Odd stuff Flashcards

1
Q

What is the extrinsic pathway mechanism for apoptosis? What is the intrinsic pathway mechanism for apoptosis?

A

caspase 8 caspase 9, cytochrome c

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2
Q

What bundle of joy has the Maltese cross? What are we really similar too, the same tick carries this too?

A

Babesiosis Lyme Disease

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3
Q

What are the two terms: REduce the pathogenic organism counts to a safe level? Inactivate all microbes including spores?

A

Disinfect Sterilize

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4
Q

What type of equipment does the following? Pressurized steam at 120 degrees C, sporicidal, may not reliably inactivate prions

A

Autoclave

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5
Q

What type of equipment does the following? Denature proteins and disrupt cell membranes, not sporicidal Name 2

A

Alcohols and Chlorhexidine

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6
Q

What type of equipment does the following? Oxidizes and denatures proteins, sporicidal

A

Chlorine

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7
Q

What type of equipment does the following? Alkylating agent, sporicidial

A

Ethylene oxide

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8
Q

What type of equipment does the following? Free radical oxidation, sporicidal

A

Hydrogen Peroxide

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9
Q

What type of equipment does the following? Halogenation of DNA and RNA, and proteins, may not be sporicidal

A

Iodine and Iodophors

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10
Q

What type of equipment does the following? Impair permeability of cell membranes, not sporicidal

A

Quaternary Amines

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11
Q

What disease is mixed cryoglobulinemia associated with? Palpable purpura, weakness, arthralgias

A

Hep C

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12
Q

Von Hippel-Lindau disease Renal Cell Carcinoma What is the magic chromosome?

A

Chromosome 3

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13
Q

ADPKD (PKD2), achondroplasia Huntington Disease What is the magic chromosome?

A

Chromosome 4

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14
Q

Cri-du-chat syndrome Familial adenomatous polyposis (FAP) What is the magic chromosome?

A

Chromosome 5

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15
Q

Hemochromatosis (HFE) What is the magic chromosome?

A

Chromosome 6

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16
Q

Friedreich ataxia Tuberous Sclerosis (TSC1) What is the magic chromosome?

A

Chromosome 9

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17
Q

Wilms Tumor B globin defects (sickle cell disease, B-Thalassemia) MEN 1 What is the magic chromosome?

A

Chromosome 11

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18
Q

Patau Syndrome Wilson Disease Retinoblastoma BRCA2 What is the magic chromosome?

A

Chromosome 13

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19
Q

Prader-Willi Syndrome Angelman Syndrome Marfan Syndrome What is the magic chromosome?

A

Chromosome 15

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20
Q

ADPKD (PKD1) Alpha globin gene defects (alpha thalassemia) Tuberous Sclerosis (TSC2) What is the magic chromosome?

A

Chromosome 16

21
Q

Neurofibromatosis type 1 BRCA1 TP53 What is the magic chromosome?

A

Chromosome 17

22
Q

Edwards Syndrome What is the magic chromosome?

A

Chromosome 18

23
Q

Down Syndrome What is the magic chromosome?

A

Chromosome 21

24
Q

Neurofibromatosis Type 2, DiGeorge Syndrome What is the magic chromosome?

A

Chromosome 22

25
Fragile X X-linked agammaglobulinemia Klinefelter Syndrome (XXY) What is the magic chromosome?
Chromosome X
26
Digoxin binds to the Na/K pump What drug binds to the K channels, with the same intention as Digoxin?
Ouabain
27
Williams Syndrome Cystic Fibrosis What is the magic chromosome?
Chromosome 7
28
What is different mutations in the same locus produce the same phenotype?
Allelic Heterogeneity Beta Thalassemia
29
What is the -ximab used for/from? i.e. Rituximab
Chimeric human-mouse monoclonal AB
30
What is the -zumab used for/from? i.e. Bevacizumab
Humanized mouse monoclonal AB
31
What is the -umab used for/from? i.e. Denosumab
Human monoclonal AB
32
What is the -tinib used for/from?
Tyrosine kinase inhibitor
33
What is the -zomib used for/from?
Proteasome inhibitor
34
What is the -ciclib used for/from?
Cyclin-dependent kinase inhibitor
35
What is the -cept ending used for?
TNF-alpha antagonist
36
What is the -leukin used for?
Aldesleukin
37
What is the -kinra used for?
Interleukin receptor Antagonist
38
What does Adalimumab, certolizumab, golimumab, and infliximab go after?
TNF-alpha
39
What does Daclizumab target?
CD25, used in M.S.
40
What does Eculizumab target?
Complement protein C5
41
What does Natalizumab target?
alpha-4- integrin
42
What does Ustekinumab target?
IL-12/IL-23
43
What does Abciximab target?
Platelet glycoproteins IIb/IIIa
44
What does Denosumab target?
RANKL, this is the dinosaur holding the hand crank drill in sketchy
45
What does Omalizumab target?
IgE, this is the limo in the parade anti-inflammatory sketchy
46
What does Palivizumab target?
RSV F Protein
47
What is Erlotinib used for?
EGFR tyrosine Kinase inhibitor, "Geoffery, British Earl" Non small cell lung carcinoma
48
What is cetuximab used for?
antibody against EGFR, colon cancer, tux from the elephant in sketchy
49
What is Imatinib used for?
Tyrosine kinase BCR-ABL, inhibitor, Philly chromosome, CML "broken bell", "Imitation guy in sketchy"