Pathways Flashcards
Herpes pathway (4)
1) Infectious saliva carries HSV-1 into nerve terminal at broken skin
2) Retrograde transport back to soma
3) Replication in soma
4) Recurrence with anterograde transport causes blisters on lips at times of stress
Rabies Pathway (5)
1) Virus enters nerve terminal via bite and saliva
2) Retrograde transport to soma
3) Replication occurs in soma
4) Cell death
5) virus spreads
no anterograde transport
Alzheimers Pathway (4)
1) Beta amyloids accumulates outside neurons - form amyloid plaques
2) Plaques phosphorylate Tau
Tau changes confirmation
Change in conformation causes neurofibrillary tangles
3) Microtubules disassemble
4) Distorted Tau infects other nearby neurons
Thumbtack to AP sequence (4)
1) thumbtack enters skin
2) membrane of nerve fibers in skin is stretched
3) Na+ permeable channels open
4) surface membrane is depolarized
Neurotransmitter release pathway/acronym (4)
1) NT is synthesized and packaged
2) NT is released from pre-synaptic cells
3) NT produces an action or effect on post synaptic cell
4) Termination of the signal/removal
SRAT
amino acid pathways?
GABA
1) Glutamate + GAD -> GABA
Glycine & Glutamate
1) form from glucose
amine pathway - monoamine seratonin
T 5H S5
T 4-HTP
amine pathway - monoamine acetylcholine
A A
ChAT
amine pathway - catecholine
What is the peptide sequence?
1) mRNA goes into cytosol & is acted on by rough ER
2) In rough ER – peptide protein string is formed (Precursor peptide)
3) In golgi apparatus – enzymes break the precursor peptide into smaller active neurotransmitter molecules
4) The neurotransmitter molecules form a membrane bud off of the ER
5) Via axoplasmic flow – travel to terminal button
6) Goes into the synaptic vescicles
Calcium release pathway?
1) AP depolarizes terminal membrane
2) Voltage gated Ca channels open
3) Ca enters and binds to synaptotagmin
4) Synaptotagmin triggers the SNARE complex to change conformation, allowing for vesicle fusion and release of NT
ligand gated channel pathway?
general Gprotein pathway
1) Neurotransmitter binds to receptor
2) Receptors gains affinity for Gprotein complex
3) ON REACTION - GTP/GDP exchange on alpha subunit
4) Alpha subunit separates
5) Each subunit activates their associated effector proteins
6) OFF REACTION - GTP/GDP
7) Off reaction triggers the alpha subunit to no longer be able to activate the effector protein
8) the subunits combine again and the signaling is turned off
9) the cycle continues to run as long as there is a neurotransmitter present in the cleft
Gprotein method 1 pathway? - muscarninc
when K+ channel = open
- when beta gamma subunit is released
when K+ channel = closed
- ground state
Grpotein method 1 pathway? - enzymes
1) Neurotransmitter binds with receptor
2) GTP/GDP exchange occurs
4) Activation of downstream enzyme
Gprotein method 2 - camp pathway 1? CREB
Gprotein method 2 - camp pathway 2? AC suppression
Gprotein method 2 - camp pathway 3? K channel
G protein method 2 - IP/DAG pathway?
brain development pathway
