Pharm 9 Cholinergic Pharmacology Flashcards
Degrades synaptobrevin and thus prevents synaptic vesicle fusion with the axon terminal membrane
- Botulinum Toxin
- Produced by C. Botulinum
Inhibit acetylcholinesterase (AChE) by binding to the enzyme’s active site. (5)
- Edrophonium
- Neostigmine
- Pyridostigmine
- Ambenonium
- Physostigmine
Use for Focal Dystonias, Torticollis, Achalasia, Strabismus, Blepharospasm, Pain Syndromes, Wrinkles, and Hyperhidrosis
- Botulinum Toxin (BoTox)
Use for Myasthenia Gravis, Eaton-Lambert Syndrome or other muscles weakness disorders (4)
- Edrophonium
- Neostigmine
- Pyridostigmine
- Ambenonium
Use for Reversal of anticholinergic toxicity or induced surgical paralysis
- Physostigmine
Has direct cholinergic agonist effect at Nm receptors
- Neostigmine
Topical application of (blank, blank) to the cornea of the eye decreases intraocular pressure by facilitating the outflow of aqueous humor
- Cholinesterase Inhibitors
AChE Inhibitor encountered as a toxin, used as an insecticide
- Diisopropyl Fluorophosphate
AChE Inhibitor Used for Alzheimer’s Disease and Dementia
- Tacrine, Donepezil, and Rivastigmine
Stimulate Muscarinic Receptor Activity
- Methacholine
- Carbachol
- Bethanechol
- Cevimeline
- Pilocarpine
Used to Diagnose Asthma
Methacholine
Muscarinic Receptor Agonist Used for Glaucoma
- Carbachol
Muscarinic Receptor Agonist Used for Urinary Tract Motility
- Bethanechol
Muscarinic Receptor Agonists Used for Xerostomia in Sjogren’s Syndrome
- Cevimeline and Pilocarpine
Adverse Effects Include Dyspnea, Lightheadedness, pruritus and throat irritation
- Methacholine
Stimulate opening of nicotinic ACh receptor channel and produce depolarization of the cell membrane (creates a depolarizing blockade)
- Succinylcholine
Used to induce neuromuscular blockade in surgery and for intubation
- Succinylcholine
Adverse Effects Include Muscle Rigidity, myalgia, and raised intraocular pressure
- Succinylcholine
Muscarinic Receptor Antagonist used for Anticholinesterase Overdose, Bradycardia, Premedication for anesthetic, and Antidote to Mushroom Poisoning
- Atropine
Side Effects Include Raised Intraocular pressure, tachycardia, constipation, xerostomia, and blurred vision
- Atropine
Muscarinic Receptor Antagonist used for Motion Sickness, Nausea, and Vomiting delivered via transdermal patch
- Scopolamine
Muscarinic Receptor Antagonist Used for Peptic Ulcer Disease (PUD) and induced bradycardia
- Pirenzepine, Methscopolamine, and Glycopyrrolate
Muscarinic Receptor Antagonist Used for Asthma and COPD
- Ipratropium and Tiotropium
Muscarinic Receptor Antagonist Used for Overactive Bladder and Urge Incontinence
- Oxybutynin, Propantheline, and Terodiline
Nicotinic Receptor Antagonists, prevent endogenous ACh binding and subsequent muscle cell depolarization (nondepolarizing blockade)
- Pancuronium, Tubucurarine, Vecuronium
- Trimethaphan and Mecamylamine
