Micro 12 Retro

Question 1

Retrovirus micro

Answer 1

RNA with

• reverse transcriptase
• integrase

Question 2

Transformation

Answer 2

Genetic alteration of a cell after uptake and expression of foreign genetic material

Question 3

HTLV infection

Answer 3

Sexual contact -> T (CD4) infection

Question 4

HTLV mechanism

Answer 4

• tax turns on IL-2, IL-2 receptor

- p53, MAD inactivation

Question 5

ATL Tx

Answer 5

CHOP and VCAP

Question 6

HB/CV cancer

Answer 6

Hepatocellular carcinoma

Question 7

EBV malignancy

Answer 7

Lymphoma (burkitt, hodgkin, AIDS, transplant)
Gastric carcinoma
Nasopharyngeal carcinoma

Question 8

EBV gene

Answer 8

c-myc translocation

Question 9

Kaposi’s sarcoma histo

Answer 9

Spindle cells

Extravasated erythrocytes

Question 10

Gardasil

Answer 10

Quadrivalent

Question 11

Cervarix

Answer 11

Bivalent

Question 12

MAD mechanism

Answer 12

Mitotic spindle assembly checkpoint - prevent aneuploidy

Question 13

c-myc mechanism

Answer 13

Accelerate cells through G1 and S, bypass checkpoints

Question 14

pRB mechanism

Answer 14

Bind to and inactivate E2F proteins (transcriptional activators)

Question 15

p53 mechanism

Answer 15

DNA damage triggers cell cycle arrest in G1 or apoptosis

Question 16

EBV in AIDS

Answer 16

Primary CNS lymphoma

Question 17

HBV mechanism

Answer 17

Integrate DNA into host

Question 18

HCV mechanism

Answer 18

RNA does not integrate