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pharmacology lecom sh > Pharm 10 Adrenergics > Flashcards

Pharm 10 Adrenergics Flashcards

1
Q

rate limiting enyzme for catecholamine synthesis and the sole inhibitor of it

A

tyrosine hydroxylase; alpha- methyltyrosine

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2
Q

MOA of the inhibitors of catecholamine storage (ICS)

A

short term increase in catecholamine but long term depletion of available pool of catecholamines

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3
Q

ICS used for hyper tension (3)

A

Reserpine, guanethidine, guanadrel

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4
Q

ICS used for ADHD and narcolepsy

A

amphetamine (narcoleptics) , methylphenidate

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5
Q

ICS used for allergic rhinitis and Nasal Congestion

A

Pseudoephedrine

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6
Q

ADR : GI hemorrhage, thrombocytopenia, dream anxiety disorder impotence and psychotic depression

A

Reserpine

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7
Q

ADR: kidney disease , apnea , orthostatic hypotention fluid retention, dizziness , blurred vision, impotence

A

Guanethidine , guanafrel

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8
Q

ADR: hyper tension, tachyarrhythmia , Gilles de la Tourettes syndrome, seizure psychotic disorder w/ prolonged use

A

Amphetamine, Methylphenidate

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9
Q

ADR: A-fib, VPB, MI, insomnia, tachyarrhtymia, hypertension

A

Pseudophedirine

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10
Q

Irreversibly inhibits VMAT but rarley used because of its association with psychotic depression

A

Reserpine

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11
Q

Displaces norepinephrine from the storage vesicles. and can lead to reduced CO

A

Guanethidine, Guanadrel

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12
Q

Displace endogenous catecholamines and also weakyl inhibit MAO and block reuptake at NET and DAT, dependence is possible

A

Amphetamine, Methylphenidate

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13
Q

Inhibitors of Catecholamine Reuptake and at what receptor

A

Cocaine
Imipramine
Amitriptyline
@NET

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14
Q

INhibitors of MAO

A 
PICTureS of BoMBs
PHenelzine Brofaromine
Iproniazid Moclobemide 
clorgyline Befloxatone
Tranylcypromine
Selegine
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15
Q

Alpha1-adrenergic agonists (4) and Mechanism

A
  • Phenylephrine, Oxymetazoline, Tetrahydrazoline, Methoxamine (MetPhenOxyTet)
  • Increase peripheral resistance
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16
Q

INdicated for Opthalmic hyperemia and Nasal Congestion

A

Phenylephrine (can use in shock)
Oxymetazoline
Tetrahydrazoline

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17
Q

ADR bradycardia, ventricular ectopic beat

A

methoxamine

18
Q

ADR: cardiac arrythmia + hypertension. rebound nasal condition

A

Phenylephrine
Oxymetazoline
Tetrahydrazoline

19
Q

Alpha-2 adrenergic antagonists (5) and their MOA

A
  • Clonidine, Dexmedetomidine, Guanabenz, Guanfacine, Methyldopa
  • inhibit sympathetic outflow from CNS
20
Q

sedation of surgical and ICU pts

A

dexmedetomidine

21
Q

used for Opioid withdrawl or cancer pain

A

Clonidine

22
Q

ADR: hepatotoxicity, atoimmune hemolytic anemia

A

methyldopa

23
Q

ADR : bradycardia and heart failure (4)

A 
Clonidine
Dexmedetomidine
Guanabenz
Guanafacine
Methyldopa
24
Q

Used for Hypertenion assoc. with opioid withdrawl

A

Clonidine

25
Q

DRUG OF CHOICE for hypertension during pregnancy

A

Methyldopa

26
Q

Beta-adrenergic agonists (Mista D)

A 
Metaproterenol
Isoproterenol
Salmeterol
Terbutaline
Albuterol
Dobutamine
27
Q

Alpha-adrenergic antagonists MOA

A

block alpha 1 and 2 causing vasodilation, decreased BP and decreased peripheral resistance.

28
Q

Use for Pheochromocytoma-associated hypertension and sweating and Pre-Operative Management of Pheochromocytoma

A
  • Phenoxybenzamine and Phentolamine
29
Q

Use for Benign Prostatic Hyperplasia

A
  • Osins!

- Prazosin, Terazosin, Doxazosin, and Tamsulosin

30
Q

First Dose of these is generally prescribed in small quantities at bedtime due to potential severe postural hypotension

A
  • Zosins!

- Prazosin, Terazosin, Doxazosin

31
Q

Use for Organic and Psychogenic Impotence

A
  • Yohimbine
32
Q

Adverse Effects Include Bronchospasm, nervousness, tremor, increased blood pressure, and increased insulin release.

A
  • Yohimbine
33
Q

Alpha1-receptor Antagonist that has more specificity toward smooth muscle in genitourinary tract

A
  • Tamsulosin
34
Q

Beta-Adrenergic Antagonists and Major Use

A
  • “Olol” Drugs

- Hypertension and Angina

35
Q

Beta Antagonist Used for Glaucoma

A
  • Timolol
36
Q

Beta and Alpha1 Antagonists

A
  • Labetalol and Carvedilol
37
Q

Partial Agonists Among Beta Antagonists

A
  • Pindolol and Acebutolol
38
Q

Partial Agonist at Beta 1 and 2 receptors preferred in hypertensive patients who have bradycardia or decreased cardiac reserve

A
  • Pindolol
39
Q

Used for Emergency Beta Blockade, as in Thyroid Storm because of short half life

A
  • Esmolol
40
Q

Extremely lipophilic; CNS concentration is high enought hat sedation and decreased libido may result

A
  • Propanolol
41
Q

Beta1 Selective Antagonists

A
  • Esmolol, Metoprolol, Atenolol

pharmacology lecom sh (24 decks)

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