PBL Topic 3 Case 4 Flashcards
How is sound energy transmitted through a gaseous, liquid or solid medium?
- Setting up vibration of the medium’s molecules
What is a decibel and why is loudness measured in this way?
- Logarithmic function of sound pressure
- The human ear can detect an enormous range of volume variations
What determines the pitch of a sound that we hear?
- Frequency
- Measured in hertz
- The faster the vibration, the higher the pitch
What is the zone of compression of a sound wave?
- Molecules are close together
- Pressure is increased
What is the zone of compression of a sound wave?
- Molecules are further apart
- Pressure is lower
How does the zone of compression affect the tympanic membrane
- Under high pressure the tympanic membrane bows inward
- The distance that it moves depends on the force that the molecules hit it, which is related to pressure and hence loudness
How does the zone of rarefaction affect the tympanic membrane
- Under low pressure the tympanic membrane bows outward
What is the role of the pharyngotympanic tube
- When open, it maintains a pressure in the middle ear that is equal to atmospheric pressure
What is the role of the ossicles of the middle ear?
- They act as a single piston
- That couple the vibrations of the tympanic membrane to the oval window.
Why is the force exerted on the oval window much greater than that exerted on the tympanic membrane?
- The total force applied to the tympanic membrane is exerted onto the oval window
- The oval window is much smaller than the tympanic membrane
- Therefore the force per unit area is much greater
What is the attenuation reflex?
- Loud sounds in the middle ear cause contraction of tensor tympani
- Tensor tympani pulls handle of malleus medially
- Stapedius moves stapes posteriorly
- Increasing rigidity in middle ear
- Reducing conduction of loud damaging sounds
Where is endolymph located and secreted, and what are its contents?
- Cochlear duct
- Secreted by stria vascularis
- High potassium and low sodium concentration
Where is perilymph located and what are its contents?
- Scala vestibuli and scale tympani
- High sodium concentration and low potassium concentration
What causes vibration of the basilar membrane?
- Movement of stapes causing oval window to bow medially
- Causing pressure waves in the scala vestibuli
- The pressure waves are transmitted across the cochlear duct
- And cause the basilar membrane to vibrate in the direction of the round window
Where does high frequency resonance occur and why?
- Near the base of the cochlea duct
- Where the basilar fibres are short and stiff
- Which vibrate better at high frequency
Where does low frequency resonance occur and why?
- Near the helicotrema
- Where the basilar fibres are long and thin
- And vibrate better at low frequency
Where is the organ of Corti located and what is its structure?
- On the surface of the basilar fibres of the basilar membrane
- A single row of larger internal hair cells
- Three or four rows of external hair cells
- Tectorial membrane
Outline how depolarisation of hair cells occurs
- Pressure waves displace the basilar membrane
- Stereocilia bend in the direction of the longer hairs
- Which causes tip links to open cation channels
- Large influx from rich endolymph from cochlear duct into the hair cell which depolarises the membrane
Outline how cochlear nerve endings are stimulated by an excited hair cell
- As a result of potassium influx
- There is opening of voltage gated calcium channels
- Which release glutamate that binds to binding sites on the afferent neurons
What is the role of outer hair cells?
- Outer hair cells sharpen frequency tuning at each point along membrane
Where are the dorsal and ventral cochlear nuclei located?
- Upper part of the medulla
Outline the projections of the dorsal cochlear nucleus to the inferior colliculi
- Project via the dorsal acoustic stria and lateral lemniscus to the contralateral inferior colliculus
Outline the projections of the ventral cochlear nucleus to the inferior colliculi
- Project via the trapezoid body to the superior olivary nucleus to the lateral lemniscus and inferior colliculi
Outline the auditory nerve pathway from the inferior colliculus to the primary auditory cortex
- To the medial geniculate nucleus of the thalamus
- From the medial geniculate nucleus through the auditory radiation to the superior temporal gyrus
Outline two brain regions that auditory nerve fibres project to that respond to loud sound
- Reticular activating system
- Vermis of the cerebellum
Outline how sound frequency is percieved in the auditory cortex and association areas
- Tonotopic maps
- High frequency sounds excite posterior neurons sounds while low frequency sounds excite anterior neurons
- Caused by lateral inhibition
What is the role of the lateral superior olivary nuclei?
- Concerned with direction sound is coming from
- By comparing the intensities of the sound reaching the two ears
What is the role of the medial superior olivary nuclei?
- Concerned with direction sound is coming from
- By comparing the time lag between the sounds entering the two ears
What are centrifugal fibres?
- Retrograde inhibitory pathways
- From the cortex to the cochlea
- Which allow attention of particular sound qualities and rejection of others
Where is Wernicke’s area located?
- Superior temporal gyrus
- Posterior to the primary auditory cortex
What is the role of Wernicke’s area in speech?
- Sensory: Interpretation of language
- Motor: Determination of choice of words to be spoken
Where is Broca’s area located?
- Prefrontal cortex
What is the role of Broca’s area in speech?
- Motor patterns for control of the larynx, lips, mouth and respiratory system that form words
What is auditory receptive aphasia?
- Inability to understnad the spoken word
What is visual receptive aphasia?
- Inability to understand the written word