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ID Final > Pathophysiology of Infection > Flashcards

Pathophysiology of Infection Flashcards

1
Q

Define Infectious Disease

A

Invasion and multiplication of microorganisms in body tissues, especially that causing local cellular injury due to competitive metabolism, toxins, intracellular replication or antigen-antibody response

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2
Q

Steps of Pathogenesis of infection

A 
Encounter
Colonization
Evasion 
Spread
Cell/Tissue damage
Shedding
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3
Q

Encounter

A 
Direct contact 
Inhalation/droplet infection
Ingestion
Trauma
Transplacental
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4
Q

Colonization

A

Attachment to host
Survival and replication
Colonization

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5
Q

Invasion

A

Penetration

Spread

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6
Q

Innate Immune

A 
Generalized initial response 
1-12 hrs
Low specificity
No memory
Phagocytes & NK cells
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7
Q

Adaptive immunity

A 
Tailored follow up response
1-5 days
High specificity
Memory
B& T lymphocytes
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8
Q

Secretory IgA

A

Block organism adhesion

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9
Q

Pulmonary Components of the Immune System

A 
Nasal barrier
Cough reflex
mucocillary clearance
Ab
Phagocytosis
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10
Q

GI Components of the Immune System

A 
pH
Indigenous flora
Mechanical flushing
Bacteriocins
Mucus
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11
Q

Eye Components of the Immune System

A

Tears
Lysozyme
Secretory IgA

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12
Q

Skin Components of the Immune System

A

Sweat
Sebum
Dryness

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13
Q

Genitourinary Components of the Immune System

A

Urine

Lactic acid

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14
Q

Define Virulence

A

Decree of pathogenicity of an organism or its ability to cause a disease

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15
Q

Define Virulence factors

A

genetically related factors that demonstrate biochemical evidence of damaging potential

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16
Q

Defensive functions

A 
Attachment
Adherence
Recognition and destruction
Proliferation
Change in surface to avoid recognition
17
Q

Offensive function

A

Tissue Damage
Invasion toxin production
Dissemination

18
Q

Exotoxins

A

Secreted

Cause infection symptoms

19
Q

Endotoxins

A

Released upon degradation

ID Final (31 decks)

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