MS Flashcards
who gets MS
young women from northern latitudes
What are some possible exposures that may lead to MS
Infection or Vitamin D deficiency
Genetics of MS
HLA DR2*1501
what is an exacerbation
neurological disturbance lasting at least 24 hrs in absence of fever or infection
Common presenting symptoms of MS
sensory disturbance, optic neuritis, motor disturbance, brainstem/cerebellar problems (vertigo, diplopia), bladder, congnitive, pain
Lhermitte’s
brief electrical shock down spine on neck flexion
uhtoff’s phenomenon
symptoms in setting of elevated body temp
visual findings in MS
APD, nystagmus, INO, optic pallor
motor deficits in MS
increased tone, brisk reflexes, clonus, babinski
Findings of MS pts
elevated IgG on LP (esp oligoclonal bands), periventricular plaques on MRI. Dawsons fingers in saggital MRI (brain atrophy due to axon loss)
Normal dz course. Other courses
Relapsing-remitting MS (no full recovery from exacerbations). Can progress to Secondary Progressive (gets worse b/w exacerbations). Primary progressive has no exacerbations
tx of acute exacerbation
steroids (methylprednisolone)
preventative tx. which to use during pregnancy?
IFN beta, glatiramer acetate (pregnancy), natalizumab
best way to tx gait problems
K channel blocker
Neuromyelitis optica (devic’s dz)
optic neuritis, acute myelitis, longitudinally extensive spinal cord lesion (>3vertebrae), ab against aquaporin 4
