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Test 11 > Micro 8 Arboviruses > Flashcards

Micro 8 Arboviruses Flashcards

1
Q

Arbovirus basic

A

Tic/mosquito vector

  • RNA genome
  • Initial replication in endothelial and macrophage cells
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2
Q

4 Arboviruses

A

Togavirus (equine encephalitis)
Bunyavirus
Flavivirus (main)
Reovirus

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3
Q

Only non bird/rodent host viruses

A

Dengue, Yellow fever (human/primate)

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4
Q

Reovirus

A

Colorado tic fever

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5
Q

Togavirus micro

A

+ssRNA, enveloped

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6
Q

Bunyavirus micro

A

-ssRNA, enveloped

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7
Q

Flavivirus micro

A

+ssRNA, enveloped

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8
Q

Reovirus micro

A

dsRNA, nonenveloped

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9
Q

Arbovirus general pathology

A

Encephalitis, Fever, Hemorrhagic fever

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10
Q

Hemorrhagic fever

A

Liver replication

-Dengue, Yellow fever

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11
Q

Viral encephalitis

A

Human is dead end host

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12
Q

Arbovirus Dx

A

Serology

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13
Q

Arbovirus Tx

A

Symptom support

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14
Q

Reovirus

A

Similar to RMSF

-Possible mild encephalitis

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15
Q

West Nile Virus vector

A

Culex mosquito

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16
Q

West Nile buzzword

A

Arbovirus with flaccid paralysis

17
Q

Viral Hemorrhagic Fever

A

Macrophage/Dendritic cell infection leads to cytokine wave, vascular damage, and shock
-Conjunctivitis, petechiae, ecchymosis

18
Q

Hemorrhagic Fever labs

A

Thrombocytopenia, leukopenia, anemia, elevated liver enzymes, proteinuria/hematuria

19
Q

Hemorrhagic Fever virus micro

A

Enveloped RNA

20
Q

Hemorrhagic Fever danger

A

Shock, not bleeding

21
Q

Hemorrhagic Fever Tx

A

Ribavirin only for Arena and Bunya viruses (Hanta)

22
Q

Yellow fever - jungle vs urban

A

Primate->human v. human->human

23
Q

Yellow fever symptoms

A

Bradycardia, jaundice, hemorrhagic fever (hypotension and oliguria)

24
Q

Yellow fever Dx

A

Serology

25
Q

Yellow fever Tx

A

Symptom support

Live attenuated vaccine

26
Q

Dengue micro

A

Flavivirus, 4 serotypes

27
Q

Dengue fever

A

Fever, lymphadenopathy, bone/joint pain, headache (breakbone fever)
-Hemorrhagic fever if previously infected/mother infected (immunopathological)

28
Q

Dengue Tx

A

Symptom support

-Vaccine difficult due to 4 serotypes

29
Q

2 Filovirus

A

Ebola, Marburg

30
Q

Ebola symptoms

A

Fever, GI symptoms, chest pain, delerium, severe hemorrhagic fever

31
Q

Ebola danger

A

50% death

32
Q

Ebola transmission

A

Direct contact, nosocomial

33
Q

Bunyavirus

A

Hantavirus

-Transmitted by rodents

34
Q

Hantavirus symptoms

A

Pulmonary syndrome, renal syndrome, hemorrhagic fever

35
Q

Arenavirus

A

Lassa virus (africa)

36
Q

Arenavirus transmission

A

Rodent feces

37
Q

Arenavirus hemorrhagic fever

A

Typical hemorrhagic fever + neurologic signs

38
Q

DIC Tx

A

Transfusion

39
Q

Pregnant woman Dengue differential

A

HELLP syndrome (hemolysis, elevated liver enzymes, low platelets)

Test 11 (27 decks)

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