NMJ dz Flashcards
1
Q
what determines the number of quanta released from the presynaptic swelling
A
calcium concentration (voltage gated Ca channels)
2
Q
safety factor for transmission
A
EPP is usually 3-4 times larger than needed
3
Q
What type of Na channels are there postsynaptically
A
ligand gated Na channels (AChR) and voltage gated (outside of NMJ)
4
Q
LEMS: what Ig? associated with what neoplasm? what pattern is affected?
A
IgG against presynaptic Ca channel, small cell lung cancer, legs and arms (MG is more face), proximal>distal, improves with use
5
Q
MG: pathology? presentation? associated with? tx? What other receptor can cause MG?
A
ab’s against alpha subunit of AChR. Reduces number of AChR. Fatigue, ptosis, diplopia. Thymoma, thymic hyperplasia. pyridostigmine. Anti MuSK
