CNS Infection'

Question 1

Define Meningitis

Answer 1

Any infection or inflammation of the membranes covering the brain and spinal cord
Bacterial

Question 2

Define Encephalitis

Answer 2

Infection or inflammation of the brain tissue (parenchyma)

Viral

Question 3

Define hematogenous

Answer 3

Colonize in the nasopharynx then invade through the cerebral vessels
Via bloodstream

Question 4

Define Contiguous

Answer 4

Secondary route, organisms spread locally from a nearby infection

Question 5

Signs and symptoms

Answer 5

Lethargy, altered mental status, seizures, stiff neck/back

Rash

Question 6

PE

Answer 6

Kernig’s sign (pain in neck when bending knee)

Brudzinski’s (Lift head and legs come up)

Question 7

Meningitis

Answer 7

High neutrophils
Low glucose
High proteins

Question 8

Steroids in meningitis infection dose

Answer 8

BEFORE antibiotics

Dexamethasone 10 mg IV Q6H x 4d

Question 9

Good CSF penetration requires?

Answer 9

Lipophilic
Smaller
Non-ionized
Low protein binding
Less efflux pump activity

Question 10

Drugs for with inflammation

Answer 10

Beta lactams
Colistin
Dapto
Vanco

Question 11

Cefotaxime or Ampicillin Dose

Answer 11

2 g IV Q4H

Question 12

Ceftraixone Dose

Answer 12

2 g IV Q12H

Question 13

Vanco

Answer 13

30-40 mg/kg/dose

Target Trough 15-20