Pharm 14 Serotonergic and Central Adrenergic Neurotransmission

Question 1

Drugs that Interfere with the ability of synaptic vessels to store monamines; displace 5-HT, DA, and NE from their storage vesicles in presynaptic nerve terminals.

Answer 1

• Modafinil, Dextroamphetamine, and Lisdexamfetamine.

Question 2

Drugs that block monoamines by inhibiting the functional flavin moiety of MAO; increase the 5-HT and NE available in the cytoplasm of presynaptic neurons which leads to increased uptake and storage in synaptic vesicles.

Answer 2

• Iproniazid, Phenelzine, and Isocarboxazid (Irreversible, nonselective)
• Moclobemide, Befloxatone, Brofaromine (reversible inhibiters of MAO-A)
• Selegiline (MAO-B inhibitor, also MAO-A at high doses)
• From First Aid (MAO Takes Pride In Shanghai; Tranycypromine, Phenelzine, Isocarboxazid, Selegiline)

Question 3

Drugs that Inhibit reuptake of 5-HT and NE from synaptic cleft by blocking reuptake transporters.

Answer 3

Tricyclic Antidepressants (TCAs)

• Amitriptyline, nortriptyline, Imipramine, Desipramine, Clomipramine, Doxepin, Amoxapine
• All TCAs end in iptyline or ipramine except doxepin and amoxapine.

Question 4

Treats Bedwetting as well as depression.

Answer 4

Imipramine

Question 5

Treats OCD as well as depression

Answer 5

Clomipramine

Question 6

Drugs that Selectively inhibit reuptake of serotonin and cause increased 5-HT receptor activation. At high doses they also bind the NE transporter.

Answer 6

SSRIs

- Fluoxetine, Paroxetine, Sertraline, and Citalopram (Flashbacks Paralyze Senior Citizens)

Question 7

Drugs that block 5-HT reuptake transporter and NE reuptake transporters in a concentration-dependent manner.

Answer 7

SNRIs

- Venlafaxine, Duloxetine, Desvenlafaxine, and Milnacipran

Question 8

Blocks NE transporter, leading to increased NE levels.

Answer 8

Atomoxetine (NRIs)

Question 9

Aminoketone antidepressant that wekaly inhibits neuronal uptake of 5-HT, dopamine, and NE.

Answer 9

Bupropion

Question 10

Blocks 5-HT(2a,2c) and the alpha2-adrenergic autoreceptor and decreases neurotransmission at 5-HT2 synapses while increasing NE neurotransmission.

Answer 10

Mirtazapine

Question 11

Block postsynaptic 5-HT2 receptors

Answer 11

Nefazodone and Trazodone

Question 12

Serotonin 5-HT1a selective agonist

Answer 12

Buspirone

Question 13

Serotonin 5-HT(1d and 1b) agonists

Answer 13

TRIPTANS

- Sumatriptan, Rizatriptan, Almotriptan, Frovatriptan, Eletriptan, and Zolmitriptan.