PD and hypokinetic dz

Question 1

Signs of PD

Answer 1

TRAP, usually asymmetric at onset progressing to symmetry; tremor resting, rigidity, akinesia, postural instability (late in dz course)

Question 2

pathologic hallmark of PD and what is it mde of

Answer 2

Lewy Body; alpha synuclein

Question 3

nonmotor symptoms of PD

Answer 3

Anxiety, depression, sleep disturbance, constipation, olfactory problems

Question 4

acronym for PD drugs

Answer 4

BALSA: Bromocriptine, Amantidine, L-dopa, Selegiline, Antimuscarinics

Question 5

Progressive suptranuclear palsy

Answer 5

like parkinsons except with supranuclear gaze palsy and unresponsive to drugs

Question 6

Selegiline

Answer 6

MAO-B inhibitor.

Question 7

L-dopa, carbidopa: mechanisms, long term side effects

Answer 7

crosses BBB, converted by dopa decarboxylase; inhibits peripheral decarboxylase activity to concentrate L-dopa in CNS. Dyskinesias, arrhythmias

Question 8

amantidine: mechanism, toxicity, other uses

Answer 8

increase dopamine release. Toxicity=ataxia. Also used in Influenza A

Question 9

Bromocriptine

Answer 9

ergot. Dopamine agonist

Question 10

Antimuscarinics

Answer 10

Benztropine (PARK your BENZ). curbs cholinergic activity. Good for tremor but little actual use

Question 11

DBS: who and when

Answer 11

PD ppl who DO respond to meds. When you can’t get a good dosing. Risk of stroke, infection