PHARMA antidepressants Flashcards by aura a

Q

Main classes of antidepressants

A

A Selective Serotonin Reuptake Inhibitor (SSRIs); B Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs); C Tricyclics (TCAs) (pramines & -tryptylines); D 5-HT2 Antagonists (-zodones); E Tetracyclics/Unicyclics; F Monoamine Inhibitors (MAOIs)

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Q

1 Citalopram

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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Q

2 Escitalopram

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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Q

3 Fluoxentine*

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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Q

4 Fluvoxamine

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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Q

5 Paroxentine

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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Q

6 Sertraline

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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Q

7 Vilazodone

A

A SELECTIVE Serotonin Reuptake inhibitors (SSRIs)

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Q

MOA of SSRIs

A

Selective blockage of SERT, little effect in NET and beta adrenergic receptors

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Q

SSRI with longest half life

A

Fluoxentine

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Q

SSRI with highest bioavailability

A

FluVoxamine (bioaVailability)

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Q

SSRI with highest volume of distribution

A

Paroxentine

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Q

SSRI na potent inhibitor of CYP206, with higest drug interactions

A

FluvoXamine & ParoXentine (with X = enzyme inhibitor)

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Q

SSRI that causes weight GAIN and cardial septal defect

A

Paroxentine

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Q

SSRI that causes dizziness and paresthesias

A

Sertraline and Paroxentine

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Q

SSRI adverse effect related to reproduction

A

sexual dysfunction

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Q

SSRI that significantly improves anxiety symptoms

A

Citalopram

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Q

Most potent SSRI

A

Escitalopram

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Q

SSRI that causes weight LOSS

A

Fluoxentine

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Q

Clinical use of Fluvoxamine (SSRI)

A

used in OCD and panic disoders

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Q

Clinical use of Paroxentine (SSRI)

A

anticholinergic function; sedating

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Q

SSRI na taken with food to increase absorption, causes nausea

A

Sertraline

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Q

1 Duloxetine* class

A

B Serotonin-Norepinephrine Reuptake inhibitors (SnRIs)

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Q

2 Milnacipran class

A

B Serotonin-Norepinephrine Reuptake inhibitors (SnRIs)

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Q

3 Venlafaxine class

A

B Serotonin-Norepinephrine Reuptake inhibitors (SnRIs)

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Q

4 Desvenlafaxine class

A

B Serotonin-Norepinephrine Reuptake inhibitors (SnRIs)

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Q

MOA of SNRIs

A

moderate selective blockade of SERT and NET

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Q

Half life of Venlaxagine and Desvenlaxagine (SNRIs)

A

11-12 hours, short half life but dosing is still OD

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Q

SNRI shortest t1/2 & highest bioavailability

A

Milnacipran

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Q

SNRI na highest volume of distribution & most protein-bound; once daily dosing

A

Duloxetine

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Q

SNRI na lowest protein binding

A

Venlafaxine and Desvenlafaxine

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Q

SNRI na conugated

A

Desvenlafaxine

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Q

Most common adverse effects of SNRI

A

Anticholinergic like dry mouth, constipation, urinary retention, blurred vision, confusion

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Q

SNRI that causes cardiac toxicity

A

Venlafaxine

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Q

SNRI that causes hepato toxicity

A

Duloxentine

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Q

Contraindication of SNRI

A

MAOIs

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Q

SNRI that elevates TCA levels

A

Duloxentine

Q

Clinical use of Duloxentine (SNRI)

A

Urinary stress incontinence

Q

Clinical use of Venlafaxine and Desvenlafaxine

A

Vasomotor symptoms of menopause

Q

1 Imipramine*

A

C Tricyclic

Q

2 Clomipramine*

A

C Tricyclic

Q

3 Desipramine

A

C Tricyclic

Q

4 Trimipramine

A

C Tricyclic

Q

5 Amitryptyline

A

C Tricyclic

Q

6 Nortriptyline

A

C Tricyclic

Q

7 Protryptyline

A

C Tricyclic

Q

8 Doxepin

A

C Tricyclic

Q

MOA of tricyclics

A

same with SNRI but less adverse effects

Q

Tricyclics have long half lives Pero sino yung shortest half life sakanila?

A

Imipramine (imi mini miney moe Shortie hahaha)

Q

TCA with shortest t1/2 but highest volume of distribution

A

Imipramine

Q

TCA with no active metabolites but with wide therapeutic window

A

Desipramine and Nortryptyline

Q

alpha blocking effect of anti depressants causes what

A

Orthostatic hypotension

Q

h1 antagonism effect of anti depressants causes what

A

Weight gain and sedation

Q

TCA with sexual effects

A

Clomipramine

Q

TCA that causes weight gain and sedation

A

Doxepine

Q

1 Nefazodone

A

D 5 HT 2 Antagonists

Q

2 Trazodone

A

D 5 HT 2 Antagonists

Q

Nefazodone and Trazodone MOA

A

Inhibition of 5-HT2A receptor

Q

5HT2 antagonist that causes sedation

A

Trazodone

Q

5HT2 antagonist that causes hepatotoxicity

A

Nefazodone

Q

5HT2 antagonist that causes PRIAPISM

A

Trazodone

Q

1 Bupropion

A

E Tetracyclics / Unicyclics

Q

2 Amoxapine

A

E Tetracyclics / Unicyclics

Q

3 Maprotiline

A

E Tetracyclics / Unicyclics

Q

4 Mirtazapine

A

E Tetracyclics / Unicyclics

Q

Tetracyclic with biphasic elimination

A

Bupropion

Q

Tetracyclic with shortest half life

A

Amoxapine

Q

Amoxapine adverse effect (tetracyclic)

A

Parkinsonian syndrome

Q

Mirtazapine adverse effect (tetracyclic)

A

Sedation

Q

TCA-like tetracyclics

A

Maprotiline and Amoxapine

Q

1 Isocarboxazid

A

F MAO inhibitor

Q

2 Phenelzine

A

F MAO inhibitor

Q

3 Tranylcypromine

A

F MAO inhibitor

Q

4 Selegiline

A

F MAO inhibitor

Q

5 Moclobemide

A

F MAO inhibitor

Q

MAOIs most common adverse effect

A

hypotension & weight gain

Q

MAOIs drug interaction

A

Serotonergic agents - causing SEROTONIN SYNDROME

Q

Indication for use of Antidepresants

A

Major depression

Q

What to use for post traumatic stress disorder

A

SSRIs

Q

What to use for OC DISORDER

A

SSRIs

Q

What to use for SOCIAL ANXIETY DISORDER

A

SSRIs, Venlafaxine

Q

What to use for PAIN DISORDER

A

TCAs, Duloxetine, Milnacipran

Q

What to use for PRE MENSTRUAL DYSPHORIC DISORDER

A

Fluoxetine, Sertraline

Q

What to use for SMOKING CESSATION

A

Bupropion

Q

What to use for BULIMIA

A

Fluoxetine, Bupropion (weight loss)

Q

What to use for URINARY STRESS INCONTINENCE

A

Duloxetine

Q

What to use for PERIMENOPAUSAL EFFECTS

A

Desvenlafaxine, Venlafaxine, Nefazodone

Q

What to use for PREMATURE EJACULATION

A

SSRIs

Q

Order of choice of antidepressants

A

SSRIs then SNRIs then Bupropion then Mirtazapine

Q

Order of choice of antidepressants with least association with side effects

A

Bupropion then Mirtazapine then Nefazodone