Micro 8 Arboviruses

Question 1

Arbovirus basic

Answer 1

Tic/mosquito vector

• RNA genome
• Initial replication in endothelial and macrophage cells

Question 2

4 Arboviruses

Answer 2

Togavirus (equine encephalitis)
Bunyavirus
Flavivirus (main)
Reovirus

Question 3

Only non bird/rodent host viruses

Answer 3

Dengue, Yellow fever (human/primate)

Question 4

Reovirus

Answer 4

Colorado tic fever

Question 5

Togavirus micro

Answer 5

+ssRNA, enveloped

Question 6

Bunyavirus micro

Answer 6

-ssRNA, enveloped

Question 7

Flavivirus micro

Answer 7

+ssRNA, enveloped

Question 8

Reovirus micro

Answer 8

dsRNA, nonenveloped

Question 9

Arbovirus general pathology

Answer 9

Encephalitis, Fever, Hemorrhagic fever

Question 10

Hemorrhagic fever

Answer 10

Liver replication

-Dengue, Yellow fever

Question 11

Viral encephalitis

Answer 11

Human is dead end host

Question 12

Arbovirus Dx

Answer 12

Serology

Question 13

Arbovirus Tx

Answer 13

Symptom support

Question 14

Reovirus

Answer 14

Similar to RMSF

-Possible mild encephalitis

Question 15

West Nile Virus vector

Answer 15

Culex mosquito

Question 16

West Nile buzzword

Answer 16

Arbovirus with flaccid paralysis

Question 17

Viral Hemorrhagic Fever

Answer 17

Macrophage/Dendritic cell infection leads to cytokine wave, vascular damage, and shock
-Conjunctivitis, petechiae, ecchymosis

Question 18

Hemorrhagic Fever labs

Answer 18

Thrombocytopenia, leukopenia, anemia, elevated liver enzymes, proteinuria/hematuria

Question 19

Hemorrhagic Fever virus micro

Answer 19

Enveloped RNA

Question 20

Hemorrhagic Fever danger

Answer 20

Shock, not bleeding

Question 21

Hemorrhagic Fever Tx

Answer 21

Ribavirin only for Arena and Bunya viruses (Hanta)

Question 22

Yellow fever - jungle vs urban

Answer 22

Primate->human v. human->human

Question 23

Yellow fever symptoms

Answer 23

Bradycardia, jaundice, hemorrhagic fever (hypotension and oliguria)

Question 24

Yellow fever Dx

Answer 24

Serology

Question 25

Yellow fever Tx

Answer 25

Symptom support | Live attenuated vaccine

Question 26

Dengue micro

Answer 26

Flavivirus, 4 serotypes

Question 27

Dengue fever

Answer 27

Fever, lymphadenopathy, bone/joint pain, headache (breakbone fever) -Hemorrhagic fever if previously infected/mother infected (immunopathological)

Question 28

Dengue Tx

Answer 28

Symptom support | -Vaccine difficult due to 4 serotypes

Question 29

2 Filovirus

Answer 29

Ebola, Marburg

Question 30

Ebola symptoms

Answer 30

Fever, GI symptoms, chest pain, delerium, severe hemorrhagic fever

Question 31

Ebola danger

Answer 31

50% death

Question 32

Ebola transmission

Answer 32

Direct contact, nosocomial

Question 33

Bunyavirus

Answer 33

Hantavirus | -Transmitted by rodents

Question 34

Hantavirus symptoms

Answer 34

Pulmonary syndrome, renal syndrome, hemorrhagic fever

Question 35

Arenavirus

Answer 35

Lassa virus (africa)

Question 36

Arenavirus transmission

Answer 36

Rodent feces

Question 37

Arenavirus hemorrhagic fever

Answer 37

Typical hemorrhagic fever + neurologic signs

Question 38

DIC Tx

Answer 38

Transfusion

Question 39

Pregnant woman Dengue differential

Answer 39

HELLP syndrome (hemolysis, elevated liver enzymes, low platelets)