Pharm 4 Anti-malarial Flashcards
1
Q
Plasmodium falciparum disease
A
Cerebral malaria
2
Q
Chloroquine
A
1st line
- Erythrocide
- Transporter resistance in falciparum
3
Q
Quinine/Quinidine
A
Falciparum 1st line
- Erythrocide for all
- Gametocide for vivax, ovale
- Given with doxycycline
4
Q
Prophylactic
A
Mefloquine
5
Q
Primaquine
A
Adjunct to eliminate hepatic schizontes
-Only Tx for hypnozoites
6
Q
2 folate synthesis inhibitors
A
Pyrimethamine Sulfanomides (sulfadoxine)
7
Q
2 drugs contraindicated with G6PD (too much oxidative stress)
A
Chloroquine
Primaquine
8
Q
Malaria requiring 2 drugs (hepatic, erythro)
A
P. ovale
P. vivax
9
Q
Gametocidal drugs
A
Chloroquine
Quinidine/Quinine
10
Q
Hepatocidal drugs
A
Primaquine
Metronidazole
11
Q
Adjunct antibiotic for erythrocide
A
Doxycycline
12
Q
Falciparum Tx
A
Oral quinine
IV quinidine + doxycycline
13
Q
Hemozoin
A
Malaria sequestered heme to prevent oxidative damage
14
Q
Hemozoin Tx
A
Chloroquine prevents hemozoin formation
15
Q
Chloroquine synonym
A
Quinolone
