Mitral Valve studies Flashcards
25 years of Gore-Tex Mitral Valve Repair
Tirone David
JTCS 2012
“Chordal replacement with PTFE for mitral valve repair: 25 year experience”
1986- to 2004—606 patients
Isolated Anterior 17.6%, isolated posterior 29.5%, bileaflet prolapse 52.9%
Mean follow up 10.1 years
18 years freedom from re-operation was 90.2%
Freedom from severe MR was 67.5%
Mitral Valve Surgical Procedures in the Elderly
Annals of Thoracic Surgery: 94; 5; Dec 2012: 2004
This is a strong study from Lepzig about Mitral valve surgery in patients at age 70 years and older.
2500 patients over a 10 year period. 97% had MR,
65% were mitral valve repair and rest were replacement. CABG was identified as associated with inferior short and long-term survival.
30 day mortality was 3.1% and 5 year 55.2%.
Relevant study because some centers report much higher rates of operative mortality (25% for MV). This study has good long term outcomes as well.
Mitral Valve disease: if the mitral valve is not reparable/failed repair is a bioprosthesis suiting for replacement
Jamieson WE, Vancouver groupt
Eur J Cardiothorac Surg 2009 Jan25;(1)
Examined the mitral porcine bioprosthessis (CE SAV)
1135 patients from 2982 to 2000
Examined structural valve deterioration and freedom from composites of complications
For 51-60
actual freedom from SVD @ 18 year was 56.0%
actuarial freedom SVD @ 18 years was 14.7%
for 61-70
actual freedom from SVD @ 18 year was 69.2%
actuarial freedom from SVD @ 18 year was 26.5%
For > 70
actual freedom from SVD @ 15 years was 92
actuarial freedom from SVD @ 69 %
The overall actual freedom at 15 to 18 years for > 70 age grouo was for for valve-related reoperation 94 % and valve related mortality was 87%
ISTIMIR: The Italian Study on the treatment of Ischemic Mitral Regurgitation
1006 patients with ischemic MR and impaired LV ventricular function (EF < 40%) at 13 italian centers between 1996 and 2011
29% underwent mitral valve replacement and 70.4% underwent mitral valve repair. Propensity scores and 244 pairs of patients were mattached
median f/u 46.5
Early death was 3.3% for repair and 5.3% for replacement
8 year survival was 81.6% and 79.6% for repair and replacement
Freedom from all-cause reoperation was 64% vs 80%
No improvement in LV function
suggest that mitral valve replacement is suitable for chronic IMR
What are rates of post operative MR following restrictive annuloplasty
Moderate/severe MR has been shown to be as much as 33% in pts at months and more then 70% at 5 years.
predicting who is likely to benefit from replacement or repair is tough…Some say LVEDD of > 65mm should be replaced.
Predictors of mitral regurgitation recurrence in pts with heart failure undergoing mitral valve annuloplasty
Robert Dion and a group…
Am J Cardiol 2010;1065:395-401
This study has good images for echo IMR values
Basal mitral anterior leaflet angle Posterior mitral leaflet angle tenting area tenting height coaptation length mitral annulus Coapatiation-to-septum distance
What outcomes from the Dion Study predicted failure of annuloplasty
Distal mitral anterior leaflet tethering
posterior leaflet tethering
5 year CorCap outcomes: Beneficial effects of CorCap cardiac support device: Five year results from Acorn Trial
107 patients—no mitral valve repair/replacement and half in each group
treatment group had signficant reductions in left ventricular end-diastolic volume as well as small increase in sphericiity index.
More patients in treatment group had improve in NHYA 1 functional class
There was no differnence in freedom from composite end point of death major cardiac procedures
What is CorCap
Passive polymer cardiac support device
a significant increase in ejection fraction and decrease of LV end-diastolic volume were observed
Adjustable Annuloplasty ring (Micardia)
The enCorSQ is an adjustable ring (leaves a wire attached to the sub that can be heated and further reduce annuloplasty)
What is EVEREST study II details
N = 279 pts (2:1 radndomization)
184 to mitra clip and 95 mitral repair
Primary composite endpoint—freedom from death, surgery for mitral dysfunction, and freedom from MR > 3+ at 12 months
Primary safety endpoint—included transfusion of >2U of Blood
What were results of EVEREST II
mitral clip 55%
Surgery 73%
safety event was 15% with mitral clip and 48% with surgery. This was because of the blood transfusion data.
EVERST-II
April 2011 NEJM
Randomized comparison of percutaneous repair with conventional surgery for mitral regurgitation to evaluate the efficacy and safety of the percutaneous approach.
Findings: No difference between two groups in terms of mortality and morbidity for major adverse cardiac events; only difference is need for transfusion (8.8% vs 53.2%)
At 30 days
E-clip: 6% mortality, 20 % converted to mitral valve surgery; 21% with grade 3+ or 4+ MR
Surgery: 6% mortality, recurrence of 3 - 4+ MR was also 20% (poor outcome)
The conclusion that E-Clip offers “superior safety”…crazy
Mitral valve repair vs Mitral Valve Replacement
Enriquuez-Sarano et al., (Group from Mayo Clinic)
“Valve Repair Improves the Outcome of Surgery for Mitral Regurgitation”
1995- Circulation
195 pts with valve repair and 214 with replacement for organic MR.
Overall survival at 10 years was 68% with repair compared to 52% with replacement
Operative mortality 2.6% with repair vs 10% with replacement
Ejection fraction was lower with both groups but better with repair.