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Aaron-Exit: Championship Rounds > Odd Stuff 2 > Flashcards

Odd Stuff 2 Flashcards

1
Q

Error of morphogenesis: Secondary breakdown of previously normal tissue or structure (amniotic band syndrome)

A

Disruption

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2
Q

Error of morphogenesis: Extrinsic disruption, multiple gestation, crowding, foot deformities, occurs after embryonic period

A

Deformation

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3
Q

Error of morphogenesis Intrinsic disruption; occurs during embryonic period (weeks 3-8)

A

Malformation

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4
Q

Error of morphogenesis: Abnormalities result from a single primary embryologic event, i.e. Potter

A

Sequence

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5
Q

What do integrins bind too?

A

bind to fibronectin and laminin

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6
Q

In the world of antibiotics: What inhibits binding of the 50S subunit, prevents formation of the initiation complex? Am I bacteriostatic or bactericidal?

A

Linezolid Variable (first aid)

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7
Q

In the world of antibiotics: What causes the irreversible inhibition of initiation complex through binding of the 30S subunit, causes misreading of mRNA, blocks translocation? Am I bacteriostatic or bactericidal?

A

Aminoglycoside Bacteriocidal No anaerobic coverage here

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8
Q

In the world of antibiotics: What binds to 30S and prevents attachment of aminoacyl-tRNA; limited CNS penetration? Am I bacteriostatic or bactericidal?

A

Tetracyclines, causes misreading of the mRNA Bacteriostatic

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9
Q

In the world of antibiotics: What binds to the 30S, inhibits protein synthesis? Am I bacteriostatic or bactericidal?

A

Glycylcyclines

This is a derivative of tetracycline with a different MOA

Bacteriostatic

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10
Q

In the world of antibiotics: What blocks peptidyltransferase at 50S ribosomal subunit? Am I bacteriostatic or bactericidal?

A

Chloramphenicol Bacteriostatic Look out for Gray baby

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11
Q

In the world of antibiotics: What blocks peptide transfer (translocation) at 50S ribosomal subunit? Am I bacteriostatic of bactericidal?

A

Clindamycin Bacteriostatic Anaerobic coverage

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12
Q

In the world of antibiotics: What inhibits protein synthesis by blocking translocation; binds to the 23S rRNA of the 50S ribosomal subunit? Am I bacteriostatic of bactericidal?

A

Macrolides Bacteriostatic

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13
Q

Vasculitus: when we are a small vessel vasculitis, and come back positive for HLA-51, what two diseases could they be?

A

HSV or Parvovirus Behcet Syndrome

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14
Q

What vasculitus shows up with heavy smokers?

A

Buerger Disease (Thromboangiitis)

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15
Q

CYP-1A2 breaks down what?

A

Acetaminophen

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16
Q

What does the CYP 2E1 break down?

A

Ethanol

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17
Q

What does CYP 2C9 break down?

A

Warfarin/Coumadin

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18
Q

What does the CYP 2D6 break down?

A

Cardio Drugs

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19
Q

What does the CYP 3A4 break down?

A

Most Common

20
Q

Rheumatoid Nodules + Pneumoconiosis is what?

A

Caplan Syndrome

21
Q

Rheumatoid Nodules

Neutropenia

Splenomegaly

What is this?

A

Felty Syndrome

22
Q

Epithelial Cells cause what kind of cancer?

What does it stain for?

A

Squamous Cell Carcinoma

Cytokeratin

23
Q

What does mesenchymal tissue stain for?

What kind of cancer does it stain positive for?

A

Vimentin (fibroblasts, endothelial cells, macrophages)

Sarcoma, mostly

24
Q

Sarcoma stains positive mostly for sarcomas, what are the other three things it stains positive for?

A

RCC

Meningoma

Endometrial Carcinoma

25
Q

What does Bloom Syndrome have that is defective?

A

DNA helicase

26
Q

What CYP enzyme breaks down omperazole, diazepam, citaolpram, clopidogrel?

A

CYP-2C19

27
Q

What disease is HLA A3?

A

Hemochromatosis

28
Q

What disease HLA-B8 only?

A

Myasthenia Gravis

29
Q

What HLA is for Psoriatic arthritis, Ankylosing Spondylitis, IBD-associated arthritis, Reactive Arthritis?

A

HLA-B27

30
Q

What HLA is Psoriasis?

A

HLA-C

31
Q

What disease is HLA DQ2/ DQ8?

A

Celiac Disease

32
Q

What HLA is for Multiple Sclerosis, Hay Fever, Goodpasture Syndrome?

A

HLA-DR2

33
Q

What HLA is Rheumatoid Arthritis?

A

HLA-DR4

34
Q

What disease is HLA B8 and HLA DR3?

A

Graves Disease

35
Q

What disease is HLA DR2 and DR3?

A

SLE

36
Q

What disease is HLA B8, DR3, DR4?

A

Addison Disease

37
Q

What disease is DR3 and DR5?

A

Hashimoto Thyroiditis

38
Q

What HLA is DM type 1?

A

DR3 and DR4

39
Q

What are TLR 1 and 2, who do they belong too?

A

All bacteria Bacterial Lipoproteins

40
Q

What are TLR 2 and 6, who do they belong too?

A

Lipoteichoic acid Gram positive bacteria

41
Q

What are TLR 2 and 6, assuming they belong to Mannose-conjugated proteins?

A

All fungi

42
Q

Who has TLR 4, belong too and do?

A

Gram negative bacteria, Lipid A

43
Q

What do TLR 5 show up with, and who?

A

All bacteria, with flagella

44
Q

TLR 3, what/who does it show up with?

A

TLR3, viruses with RNA genomes, double stranded RNA

45
Q

What does TLR 7 and 8 show up with, who?

A

Endosomal RNA, viruses with RNA genomes

46
Q

What does TLR 9, show up with and who?

A

Bacteria and Viruses, unmethylated CpG motifs in DNA

Aaron-Exit: Championship Rounds (27 decks)

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