Pharm 5 Anti-parasite Flashcards
American Trypanosome (chaga) Tx
Nifurtimox
African Trypanosome Tx (3)
Suramin
Melarsoprol
Eflornithine
Suramin
Trypanosome brucei
- Chemoprophylaxis
- Lymphatic (acute) Tx
- doesn’t cross BBB
Suramin adjunct
Pentamidine
Melarsoprol class
Arsenicals
Melarsoprol
Trypanosome brucei
- First line for CNS Tx
- Serious side effects (G6PD)
Eflornithine
Trypanosome brucei
- Inhibits ornithine decarboxylase
- Blocks conversion to putrescine
Nifurtimox
Trypanosome cruzi
-Only for acute (hemolymphatic) phase, not too effective
Leishmaniasis Tx
Sodium Stibogluconate
Metronidazole parasites
Amebiasis, Giardiasis, Trichomoniasis
Balantidiasis Tx
Tetracycline
Metronidazole SE
Dark urine
-Disulfiram-like with alcohol (circulatory collapse)
Metronidazole MOA
Only penetrate anaerobe cells
-Gets reduced, breaks DNA
2 lumenal amebiasis Tx
Iodoquinol
Paromomycin sulfate
Metronidazole resistant Giardia Tx
Nitazoxanide
Nitazoxanide
Blocks pyruvate:ferridoxin oxidoreductase pathway (like metronidazole)
Mebendazole
Helminth Tx
- Inhibit microtubule synthesis
- Eat with fatty meal
Pyrantel pamoate
Nematode Tx
- ACh (N) agonist
- poorly absorbed -> lumenal
Praziquantel
Cestode, Trematode, Fluke Tx
-Increase Ca permeability
Piperazine
Nematode Tx
- ACh inhibitor
- hypersensitivity SE
Ascariasis
Intestinal nematode infection
Albendazole
Avoid in pregnancy
Niclosamide
Cestode Tx
-Praziquantel alternative
Schistosoma Tx
Praziquantel
