Glycopeptids and other Beta Lactams Miller Flashcards

1
Q

Ertapenem

A

Not active against pseudomonas or enterococcis

Less active against gram +

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2
Q

Pseudomonas develops resistance via

A

Mutations of porins

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3
Q

Meropenem use

A

Meningitis due to less likely of carbapenems to cause seizures

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4
Q

Beta Lactams MOA

A

Block crosslinking that is done by glycopeptide transpeptidase

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5
Q

Glycopeptides MOA

A

Block polymerization that is done by transglycosylase

Teratogenic

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6
Q

Resistant to Vanc

A

Entercocci

Staph Aureus

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7
Q

Development of Resistance

A

Mutation of the binding site

Target modification

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8
Q

Glycopeptides AE

A

Prolong QT
Teratogenic
Redman’s
Nephro and ototoxicity

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