Pharm 9 Cholinergic Pharmacology

Question 1

Degrades synaptobrevin and thus prevents synaptic vesicle fusion with the axon terminal membrane

Answer 1

• Botulinum Toxin

- Produced by C. Botulinum

Question 2

Inhibit acetylcholinesterase (AChE) by binding to the enzyme’s active site. (5)

Answer 2

• Edrophonium
• Neostigmine
• Pyridostigmine
• Ambenonium
• Physostigmine

Question 3

Use for Focal Dystonias, Torticollis, Achalasia, Strabismus, Blepharospasm, Pain Syndromes, Wrinkles, and Hyperhidrosis

Answer 3

• Botulinum Toxin (BoTox)

Question 4

Use for Myasthenia Gravis, Eaton-Lambert Syndrome or other muscles weakness disorders (4)

Answer 4

• Edrophonium
• Neostigmine
• Pyridostigmine
• Ambenonium

Question 5

Use for Reversal of anticholinergic toxicity or induced surgical paralysis

Answer 5

• Physostigmine

Question 6

Has direct cholinergic agonist effect at Nm receptors

Answer 6

• Neostigmine

Question 7

Topical application of (blank, blank) to the cornea of the eye decreases intraocular pressure by facilitating the outflow of aqueous humor

Answer 7

• Cholinesterase Inhibitors

Question 8

AChE Inhibitor encountered as a toxin, used as an insecticide

Answer 8

• Diisopropyl Fluorophosphate

Question 9

AChE Inhibitor Used for Alzheimer’s Disease and Dementia

Answer 9

• Tacrine, Donepezil, and Rivastigmine

Question 10

Stimulate Muscarinic Receptor Activity

Answer 10

• Methacholine
• Carbachol
• Bethanechol
• Cevimeline
• Pilocarpine

Question 11

Used to Diagnose Asthma

Answer 11

Methacholine

Question 12

Muscarinic Receptor Agonist Used for Glaucoma

Answer 12

• Carbachol

Question 13

Muscarinic Receptor Agonist Used for Urinary Tract Motility

Answer 13

• Bethanechol

Question 14

Muscarinic Receptor Agonists Used for Xerostomia in Sjogren’s Syndrome

Answer 14

• Cevimeline and Pilocarpine

Question 15

Adverse Effects Include Dyspnea, Lightheadedness, pruritus and throat irritation

Answer 15

• Methacholine

Question 16

Stimulate opening of nicotinic ACh receptor channel and produce depolarization of the cell membrane (creates a depolarizing blockade)

Answer 16

• Succinylcholine

Question 17

Used to induce neuromuscular blockade in surgery and for intubation

Answer 17

• Succinylcholine

Question 18

Adverse Effects Include Muscle Rigidity, myalgia, and raised intraocular pressure

Answer 18

• Succinylcholine

Question 19

Muscarinic Receptor Antagonist used for Anticholinesterase Overdose, Bradycardia, Premedication for anesthetic, and Antidote to Mushroom Poisoning

Answer 19

• Atropine

Question 20

Side Effects Include Raised Intraocular pressure, tachycardia, constipation, xerostomia, and blurred vision

Answer 20

• Atropine

Question 21

Muscarinic Receptor Antagonist used for Motion Sickness, Nausea, and Vomiting delivered via transdermal patch

Answer 21

• Scopolamine

Question 22

Muscarinic Receptor Antagonist Used for Peptic Ulcer Disease (PUD) and induced bradycardia

Answer 22

• Pirenzepine, Methscopolamine, and Glycopyrrolate

Question 23

Muscarinic Receptor Antagonist Used for Asthma and COPD

Answer 23

• Ipratropium and Tiotropium

Question 24

Muscarinic Receptor Antagonist Used for Overactive Bladder and Urge Incontinence

Answer 24

• Oxybutynin, Propantheline, and Terodiline

Question 25

Nicotinic Receptor Antagonists, prevent endogenous ACh binding and subsequent muscle cell depolarization (nondepolarizing blockade)

Answer 25

• Pancuronium, Tubucurarine, Vecuronium

- Trimethaphan and Mecamylamine