Peptic Ulcer Disease Flashcards
When do peptic ulcers occur?
When balance between aggressive factors and defensive mechanisms are disrupted
What aggressive factors can alter mucosal defense?
NSAIDS, H pylori infection, bile salts and pepsin
How are ulcer sx characterized
Rhythmicity and periodicity
10-20% of ulcers occur w/o what?
Antecedent sx
Are NSAID induced ulcers symptomatic or asymptomatic?
Asymptomatic
Where are 95% of peptic ulcers found?
Bulb or pyloric channel
What percentage of benign ulcers are located in the antrum?
60%
What percentage of benign ulcers are located junction of the antrum and body on the lesser curvature?
25%
Do peptic ulcers occur more commonly in men or women?
Men
What makes patients more susceptible to peptic ulcers?
Smoking and taking NSAIDs
What are the 3 major causes of peptic ulcer disease?
NSAIDs
Chronic H pylori infection
Acid hypersecretory states
How many patients with H pylori will develop peptic ulcer disease?
1 in 6
What is the hallmark sx of peptic ulcer disease?
Epigastric pain in 80-90% of patients
What percentage of patients report relief of pain with food or antacids and recurrence 2-4hours later?
50%
2/3 of duodenal ulcers and 1/3 of gastric ulcers cause what to patients?
Nocturnal awakenings form pain
