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Test 11 > Pharm 6 Anti-virals > Flashcards

Pharm 6 Anti-virals Flashcards

1
Q

DNA virus RNA (protein transcription) blocker

A

Foscarnet

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2
Q

DNA virus DNA blocker (4)

A

Foscarnet
Trifluridine
Acyclovir
Gancyclovir

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3
Q

4 DNA viruses

A

Adenoviruses (pharyngoconjunctivitis)
Papillomaviruses
HSV
VZV

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4
Q

Acyclovir

A

Prodrug (Ac-TP)

  • SE Nausea, diarrhea
  • SE Transient renal dysfunction (hydrate)
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5
Q

Gancyclovir toxicity

A

Neutropenia

-CNS effects, carcinogenic

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6
Q

Foscarnet

A

Block DNA/RNA replication

  • Tx gancyclovir-resistant CMV
  • SE Nephrotoxicity
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7
Q

Trifluridine

A

Block DNA replication

  • Tx HSV keratoconjunctivitis
  • SE Corneal inflammation
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8
Q

HSV mnemonic

A

For herpes give Acyclovir To patient

  • Foscarnet
  • Acyclovir
  • Trifluridine
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9
Q

CMV mnemonic

A

For CMV give Gancyclovir

  • Foscarnet
  • Gancyclovir
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10
Q

Flu Tx

A

Neuraminidase inhibitors (prevention)

  • Zanamivir
  • Oseltamivir
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11
Q

Zanamivir SE

A

Bronchospasm in asthmatics

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12
Q

Oseltamivir SE

A

Nausea

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13
Q

Interferons

A

Immune response against virus

-Induce JAK-STAT in patients, cease protein transcription

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14
Q

Interferon indication

A 
Kaposi sarcoma
Hep C (w/Ribavirin)
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15
Q

Ribavirin mnemonic

A

RIBAvirin

  • RSV
  • Influenza B
  • Adenoviruses
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16
Q

Ribavirin SE

A

Anemia (systemic, not aerosol)

Teratogenic

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17
Q

HIV Tx indication

A

Not at CD4 above 400

18
Q

HAART therapy SE (4)

A

Metabolic syndrome (DM)
Lipodystrophy (hunchback)
Liver problems
Increased bleeding

19
Q

AZT

A

Thymidine-like reverse-transcriptase inhibitor

-Given for pregnant women

20
Q

AZT toxicity inducing drugs

A

PAL, I Care

  • Probenecid (gout)
  • Acetaminophen
  • Lorazepam
  • Indomethacin (NSAID)
  • Cimetidine (anti-H)
21
Q

AZT toxicity

A

-Bone marrow (anemia, leukopenia)

22
Q

Didanosine

A

AZT resistance

-SE severe (pancreas, liver)

23
Q

Zalcitabine

A

AZT adjunct

-SE peripheral neuropathy

24
Q

Stavudine SE

A
  • peripheral neuropathy

- lactic acidosis, hyperlipidemia (w/AZT)

25
Q

Lamuvidine

Emtricitabine

A

Slows AZT resistance

-SE pancreatitis in children

26
Q

Trizivir

A

Lamuvidine, Zidovudine (AZT), Abacavir

27
Q

Abacavir

A

Adjunct to AZT or Lamuvidine

-SE hypersensitivity reaction

28
Q

Tenofovir

A

Chain terminator, NRTI

  • Tx HIV, HBV
  • Prophylactic??
29
Q

Tenofovir SE

A
  • Flatulence

- CI with lamuvidine, abacavir, didanosine

30
Q

Nucleoside RT inhibitor mnemonic

A

ZIDdy went NUClear and DID STAB A BABy LAMb

  • Zidovudine
  • Didanosine
  • Stavudine
  • Abacavir
  • Lamivudine
31
Q

NNRTI mechanism

A

Modify reverse transcriptase conformation

32
Q

Efavirenz

A

NNRTI

  • Use with lamuvidine, AZT
  • SE CYP2B6 (psych) interactions
33
Q

Nevirapine

A

NNRTI

  • SE Rash
  • CI St. John’s wort
  • lowers estrogen OC effectiveness
34
Q

Delavirdine

A

NNRTI

-CYP3A4 interactions (psych, rifampin)

35
Q

Protease inhibitor -suffix

A

-navir

36
Q

Good protease inhibitor Tx for resistant HIV

A

Amprenavir

-Lopinavir/Ritonavir

37
Q

Enfuvirtide

A 
Fusion inhibitor (hemagglutinin)
-Inject twice daily
38
Q

Maraviroc

A 
Fusion inhibitor (CCR5 chemokine-R)
-Many toxicities
39
Q

DNA virus Tx -suffix

A

-lovir-

40
Q

RNA virus Tx -suffix

A
  • ine
  • mivir
  • avir

Test 11 (27 decks)

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