Pharm Final Flashcards
Thiazide depletes
potassium (fatigue)
What antihyperlipidemia drug is water soluble and inhibits lipolysis in adipose tissue
niacin (decr liver triglycerides and lower VLDL and LDL)
Skin flush
Pruritis
Nausea
Ab pain
side effects of Niacin
stimualtes lipoprotein lipase to breakdown triglycerides into FFA’s and remove from plasma
clofibrate (don’t use with anticoagulant)
Condition where clofibrate is used
hypertryglyceridemia
Myositis
Gi disturbance
gall stones
side effects of clofibrate
Binds to bile acid and bile salt in SI and excreted in feces
Cholestyramine
MC HMG-CoA reductase inhibitors
lovastatin/mevacor
Misvastatin/zocor
myopathy
rhabdomyolysis
abnormal liver function
side effects of lovastatin and zocor
pregnant and nursing mothers should not take which antihyperlipidemias
lovastatin and zocor
prostaglandin synthesis:
phospholipid to arachidonic acid (via cyclooxyrgenase) to prostaglandin
prostaglandins stimulate TXA2 for
platelet aggregation
aspirin acts as anti-inflammatory by
decr prostaglandin synthesis by inhibiting cyclooxygenase
high dose of aspirin can lead to
hyperventilation and respiratory alkalosis
do all NSAIDs cause interstitial nephritis?
No. not aspirin
Hepatitis w/ cerebreal edema is caused by chicken pox and aspirin: name syndrome
reyes syndrome
when is aspirin prescribed
1 antipyretic
- analgesic/antiinflammatory
- unstable angina
- coronary artery thrombosis
if patient bleeds in GIT due to aspirin use, they should be given
misoprostol/cytotec
aspirin side effects
nausea vomiting gastritis prolonged bleeding allergy metabolic acidosis reyes syndrome
lethal dose of aspirin
> 13 grams
NSAID’s that work as anti-inflammatory, analgesic, antipyretic and better than aspirin–work as potent cyclooxyrgenase inhibitors
- ibuprofen/motrin (fever)
2. naproxen/anaprox
Ibuprofen side effects
GI bleed
prolonged bleeding
*interstitial nephritis
Indomethacin is prescribed for
RA, AS, Gout
indomethacin side effects
GI bleed
*frontal HA
neutopenia
thrombocytopenia
