Patent Ductus Arteriousus Flashcards
List congenital symptoms associated with PDA
Increased risk of ventiliation
pulmonary hemorrhage
Bronchopulmonary dysplasia
diastolic steal could be associated with renal hypoperfusion intestinal ischemia necrotizing enercolotis (NEC) intraventricular hemorrhage
What is medical treatment of PDA
In premature neonates in can be prophylactic or symptomatic
COX inhibitor within first 24 hours. Indomethacin and ibuprofen are equally effective at producing closure. Closure rates are 60 to 80% with a single dose.
Ineffective in term neonates because of lack of prostaglandin responsive contractile smooth muscle in their ductal tissue.
Surgical therapy in premature infants
reserved for failed medical therapy in symptomatic patients and for those with contraindications for COX inhibitor therapy. (NEC/renal dysnfunction/IVH)
Surgery for Full-Term infants, children, and Adult
Surgical or transcatheter closure is the mainstay of therapy.
Indicated for both symptomatic and asymptomatic patients to reduce the risk of endocarditis and pulmonary hypertension.
Asymptomatic may undergo elective closure 1 to 2 years of age–to facilitate VATS
Can be done via thoracotomy, median sternotomy, device, or VATS
Complications of a PDA ligation
Mortality < 1% left recurrent laryngeal nerve injury bleeding postoperative chylothorax development of coarctation
What is surgical approach for PDA
Posteriolateral thoractomy (3rd or 4th intercostal space)
Device closure
Video-assisted thoracoscopic
*(not for adulats)
Remember to put an adult on CPB
place a fogarty cath in the PDA and close it from the inside
snare both PA
you could place a vent into the PA and drain…and then repair from the inside or outside
What is prevalence, pathophyioslogy and natural history.
20 to 80% of neonates and varies inversely with gestational age and birth weight
Genetic implications of prostaglandin receptors and regulators of smooth muscle contraction
In utero-DA shunts-right to left because of high resistance of pulmonary circulation. Birth–decline in PVR–ductal closure in a few hours–mediated by loss of placental source of prostaglandins, increased arterial oxygen tension.
PDA of term infant unlikely to respond to NSAID but pre-term will.
Spontaneous closure 4 days (90 to 95%) and 80 to 90% of premature infants at 30 to 37 weeks