Pharm 5 Anti-parasite Flashcards
1
Q
American Trypanosome (chaga) Tx
A
Nifurtimox
2
Q
African Trypanosome Tx (3)
A
Suramin
Melarsoprol
Eflornithine
3
Q
Suramin
A
Trypanosome brucei
- Chemoprophylaxis
- Lymphatic (acute) Tx
- doesn’t cross BBB
4
Q
Suramin adjunct
A
Pentamidine
5
Q
Melarsoprol class
A
Arsenicals
6
Q
Melarsoprol
A
Trypanosome brucei
- First line for CNS Tx
- Serious side effects (G6PD)
7
Q
Eflornithine
A
Trypanosome brucei
- Inhibits ornithine decarboxylase
- Blocks conversion to putrescine
8
Q
Nifurtimox
A
Trypanosome cruzi
-Only for acute (hemolymphatic) phase, not too effective
9
Q
Leishmaniasis Tx
A
Sodium Stibogluconate
10
Q
Metronidazole parasites
A
Amebiasis, Giardiasis, Trichomoniasis
11
Q
Balantidiasis Tx
A
Tetracycline
12
Q
Metronidazole SE
A
Dark urine
-Disulfiram-like with alcohol (circulatory collapse)
13
Q
Metronidazole MOA
A
Only penetrate anaerobe cells
-Gets reduced, breaks DNA
14
Q
2 lumenal amebiasis Tx
A
Iodoquinol
Paromomycin sulfate
15
Q
Metronidazole resistant Giardia Tx
A
Nitazoxanide
