Glycopeptids and other Beta Lactams Miller Flashcards
1
Q
Ertapenem
A
Not active against pseudomonas or enterococcis
Less active against gram +
2
Q
Pseudomonas develops resistance via
A
Mutations of porins
3
Q
Meropenem use
A
Meningitis due to less likely of carbapenems to cause seizures
4
Q
Beta Lactams MOA
A
Block crosslinking that is done by glycopeptide transpeptidase
5
Q
Glycopeptides MOA
A
Block polymerization that is done by transglycosylase
Teratogenic
6
Q
Resistant to Vanc
A
Entercocci
Staph Aureus
7
Q
Development of Resistance
A
Mutation of the binding site
Target modification
8
Q
Glycopeptides AE
A
Prolong QT
Teratogenic
Redman’s
Nephro and ototoxicity