Pharm 38 Cancer Drugs Mechanisms

Question 1

Mechanism: Inhibit thymidylate synthase

Answer 1

• Fluorouracil (5-FU), Capecitabine, Pemetrexed

- (FluCapPem)

Question 2

Inhibitors of Purine Metabolism

Answer 2

• 6-Mercaptopurine, Azathioprine, Pentostatin

- 6-MP and AZA inhibit IMPDH (Inosine Monophosphate Dehydrogenase) while Pentostatin inhibits adenosine deaminase (ADA)

Question 3

Inhibits Ribonucleotide Reductase

Answer 3

Hydroxyurea

Question 4

Purine Analogues

Answer 4

Thioguanine (Guanine), Fludarabine Phosphate (Purine), Cladribine (Adenosine)

Question 5

Pyrimidine Analogues

Answer 5

• Cytarabine (araC), Azacytidine, Decitabine, Gemcitabine (Bines and Dine)
• All are Cytidine Analogues

Question 6

Alkylating Agents (Covalently bind DNA)

Answer 6

Cyclophosphamide, Mechlorethamine, Melphalan, Estramustine

Question 7

Modify DNA Structure by Cross-linking intrastrand guanine bases

Answer 7

Cisplatin, Carboplatin, Oxaliplatin

- (Platinum Compounds)

Question 8

Binds oxygen and chelates Fe(II); binds DNA and leads to strand breaks via generation of oxidative intermediates

Answer 8

Bleomycin

Question 9

Inhibit Topoisomerase I, leading to DNA strand breakage

Answer 9

Irinotecan, Topotecan (Tecans Block Type I)

Question 10

Inhibit Topoisomerase II, leading to DNA strand breakage

Answer 10

• Doxorubicin, Daunorubicin, Epirubicin, Etoposide, Teniposide, Amsacrine
• Rubicins, Posides, and Amsacrine block Topo II

Question 11

Bind tubulin subunits and prevent microtubule polymerization (Bind to + end)

Answer 11

• Vinblastine, Vincristine, Eribulin (Vins and Bulins bind Tubulin)

Question 12

Bind polymerized tubulin and inhibit microtubule depolymerization

Answer 12

Paclitaxel, Abraxane, Docetaxel (Taxels and Xane)