic

47
Q

8 Doxepin

A

C Tricyclic

48
Q

MOA of tricyclics

A

same with SNRI but less adverse effects

49
Q

Tricyclics have long half lives Pero sino yung shortest half life sakanila?

A

Imipramine (imi mini miney moe Shortie hahaha)

50
Q

TCA with shortest t1/2 but highest volume of distribution

A

Imipramine

51
Q

TCA with no active metabolites but with wide therapeutic window

A

Desipramine and Nortryptyline

52
Q

alpha blocking effect of anti depressants causes what

A

Orthostatic hypotension

53
Q

h1 antagonism effect of anti depressants causes what

A

Weight gain and sedation

54
Q

TCA with sexual effects

A

Clomipramine

55
Q

TCA that causes weight gain and sedation

A

Doxepine

56
Q

1 Nefazodone

A

D 5 HT 2 Antagonists

57
Q

2 Trazodone

A

D 5 HT 2 Antagonists

58
Q

Nefazodone and Trazodone MOA

A

Inhibition of 5-HT2A receptor

59
Q

5HT2 antagonist that causes sedation

A

Trazodone

60
Q

5HT2 antagonist that causes hepatotoxicity

A

Nefazodone

61
Q

5HT2 antagonist that causes PRIAPISM

A

Trazodone

62
Q

1 Bupropion

A

E Tetracyclics / Unicyclics

63
Q

2 Amoxapine

A

E Tetracyclics / Unicyclics

64
Q

3 Maprotiline

A

E Tetracyclics / Unicyclics

65
Q

4 Mirtazapine

A

E Tetracyclics / Unicyclics

66
Q

Tetracyclic with biphasic elimination

A

Bupropion

67
Q

Tetracyclic with shortest half life

A

Amoxapine

68
Q

Amoxapine adverse effect (tetracyclic)

A

Parkinsonian syndrome

69
Q

Mirtazapine adverse effect (tetracyclic)

A

Sedation

70
Q

TCA-like tetracyclics

A

Maprotiline and Amoxapine

71
Q

1 Isocarboxazid

A

F MAO inhibitor

72
Q

2 Phenelzine

A

F MAO inhibitor

73
Q

3 Tranylcypromine

A

F MAO inhibitor

74
Q

4 Selegiline

A

F MAO inhibitor

75
Q

5 Moclobemide

A

F MAO inhibitor

76
Q

MAOIs most common adverse effect

A

hypotension & weight gain

77
Q

MAOIs drug interaction

A

Serotonergic agents - causing SEROTONIN SYNDROME

78
Q

Indication for use of Antidepresants

A

Major depression

79
Q

What to use for post traumatic stress disorder

A

SSRIs

80
Q

What to use for OC DISORDER

A

SSRIs

81
Q

What to use for SOCIAL ANXIETY DISORDER

A

SSRIs, Venlafaxine

82
Q

What to use for PAIN DISORDER

A

TCAs, Duloxetine, Milnacipran

83
Q

What to use for PRE MENSTRUAL DYSPHORIC DISORDER

A

Fluoxetine, Sertraline

84
Q

What to use for SMOKING CESSATION

A

Bupropion

85
Q

What to use for BULIMIA

A

Fluoxetine, Bupropion (weight loss)

86
Q

What to use for URINARY STRESS INCONTINENCE

A

Duloxetine

87
Q

What to use for PERIMENOPAUSAL EFFECTS

A

Desvenlafaxine, Venlafaxine, Nefazodone

88
Q

What to use for PREMATURE EJACULATION

A

SSRIs

89
Q

Order of choice of antidepressants

A

SSRIs then SNRIs then Bupropion then Mirtazapine

90
Q

Order of choice of antidepressants with least association with side effects

A

Bupropion then Mirtazapine then Nefazodone

Pharma (20 decks)

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