Pharm 47 Asthma

Question 1

Anticholinergics (2)

Answer 1

Ipratropium, Tiotropium

Question 2

MOA:

Antagonist at muscurinic receptor on airway smooth muscle and glands= decreased bronchoconstriction

Answer 2

Ipratropium, Tiotropium (Anticholinergics)

Question 3

Tx:

Asthma, COPD

Answer 3

Ipratropium, Tiotropium

Question 4

B-Adrenergic Agonists (12)

Answer 4

Epinephrin, Isoproterenol, Isoetharine, Metaproterenol, Terbutaline, Albuterol (Salbutamol), Levalbuteraol, Pirbuterol, Bitolterol, Formoterol, Salmeterol, Arformoterol

Question 5

MOA:

Agonist to B-adrenergic receptors; acts on G protein to relax smooth muscle

Answer 5

B-Adrenergics

Question 6

Tx:

Asthma, Cardiac arrest, shock, heart block, Stokes-Adams syndrome

Answer 6

Isoproterenol

Question 7

Tx:

Anaphylaxis, asthma, open-angle glaucoma, cardiac arrest

Answer 7

Epinephrine

Question 8

Adverse affects:

cardiac arrhythmias, hypertensive crisis, pulmonary edema

Answer 8

Epinephrine

Question 9

MOA:
phosphodiesterase inhibitor preventin degradation of cAMP; also acts on adenosine receptor antagonists= smooth muscle relaxation

Answer 9

Methylxanthines

Question 10

Methylxanthines (2)

Answer 10

Theophylline, Aminophylline

Question 11

Adverse effect:

vent. arrhythmia, sz,

Answer 11

Theophylline, Aminophylline

Question 12

Consideration:

plasma levels must be monitord to prevent toxic levels

Answer 12

Theophylline, Aminophylline

Question 13

MOA:

Inhibit calcium transport into smooth muscle cells= relaxation

Answer 13

Magnesium sulfate

Question 14

Tx:
atrial paroxysmal tachycardia
eclampsia
cerebral edema
barium poisoning
sz
hypomagnesia

Answer 14

magnesium sulfate

Question 15

Consideration:

Tocolytic agent causing uterine relaxation thus preventing preterm labor

Answer 15

magnesium sulfate

Question 16

MOA:

inhibit COX-2 action and prostglandin by inducing lipocortins

Answer 16

Inhaled corticosteroids

Question 17

Inhaled Corticosteroids (7)

Answer 17

Beclomethasone, Triamcinolone, Fluticasone, Budesonide, Flunisolide, Mometasone, Ciclesonide

Question 18

MOA:

Inhibit chloride transport, which affects calcium gating to prevent ganule release= decreased mast cell response

Answer 18

Cromolyns

Question 19

Cromolyns (2)

Answer 19

Cromolyn, Nedocromil

Question 20

Tx:

keratoconjunctivitis, mast-cell disorder, vernal conjunctivitis

Answer 20

Cromolyn, Nedocromil

Question 21

Considerations:
Good for exercise-induced asthma
primarily prophylactic therapy
Most affective in young adults & children

Answer 21

Cromolyn, Nedocromil

Question 22

MOA:

Inhibit 5-lipoxygenase= decreased leukotreine synthesis

Answer 22

Leukotriene pathway modifying agents

Question 23

MOA:

cysteinyl leukotreine receptor antagonist

Answer 23

Montelukast, Zafirlukast

Question 24

Leukotriene pathway modifying agents (3)

Answer 24

Zileuton, Montelukast, Zafirlukast

Question 25

MOA:
Humanized mouse, high affinity IgE-receptor, Prevents IgE from binding to receptor on mast cells; and decreases circulating IgE= decreased allergic response to asthma

Answer 25

Anti-immunoglobulin E antibodies

Question 26

Considerations:
High cost- limited to severe asthma
Administered every 2-4 weeks SQ

Answer 26

Omalizumab

Question 27

Anti-immunoglobulin E antibodies (1)

Answer 27

Omalizumab