Pharm 4 Anti-malarial

Question 1

Plasmodium falciparum disease

Answer 1

Cerebral malaria

Question 2

Chloroquine

Answer 2

1st line

• Erythrocide
• Transporter resistance in falciparum

Question 3

Quinine/Quinidine

Answer 3

Falciparum 1st line

• Erythrocide for all
• Gametocide for vivax, ovale
• Given with doxycycline

Question 4

Prophylactic

Answer 4

Mefloquine

Question 5

Primaquine

Answer 5

Adjunct to eliminate hepatic schizontes

-Only Tx for hypnozoites

Question 6

2 folate synthesis inhibitors

Answer 6

Pyrimethamine
Sulfanomides (sulfadoxine)

Question 7

2 drugs contraindicated with G6PD (too much oxidative stress)

Answer 7

Chloroquine

Primaquine

Question 8

Malaria requiring 2 drugs (hepatic, erythro)

Answer 8

P. ovale

P. vivax

Question 9

Gametocidal drugs

Answer 9

Chloroquine

Quinidine/Quinine

Question 10

Hepatocidal drugs

Answer 10

Primaquine

Metronidazole

Question 11

Adjunct antibiotic for erythrocide

Answer 11

Doxycycline

Question 12

Falciparum Tx

Answer 12

Oral quinine

IV quinidine + doxycycline

Question 13

Hemozoin

Answer 13

Malaria sequestered heme to prevent oxidative damage

Question 14

Hemozoin Tx

Answer 14

Chloroquine prevents hemozoin formation

Question 15

Chloroquine synonym

Answer 15

Quinolone

Question 16

Chloroquine resistance

Answer 16

PfCRT (chloroquine resistance transporter) pump

Question 17

Chloroquine adjunct

Answer 17

Metronidazole for hypnozoites

Question 18

Chloroquine contraindications

Answer 18

G6PD

• Psoriasis, porphyria
• Retinal abnormalities

Question 19

Quinine toxicity

Answer 19

Cardiotoxic

Question 20

Quinine SE

Answer 20

• Cinchonism - tinnitis, headache, GI

- Blackwater fever - hypersensitivity hemolysis

Question 21

Mefloquine

Answer 21

Prophylactic erythrocide

Question 22

Hypnozoite (vivax, ovale) Tx

Answer 22

Primaquine

Question 23

Pregnancy Tx

Answer 23

Chloroquine

Question 24

Folate synthesis inhibitor

Answer 24

Pyrimethamine

Question 25

Artemisinin

Answer 25

Most powerful antimalarial

• Block hemozoin
• Produce toxic hemart