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Pharmacology LECOM SH > Pharm 43 Histamine > Flashcards

Pharm 43 Histamine Flashcards

1
Q

MOA:

Inverse agonists binding preferntially to inactive conformation of H1 receptors

A

First-Generation H1-Antihistamine

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2
Q

More CNS affect (more lipid soluble)

A

First-Generation H1-Antihistamine

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3
Q

Ethanolamines (1st generation) (4)

A

Diphenhydramine, Carbinoxamine, Clemastine, Dimenhydrinate

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4
Q

Tx:

Allergic rhinitis, insomnia, motion sickness, urticaria, anaphylaxis, parkinsonism

A

First-Generation H1-Antihistamines

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5
Q

Ethylenediamines (1st generation) (2)

A

Pyrilamine, Tripelennamine

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6
Q

Alkylamines (1st generation) (2)

A

Chlorpheniramine, Brompheniramine

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7
Q

Piperidines (1st generation) (2)

A

cyproheptadine, phenidndamine

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8
Q

Phenothiazine (1st generation) (1)

A

Promethazine

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9
Q

Tx:

preoperative anxiety and reduce postoperative nausea and vomiting

A

Promethazine (1st generation)

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10
Q

Piperazines (1st generation) (3)

A

Hydroxyzine, Cyclizine, Meclizine

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11
Q

Tx:

Pruritis, alcohol withdrawal, motion sickness, vertigo

A

Hydroxyzine, cyclizine, meclizine (1st generation)

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12
Q

Tricyclic dibenzoxepins (1st generation) (1)

A

Doxepin

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13
Q

Tx:

Anxiety, Depression, Pruritis

A

Doxepin

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14
Q

Piperizines (2nd generation) (2)

A

Cetirizine, Levocetirizine

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15
Q

Considerations:

less sedating, less anticholinrgic effects

A

2nd generation H1-Antihistamine

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16
Q

Alkylamines (2nd generation) (1)

A

Acrivastine

17
Q

Piperidines (2nd generation) (6)

A

Loratidine, Desloratadine, Levocabastine, Ebastine, Mizolastine, Fexofenadine

18
Q

Phthalazinones (2nd generation) (1)

A

Azelastine

19
Q

Tricyclic dibenzoxepins (2nd generation) (1)

A

Olopatadine

20
Q

H2 Receptor Antagonists (4)

A

Cimetidine, Famotidine, Nizatidine, Ranititdine

21
Q

Tx:

GERD, Peptic Ulcers, Acid Reflux

A

H2 Receptor Antagonist (Cimetidine, Famotidine, Nizatidine, Ranititdine)

22
Q

Consideration:

H2 receptor antagonist with most interactions with other drugs

A

Cimetidine

Pharmacology LECOM SH (24 decks)

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