ALS Flashcards
1
Q
motor deficits seen in ALS? Sensory? Exceptions?
A
UMN and LMN sparing the EOM. No sensory or cognitive deficits. No autonomic involvement
2
Q
presentation of ALS
A
fasciculations with eventual atrophy progressing to respiratory failure
3
Q
causes of ALS
A
defect in superoxide dismutase 1, Gain of function
4
Q
Treatment
A
Riluzole increases survival by decreasing presynaptic glutamate
5
Q
what tracts does ALS affect
A
bulbar as well as somatic
6
Q
ALS-frontotemporal dementia: caused by
A
in familial ALS, hexanucleotide repeat
7
Q
glutamate hypothesis
A
too much Glu which cant be efficiently taken up by transporters. Acts on NMDA and nonNMDA receptors
