Nicotinic and Muscarinic Receptors

Question 1

Muscarninc M1:
Location (2)
Responses (for each location)

Answer 1

CNS Autonomic ganglia 
Late EPSP (excitatory postsynaptic potential) ; complex at least arousal, attention analgesia

Question 2

Muscarninc M1:
Mechanism
Prototype agonist/antagonist

Answer 2

Gq/11 –> PLC –> IP3 + DAG –> Ca + PKC (all increase in concentration)
Oxotremorine / Pirenzepine

Question 3

Muscarininc M2:
Location (4)
Responses

Answer 3

All heart
SA node : slowed spontaneus depolarization, hyperpolarzation
AV node : decrease conduction velocity
Atrium : decreased refactory period : decreased contractile force
Ventricle : slight decrease in contractility

Question 4

Muscarninc M2:
Mechanism
Prototype agonist/antagonist

Answer 4

betagamma subunit of G Protein –> inhibits Adenylyl cyclase and increases potassium channel opening

none/ AF-DX117

Question 5

Muscarinic M3: 
Location (1) 
Response
Mechanism
Antagonist

Answer 5

smooth muscle
contraction
same as M1
hexahydrosiladifenidol

Question 6

Muscarninc M4/5
Location
Mechanism (2)
Antagonist for M4

Answer 6

CNS
M4–> M2 and M5 –> M1
Himbacine antagonizes M4

Question 7

Nicotinic Nm:
Locations
Response

Answer 7

Skeletal muscle at NMJ

End -plate depolarization; skeletal muscle contraction

Question 8

Nicotinic Nm:
Mechanim
Agonist/ antagonist

Answer 8

opening of Na/K channels

Phenyltrimethylammonium / Tubocurare

Question 9

Nicotininc Nn :
Location (3)
Responses ( for each loc. )

Answer 9

Autonomic Gnglia : deplarization and firing of postganglionic neuron
adrenal medulla : release of catecholamines
CNS : complex, arousal , attention, analgesia

Question 10

Nicotinic Nn:
Mechanism
Agonist/Antagonist

Answer 10

opening of Na/K channel

Dimethylphenylpiperazinium / Trimethaphan