Ch. 10 Flashcards
inhib. Cat. Synthesis
a-methyltyrosine
phochromocytoma associated HTN
a-methyltyrosine
inhib. Cat. Storage (temp. increase cat in synapse, but long term pool depleted)
reserpine, Guanathedine, Guanadrel, Amphetamine, Methlyphenidate, Pseudoephedrine
HTN (Cat. Storage Inhib)
Reserpine (inhib. VMAT, w/ psychotic depression)
HTN (Cat. Storage Inhib)
Guanathedine,Guanadrel (displace NE in transmitter vesicle)
ADHD,Narcolepsy
Amphetamine, methylphenidate (displace cat., weakly inhibit MAO, block cat from reuptake by NET & DAT)
allergic rhinitis,nasal congestion
Pseudoephedrine
inhib. Cat. Reuptake
Cocaine, imipramine, amitriptyline
MAOI-causing increase in cat, by blocking cat. Degredation
Phenelzine, Iproniazid, Clorgyline, Tranylcypromine, Brofaomine, Moclobemide, Befloxatone, Selegiline (Can cause serotonin syndrome & hypertensive crisis)
a1- agonist -increase periph vasc. Resistance
methoxamine, Phenylephrine, Oxymetazoline, Tetrahydrozoline
hypotension, shock
Methoxamine
opthalmic hyperemia,nasal congestion,hypotension
Phenylephrine, Oxymetazoline, Tetrahydrozoline
a2-agonist- inhbit sympathetics from CNS
Clonidine, Dexmedetomidine, Guanabenz, Guanfacine, Methyldopa
HTN,opoid withdrawal, CA pain,ICU sedation,Preg. HTN
Clonidine, Dexmedetomidine, Guanabenz, Guanfacine, Methyldopa (choice for preg. w/ HTN)
B-agonist -bronchodilation
Metaproterenol, Isoproterenol, Salmeterol, Terbutaline, Albuterol, Dobutamine
a-antagonist -block cat. Causing vasodilation, decr. BP, dec. periph resistance
Phenoxybenzamine, Phentolamine, Prazosin, Terazosin, Doxazosin, Tamsulosin, Yohimbine
phochromocytoma associated HTN ,sweating
Phenoxybenzamine, Phentolamine- alpha 1,2- Used preoperatively
HTN, BPH
Prazosin, Terazosin, Doxazosin- alpha 1- AR: postural Hypotension
BPH
Tamsulosin- alpha 1a (more specific to GU tract)
Organic,psychogenic impotence
Yohimbine- alpha 2a
B-antagonist -block B-receptors
Block B-adronergic receptors
HTN,angina,heart failure,phochromocytoma,Glaucoma
Propranolol, Nadolol, Timolol, Penbutolol, Levobunolol, Carteolol- B1,2 blockers- Propranolol is lipophilic= cross CNS= high sedation
HTN, angina (a1, B1,2 blockers)
Labetalol, Carvedilol- a1, B1,2
HTN, angina (Partial agonist at B1,2)
Pindolol, Acebutolol
HTN, angina,heart failure,Thyroid storm (B1 blocker)
Esmolol (thyroid storm=very short half life), Metoprolol, Atenolol, Betaxolol, Nebivolol