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Pharmacology LECOM SH > Ch. 12 GABA > Flashcards

Ch. 12 GABA Flashcards

1
Q

Inhibit GAT-1 or GABA transaminase= inhibit reuptake= more GABA in synapse

A

Tiagabine, Vigabatrin

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2
Q

Blocks GABA reuptake

A

Tiagabine

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3
Q

Blocks conversion of GABA to Succinic semialdehylde

A

Vigabatrin

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4
Q

GABA Receptor modulators- agonists to GABA= Increase Frequency of receptor opening= Inc. GABA

A

Benzodiazepine

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5
Q

Short acting Benzo:

A

Clorazepate, Midazolam, Triazolam, Zlopidem

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6
Q

Intermediate acting Benzo:

A

Alprazolam, Estazolam, Lorazepam, Temazepam

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7
Q

Long Acting Benzo:

A

Chlordiazepoxide, Clonazepam, Diazepam, Flurazepam, Quazepam

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8
Q

Benzo for tonic Sz:

A

Diazepam, Loraz, Midaz

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9
Q

Benzo for Status epilepticus

A

Midaz, Loraz

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10
Q

Benzo for Abscent sz

A

Clonaz

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11
Q

Benzo for amnesia

A

Midaz, Loraz

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12
Q

Benzo for anxiety

A

Alpraz, clonaz, diaz

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13
Q

Benzo for Alcohol Withdrawal

A

Chlordiazepoxide, Diaz

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14
Q

Benzo for Insomnia

A

zolpidem

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15
Q

metabolism of Benzo

A

Hepatic CYP 450

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16
Q

Consideration of Benzo

A

Cross BBB, Respiratory depression

17
Q

Reverse Benzo

A

Flumazenil

18
Q

GABA Receptor modulators- Increase Duration that Cl- receptors are open

A

Barbiturates

19
Q

Barb for anestheia

A

Thiopental

20
Q

Barb for insomnia

A

Pentobarbital, Thiopental, secobarbital, amobarbital

21
Q

Barb for Status epilepticus

A

Pentobarbital, amobarbital

22
Q

Barb for Increase Incracranial Pressure

A

Thiopental

23
Q

Considerations of Barbs

A

Lipid soluble= enter brain, CYP 450 inducers (phenytoin, rifampicin)= reduces barbs, CYP450 inhibitors (ketoconazole, EES, cimetidine, SSRI)= Enhance effect

24
Q

Long Acting Barb

A

Phenobarbital- Refr. Epilepsy (good for kids)

25
Q

GABA Receptor modulators- Modulate ligand-gated ion channels

A

Etomidate, Propofol

26
Q

GABA Receptor Agonist- Activate metabotropic GABA receptor

A

Baclofen (spacticity)- withdrawal can precipitate acute hyeprsaspticity, rhabdo, pruritis, delerium, fever)

27
Q

NMDA Receptor Antagonist affecting Glutamate neurotransmission

A

Riluzole, Memantine, Amantadine, Lamotrigine, Felbamate

28
Q

For ALS

29
Q

For Alzhemiers

30
Q

For Parkinsons

A

Amantadine

31
Q

For Bipolar I, Clonic Sz, with adverse= steven johnson

A

Lamotrigine

32
Q

For Refractory Epilepsy with adverse= aplastic anemia, hepatic failure

Pharmacology LECOM SH (24 decks)

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