Odd Stuff 2

Question 1

Error of morphogenesis: Secondary breakdown of previously normal tissue or structure (amniotic band syndrome)

Answer 1

Disruption

Question 2

Error of morphogenesis: Extrinsic disruption, multiple gestation, crowding, foot deformities, occurs after embryonic period

Answer 2

Deformation

Question 3

Error of morphogenesis Intrinsic disruption; occurs during embryonic period (weeks 3-8)

Answer 3

Malformation

Question 4

Error of morphogenesis: Abnormalities result from a single primary embryologic event, i.e. Potter

Answer 4

Sequence

Question 5

What do integrins bind too?

Answer 5

bind to fibronectin and laminin

Question 6

In the world of antibiotics: What inhibits binding of the 50S subunit, prevents formation of the initiation complex? Am I bacteriostatic or bactericidal?

Answer 6

Linezolid Variable (first aid)

Question 7

In the world of antibiotics: What causes the irreversible inhibition of initiation complex through binding of the 30S subunit, causes misreading of mRNA, blocks translocation? Am I bacteriostatic or bactericidal?

Answer 7

Aminoglycoside Bacteriocidal No anaerobic coverage here

Question 8

In the world of antibiotics: What binds to 30S and prevents attachment of aminoacyl-tRNA; limited CNS penetration? Am I bacteriostatic or bactericidal?

Answer 8

Tetracyclines, causes misreading of the mRNA Bacteriostatic

Question 9

In the world of antibiotics: What binds to the 30S, inhibits protein synthesis? Am I bacteriostatic or bactericidal?

Answer 9

Glycylcyclines

This is a derivative of tetracycline with a different MOA

Bacteriostatic

Question 10

In the world of antibiotics: What blocks peptidyltransferase at 50S ribosomal subunit? Am I bacteriostatic or bactericidal?

Answer 10

Chloramphenicol Bacteriostatic Look out for Gray baby

Question 11

In the world of antibiotics: What blocks peptide transfer (translocation) at 50S ribosomal subunit? Am I bacteriostatic of bactericidal?

Answer 11

Clindamycin Bacteriostatic Anaerobic coverage

Question 12

In the world of antibiotics: What inhibits protein synthesis by blocking translocation; binds to the 23S rRNA of the 50S ribosomal subunit? Am I bacteriostatic of bactericidal?

Answer 12

Macrolides Bacteriostatic

Question 13

Vasculitus: when we are a small vessel vasculitis, and come back positive for HLA-51, what two diseases could they be?

Answer 13

HSV or Parvovirus Behcet Syndrome

Question 14

What vasculitus shows up with heavy smokers?

Answer 14

Buerger Disease (Thromboangiitis)

Question 15

CYP-1A2 breaks down what?

Answer 15

Acetaminophen

Question 16

What does the CYP 2E1 break down?

Answer 16

Ethanol

Question 17

What does CYP 2C9 break down?

Answer 17

Warfarin/Coumadin

Question 18

What does the CYP 2D6 break down?

Answer 18

Cardio Drugs

Question 19

What does the CYP 3A4 break down?

Answer 19

Most Common

Question 20

Rheumatoid Nodules + Pneumoconiosis is what?

Answer 20

Caplan Syndrome

Question 21

Rheumatoid Nodules

Neutropenia

Splenomegaly

What is this?

Answer 21

Felty Syndrome

Question 22

Epithelial Cells cause what kind of cancer?

What does it stain for?

Answer 22

Squamous Cell Carcinoma

Cytokeratin

Question 23

What does mesenchymal tissue stain for?

What kind of cancer does it stain positive for?

Answer 23

Vimentin (fibroblasts, endothelial cells, macrophages)

Sarcoma, mostly

Question 24

Sarcoma stains positive mostly for sarcomas, what are the other three things it stains positive for?

Answer 24

RCC

Meningoma

Endometrial Carcinoma

Question 25

What does Bloom Syndrome have that is defective?

Answer 25

DNA helicase

Question 26

What CYP enzyme breaks down omperazole, diazepam, citaolpram, clopidogrel?

Answer 26

CYP-2C19

Question 27

What disease is HLA A3?

Answer 27

Hemochromatosis

Question 28

What disease HLA-B8 only?

Answer 28

Myasthenia Gravis

Question 29

What HLA is for Psoriatic arthritis, Ankylosing Spondylitis, IBD-associated arthritis, Reactive Arthritis?

Answer 29

HLA-B27

Question 30

What HLA is Psoriasis?

Answer 30

HLA-C

Question 31

What disease is HLA DQ2/ DQ8?

Answer 31

Celiac Disease

Question 32

What HLA is for Multiple Sclerosis, Hay Fever, Goodpasture Syndrome?

Answer 32

HLA-DR2

Question 33

What HLA is Rheumatoid Arthritis?

Answer 33

HLA-DR4

Question 34

What disease is HLA B8 and HLA DR3?

Answer 34

Graves Disease

Question 35

What disease is HLA DR2 and DR3?

Answer 35

SLE

Question 36

What disease is HLA B8, DR3, DR4?

Answer 36

Addison Disease

Question 37

What disease is DR3 and DR5?

Answer 37

Hashimoto Thyroiditis

Question 38

What HLA is DM type 1?

Answer 38

DR3 and DR4

Question 39

What are TLR 1 and 2, who do they belong too?

Answer 39

All bacteria Bacterial Lipoproteins

Question 40

What are TLR 2 and 6, who do they belong too?

Answer 40

Lipoteichoic acid Gram positive bacteria

Question 41

What are TLR 2 and 6, assuming they belong to Mannose-conjugated proteins?

Answer 41

All fungi

Question 42

Who has TLR 4, belong too and do?

Answer 42

Gram negative bacteria, Lipid A

Question 43

What do TLR 5 show up with, and who?

Answer 43

All bacteria, with flagella

Question 44

TLR 3, what/who does it show up with?

Answer 44

TLR3, viruses with RNA genomes, double stranded RNA

Question 45

What does TLR 7 and 8 show up with, who?

Answer 45

Endosomal RNA, viruses with RNA genomes

Question 46

What does TLR 9, show up with and who?

Answer 46

Bacteria and Viruses, unmethylated CpG motifs in DNA