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Aaron-Exit: Championship Rounds > Pharm basics > Flashcards

Pharm basics Flashcards

1
Q

what order of elimination is this?

What drugs are limited this way?

A

Zero order elimination

Phenytoin, Ethanol, and Aspirin

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2
Q

What drugs are eliminated this way?

What order is this?

A

many drugs

First order

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3
Q

When discussing drug interactions:

Effect of substance A and B together is equal to the sum of their individual effects

A

Additive

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4
Q

When discussing drug interactions:

What is presence of substance A is required for the full effects of substance B?

A

Permissive

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5
Q

When discussing drug interactions:

What is the effect of substance A and B is greater together than the sum of their individual effects

A

synergistic

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6
Q

What is the acute decrease in response to a drug after initial/repeated administration?

A

Tachyphylatic

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7
Q

Volume of distribution is low

What comparment is my drug usually located in?

What is the drug type?

A

Intravascular

Large/charged molecules; plasma protein bound

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8
Q

When the volume of distribution is medium

What compartment is it in?

What is the drug type?

A

ECF

Small hydrophilic molecules

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9
Q

What is the large volume of distribution

What compartment is it usually?

What is the drug type?

A

All tissues regarding fat

Small lipophilic molecules

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10
Q

When there is renal or liver disease what happens to the mainteance dose and the loading dose?

A

Maintenance dose is lower

Loading dose is unchanged

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11
Q

Time to steady state depends primarily on what?

A

half life

Independent of dose and

dosing frequency

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12
Q

Reduction

Oxidation

Hydrolysis

These three things occur with cytochrome P-450

What phase is this?

A

Phase 1

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13
Q

What phase are we in now?

Conjugation which is

Methylation

Glucuronidation

Acetylation

Sulfation

A

Phase II of drug metabolism

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14
Q

What is an indirect agonist: anticholinesterase that doesnt cross the BBB?

Is this a polar or nonpolar drug?

A

Neostigmine

Polar

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15
Q

What is the indirect agonist that crosses the blood brain barrier freely?

Is this a polar or non polar drug?

A

Physostigmine

Non-polar

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16
Q

What drug is an indirect agonist, anticholinesterase, that is used for myasthenia gravis?

Does it penetrate the CNS?

A

Pyridostigmine

No

17
Q

When D1 is stimulated, what is the MOA, via the G(s) pathway?

A

Relaxes renal vascular smooth muscle

18
Q

When there is D2 agonist, G(i), what is the MOA, non psych stuff?

A

Modulates transmitter release, especially in brain

19
Q

What is the ending for -ximab mean?

A

Chimeric human-mouse monoclonal Ab

20
Q

What does the ending of -zumab, stand for?

A

Humanized mouse monoclonal antibody

21
Q

What does the suffix -umab stand for?

A

Human monoclonal Antibody

22
Q

What does the ending -tinib inhibit?

A

tyrosine kinase inhibitor

23
Q

What does -zomib inhibit?

A

Proteasome inhibitor

24
Q

What does the -ciclib inhibit?

A

cyclin-dependent kinase inhibitor

25
Q

What does the ending of -cept stand for?

A

TNF-alpha antagonist

26
Q

What does the ending -leukin stand for or go after?

A

IL-2 agonist/analog

27
Q

What does the ending of -kinra stand for work on?

A

Interluekin receptor antagonist

28
Q

In the world of Hep C drugs:

What inhibits NS5A, a viral phosphoprotein that plays a key role in RNA replication?

A

Ledipasvir and Ombitasvir “North Sea in Sketchy”

29
Q

In the world of Hep C:

What inhibits NS5B, and RNA dependent RNA polymerase acting as a chain terminator?

A

Sofosbuvir and Dasabuvir

THis is the sofa couch in sketchy

30
Q

What inhibits NS3/4A a viral protease preventing viral replication?

A

Grazoprevir and Simeprevir

This is the “stuck machette” in sketchy

31
Q

What is/are the side effects of

Grazoprevir

Simeprevir

?

A

Grazoprevir: Photosensitivity reactions (camera)

Simeprevir: Headache and Fatigue

Aaron-Exit: Championship Rounds (27 decks)

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