Penicillin Miller

Question 1

Peptidoglycan Membrane made up of

Answer 1

NAG and NAM units
NAM units usually have 5 AA hanging down
Connect NAM to NAM
Last two AA are usually D-Alanines –> one will be removed during connection process and only four AA will remain

Question 2

What mediates the crosslinking of peptidoglycan layer or transpeptidation?

Answer 2

Glycopeptide transpeptidase a PBP

Question 3

Penicillins primary actions is through?

Answer 3

Suicide inhibition of glycopeptide transpeptidase

Question 4

Penicillins act as

Answer 4

haptens – must bind to a larger molecule to get around so they grab the attention of the immune system

Question 5

R1 vs R2 on cephalosporins

Answer 5

R1: activitiy
R2: PK and Metabolism

Question 6

Cephalosporins MOA

Answer 6

Inhibit the last step of bacterial cell wall synthesis (transpeptidation)

Question 7

Cefotriaxone Special properties

Answer 7

Longer halflife –> once daily dosing

IV

Question 8

Gram Positive Bugs

Answer 8

Staph
Strep
Enteroccus
Listeria
Bacillus
Above the diaphram bugs
Clostridium

Question 9

Key Gram Negatives

Answer 9

Pseudomonas
HEN PEcK
Citrobacter
Morganella
Providencia
Serratia
Escherichia
Helicobacter
Bordetella
Burkholderia
Morazella cattahralis
Below the diaphram
Bacteroides

Question 10

Atypicals

Answer 10

Chlamydia
Mycoplasma
Legionella
Brucella
Francisella
Rikettsia
Mycobacteria