Micro 6 Herpes

Question 1

Most common herpes meningitis

Answer 1

HSV-2

Question 2

Most common herpes encephalitis

Answer 2

HSV-1

Question 3

Neonatal HSV

Answer 3

Disseminates quickly because cell-mediated immunity hasn’t developed yet

Question 4

EBV

Answer 4

Mononucleosis

Question 5

EBV cancer

Answer 5

Burkitt’s lymphoma (africa)
Nasopharyngeal carcinoma (asia)
-Hodgkin’s lymphoma, Gastric Carcinoma
-AIDS lymphoma

Question 6

EBV mechanism

Answer 6

Transforms B-lymphocytes

Question 7

EBV lytic phase

Answer 7

Not responsible for disease

• Blocked by herpes antivirals
• Associated with hairy cell leukoplakia (AIDS)

Question 8

EBV latent phase

Answer 8

Associated with disease

-No Tx

Question 9

EBV test

Answer 9

Heterophile Ab test (monospot), tests IgM Ab released by infected B cells

Question 10

EBV Dx

Answer 10

Atypical lymphocytes (downey cells)

Question 11

Burkitt’s lymphoma histo

Answer 11

Starry sky (sea of tumor cells with infiltrating immune cells)

Question 12

Burkitt’s lymphoma genetics

Answer 12

c-myc - Ig translocation

Question 13

HHV-5

Answer 13

CMV

Question 14

CMV mononucleosis

Answer 14

Heterophile Ab negative

Question 15

CMV histo

Answer 15

Owl’s eye intranuclear inclusion

Question 16

CMV complication

Answer 16

Transplant organ failure (immunocompromised)

Question 17

CMV Tx

Answer 17

Gancyclovir - neutropenia

Cidofovir - nephrotoxic

Question 18

EBV Tx

Answer 18

Symptom support

Question 19

Cytomegalic inclusion disease

Answer 19

Newborns - normal disabilities (CNS, growth, rash)